Clinical trials
Colorectal cancer clinical trials
Cancer of the colon or rectum, often beginning as small growths called polyps. We’re tracking 1,068 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06614647Recruiting
Digital follow-up for colorectal cancer survivors
This trial tests a smartphone-based follow-up program for people who have been treated for early-stage colorectal cancer. The goal is to see if a digital, need-based care guide can replace standard follow-up visits.
Herning, Central JutlandAges 18 years+ - NCT05501379Recruiting
Track activity in cancer patients during treatment
This study compares how physical activity answers on a questionnaire match what a motion tracker measures. It may help researchers understand activity levels in people with lymphoma, colorectal, or pancreatic cancer during treatment.
GreifswaldAges 18 years+ - NCT07808164Recruiting
Protein markers in solid tumors: a Vietnamese tissue study
This study looks at tissue samples from Vietnamese patients with solid tumors to understand the presence of certain proteins (ENPP1, cGAS, and FAP). The goal is to learn more about these tumors, which might help develop better treatments in the future.
Hanoi, HanoiAges 18 years+ - NCT06185556RecruitingPhase 2/Phase 3
New treatments for liver tumors near blood vessels or bile ducts
This trial tests two procedures—irreversible electroporation and stereotactic body radiotherapy—for people whose colorectal cancer has spread to the liver (1–3 tumors near major blood vessels or bile ducts) and can't be surgically removed or treated with heat. The goal is to see if these approaches can safely destroy those hard-to-reach tumors.
Amsterdam, North HollandAges 18 years+ - NCT06279351RecruitingPhase 2
Thalidomide plus standard chemo and cetuximab for left-sided colon cancer
This trial tests whether adding the drug thalidomide to standard chemotherapy plus cetuximab can work better for people with advanced left-sided colorectal cancer that hasn't been treated before. If you have a specific gene type (RAS/BRAF wild-type) and are in generally good health, this study may be an option.
Chongqing, Chongqing MunicipalityAges 18–75 - NCT05434026Recruiting
Colorectal cancer database study for people having surgery
This study enrolls people with colon cancer found on biopsy and who are able to have surgery. It mainly builds a medical database to help researchers understand care and outcomes, and it depends on you consenting to participate.
BeijingAges Any age - NCT07702292RecruitingPhase 2
68Ga-BED003 PET scan for certain cancers
This trial tests a new PET imaging agent that targets a protein called FAP, which appears in many solid tumors. The goal is to see if this scan can better find and measure cancer in the body.
Bergamo, LombardyAges 18–79 - NCT07432633RecruitingPhase 1/Phase 2
Imaging scan to detect cancer-linked protein in several tumor types
This trial tests a new PET scan tracer that targets a protein found on certain cancer cells. It may help doctors better see and understand tumors in people with colorectal, gastric, pancreatic, lobular breast, or ovarian cancer.
Dallas, TexasAges 18–80 - NCT06484153RecruitingPhase 2
New drug combo for advanced colorectal cancer
This trial tests a new combination of three drugs—fruquintinib (a targeted therapy), pirfenidone (an anti-fibrotic drug), and an immunotherapy (anti-PD-1)—for people with advanced colorectal cancer that has not responded to at least two prior treatments. The goal is to see if this triple therapy can shrink tumors more effectively than current options.
Wuhan, HubeiAges 18–75 - NCT06997458Enrolling by invitation
Liquid biopsy study for advanced lung or colon cancer
This study is testing a simple blood draw (liquid biopsy) to track advanced lung or colon cancer. It may help doctors understand the cancer better without needing repeated tissue biopsies.
Granada, AndalusiaAges 18 years+ - NCT07237984Recruiting
COCO study for colorectal cancer screening
This trial looks at substances in your body to help find colorectal cancer earlier. It is for people who are already scheduled for a colonoscopy, either because of a positive stool test or cancer symptoms.
HillerødAges 18 years+ - NCT07307664Recruiting
Increasing genetic testing for cancer patients
This trial aims to increase the use of genetic testing (germline testing) among cancer patients by working with healthcare providers like oncologists and nurses. If you are an oncology care team member treating adults with breast, pancreatic, or colorectal cancer, this study may be for you.
