Brain radiation with or without gadolinium nanoparticles for brain metastases
Part of Brain & nervous system, Cancer, Digestive system, Lungs & breathing, Skin clinical trials.
This trial tests whether adding tiny gadolinium-containing nanoparticles to standard brain radiation can better control brain metastases from certain cancers. It is for people with tumors that have grown after immunotherapy, are from certain cancers (like melanoma, GI, or HER2+ breast), are cystic, are large, or have come back after prior radiation.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You have a solid tumor that has spread to the brain, with at least one tumor 5mm or larger.
- Your cancer is melanoma that grew despite immunotherapy, or comes from the GI tract, or is HER2-positive breast cancer, or your brain tumors are cystic or at least 2cm, or they came back after prior brain radiation.
- You are 18 or older.
- Your kidney function is good enough (eGFR at least 60).
- You are able to care for yourself but not do active work (Karnofsky score 70 or higher).
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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