Los Angeles, CaliforniaAges Any age - NCT07543744RecruitingPhase 1
Comparing RPH-030 to Vectibix for metastatic colorectal cancer
This trial tests whether a new drug called RPH-030 works similarly to an existing drug called Vectibix in treating advanced colorectal cancer that has spread. Both drugs will be given alongside chemotherapy (FOLFIRI) as a first-line treatment.
ArkhangelskAges 18 years+ - NCT07411599RecruitingPhase 1/Phase 2
CAR-NK cell therapy plus cetuximab for belly-spread colorectal cancer
This trial tests a new cell therapy (CAR-NK cells given directly into your belly and a vein) combined with a targeted drug (cetuximab) for colorectal cancer that has spread mainly to the lining of your belly. It aims to see if this treatment can shrink tumors and help people who have run out of standard chemotherapy options.
Houston, TexasAges 18 years+ - NCT07448142RecruitingPhase 2
Low-dose radiation with immunotherapy and chemo for advanced rectal cancer
This trial tests a combination of low-dose radiation, an immunotherapy drug called pucotenlimab, and chemotherapy for locally advanced rectal cancer that has not spread. The goal is to see if adding radiation helps shrink the tumor more effectively before surgery.
Guangzhou, GuanggongAges 18–75 - NCT07020221RecruitingPhase 1/Phase 2
Study of VS-7375 for cancers with a KRAS G12D mutation
This study tests an experimental drug called VS-7375 for people with advanced solid tumors that have a specific genetic change called KRAS G12D. The goal is to see if the drug can shrink tumors or slow their growth.
Los Angeles, CaliforniaAges 18 years+ - NCT03303833Recruiting
Lynch syndrome study following people over time
This study follows adults with Lynch syndrome (an inherited gene change) using regular questionnaires and tracking health over time. It may help researchers understand how the condition progresses and improve care for people with these gene mutations.
WageningenAges 18–80 - NCT03925662RecruitingPhase 3
Mebendazole added to stage 4 colon cancer care
This trial studies whether adding mebendazole (an existing anti-parasite medicine) to standard treatment can improve outcomes for people with stage 4 colon cancer. You might qualify if you have stage 4 colorectal cancer and none of the key safety concerns.
CairoAges 18 years+ - NCT05236972RecruitingPhase 3
PD-1 antibody after colon cancer surgery for dMMR stage III
This phase 3 trial studies a PD-1 antibody medicine given after surgery to help prevent stage III colon cancer from coming back. It is specifically for people whose tumor is mismatch repair–defective (dMMR) or MSI-H, which may make the cancer more responsive to immune-based treatment.
GuangzhouAges 18–75 - NCT05202314Recruiting
Camrelizumab plus chemo after stent for left bowel cancer
This study tests whether adding camrelizumab (an immune therapy) to chemotherapy—after a stent is placed to open a blocked left-sided colon—improves outcomes. It’s meant for people whose cancer can still be removed with surgery after the blockage is treated.
Beijing, Beijing MunicipalityAges 18–80 - NCT04842006Recruiting
Personalized treatment plan for rectal cancer before and after surgery
This trial looks at a personalized treatment approach for rectal cancer. It aims to guide the best chemotherapy and (if needed) radiotherapy before and after surgery, based on scans and specific test results.
Helsinki, UusimaaAges 18–100 - NCT05848609Recruiting
Quality of life study for older adults having robotic colon surgery
This study looks at how older people feel and function after robotic surgery for colorectal cancer. It may help doctors understand what to expect and how to better support quality of life during recovery.
BrusselsAges 70 years+ - NCT05853094Recruiting
Testing different ways to create a stoma after rectal cancer surgery
This trial looks at how different stoma (opening in the belly) approaches affect recovery after curative rectal cancer surgery. It may help doctors choose the safest, most comfortable option for bowel function and healing after surgery.
ShanghaiAges 18–80 - NCT06204484Recruiting
MRD-guided Chemo Timing for Early Colon Cancer
This trial is for people with early-stage colon cancer (stage II high-risk or stage III low-risk) that is not MSI-H. It uses a blood test (MRD) to see if you can safely delay or skip extra chemotherapy after surgery, based on whether the test finds any leftover cancer cells.
Guangzhou, GuangdongAges 18–70
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Common questions
- Are there clinical trials for colorectal cancer?
- Yes. Clin2 currently lists 1,068 recruiting colorectal cancer studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a colorectal cancer trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a colorectal cancer trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.