Clinical trials
Colorectal (Colon or Rectal) Cancer clinical trials
Below are recruiting colorectal (colon or rectal) cancer clinical trials, each written for real people, not researchers. We’re tracking 900 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT05424692Recruiting
Test tumor drug sensitivity to guide after-surgery colon cancer care
This study looks at whether testing a small tumor sample can identify which medicines are more likely to work for colorectal cancer after surgery. The results are used to help choose the best “after-surgery” treatment plan, when you have not had chemotherapy before surgery.
Beijing, Beijing MunicipalityAges 18–75 - NCT05434026Recruiting
Colorectal cancer database study for people having surgery
This study enrolls people with colon cancer found on biopsy and who are able to have surgery. It mainly builds a medical database to help researchers understand care and outcomes, and it depends on you consenting to participate.
BeijingAges Any age - NCT05806931RecruitingPhase 2
Alternating two pills plus bevacizumab for advanced colon cancer
This Phase 2 study tests a treatment plan that alternates two cancer pills and adds bevacizumab (a blood-vessel drug) for metastatic colon cancer that has come back or worsened after standard treatment. It may help shrink tumors and slow disease growth after later-line therapy options.
Elizabeth, New JerseyAges 18 years+ - NCT06640166RecruitingPhase 2
Encorafenib + Cetuximab with FOLFIRI after progression
This trial tests adding a new chemotherapy regimen (FOLFIRI) to the combination of Encorafenib and Cetuximab for people with a specific type of advanced colorectal cancer that has started growing again after initial treatment with Encorafenib and Cetuximab. The goal is to see if the new combination can help control the cancer longer.
MilanAges 18 years+ - NCT07222800RecruitingPhase 3
Testing a new drug plus chemo for stage 4 colorectal cancer
This study tests a new experimental drug (PF-08634404) combined with standard chemotherapy for people with stage 4 colorectal cancer who have not yet been treated for their advanced disease. The goal is to see if the combination helps shrink or slow the growth of tumors.
Chandler, ArizonaAges 18 years+ - NCT06272461Recruiting
Comparing lidocaine vs. ketamine for colorectal surgery pain
This trial compares two pain-relief medicines (lidocaine vs. ketamine) given through an IV during open colorectal surgery. It aims to find which one works better to reduce pain after surgery.
NabeulAges 18–90 - NCT06972160Recruiting
Boosting colorectal cancer screening in Barcelos/Esposende
This study looks at ways to help more people get screened for colorectal cancer. If you're between 50 and 74 and haven't had certain screenings recently, you may be able to join.
PortoAges 49–75 - NCT06958926Recruiting
Study of colon cancer that returns after surgery
This study looks at colon cancer that comes back in the same area after surgery. It may help doctors understand how to better treat this type of recurrence.
HsinchuAges 18 years+ - NCT06540027Enrolling by invitation
Minimally invasive surgery for rectal cancer inflammation
This study looks at how different types of surgery (open, laparoscopic, or robotic) affect inflammation throughout the body in people with rectal cancer. It may help doctors understand which approach is gentler on your immune system.
IstanbulAges Any age - NCT06546176Recruiting
Comparing two surgical methods for colorectal cancer
This trial tests two different ways to reconnect the intestine after removing a sigmoid or upper rectal tumor. The goal is to see which method leads to better healing.
CairoAges 18 years+ - NCT06997497RecruitingPhase 3
Study of Calderasib with other drugs for colorectal cancer
This trial tests a new drug called Calderasib combined with targeted therapy or chemotherapy for people with advanced colorectal cancer that has a specific genetic change (KRAS G12C mutation). It may be an option for those who have not had prior treatment for advanced disease.
Los Angeles, CaliforniaAges 18 years+ - NCT05789433Recruiting
Aerobic exercise study after colon or rectal cancer surgery
This trial studies whether a supervised aerobic exercise program helps muscles “remodel” (change/strengthen) after colon or rectal cancer treatment. It may help people improve physical function during recovery, but you can only join if it’s safe for you and you can follow the study plan.
Orlando, FloridaAges 18 years+ - NCT07154173Recruiting
Gut bacteria study in metastatic colorectal cancer
This study looks at gut bacteria in people with colorectal cancer that has spread (metastatic). It aims to find patterns in the bacteria that may help doctors choose better treatments.
Guangzhou, GuangdongAges 18–75 - NCT07419490Recruiting
Moving ovaries and uterus to preserve fertility during pelvic radiation
This trial moves the ovaries and uterus higher in the belly before pelvic radiation to protect them, so patients may still be able to have children later. It is for women aged 18-40 with pelvic cancers that require radiation.
Tampa, FloridaAges 1.5 years–3.3 years - NCT07573371Recruiting
Understanding bowel changes after rectal cancer surgery
This study helps doctors better understand and treat bowel control problems that can happen after rectal cancer surgery or other rectal treatments. If you've had this surgery or treatment, the study team wants to learn more about your recovery and test new ways to help.
AalborgAges 18 years+ - NCT06565052Recruiting
Exercise and nutrition before rectal cancer surgery study
This trial tests whether a personalized exercise and nutrition program before rectal cancer surgery can help you recover faster and have fewer complications. If you are not very active right now, you may be able to join.
Boston, MassachusettsAges 18 years+ - NCT04624555Recruiting
Check how well stool DNA tests help watch for colon cancer return
This trial studies whether an at-home stool DNA test (Mt-sDNA) can safely and usefully monitor people after colon or rectal cancer treatment. It’s mainly about whether the test is practical and helpful during routine follow-up.
Cleveland, OhioAges 18 years+ - NCT04668872Recruiting
Biopsy after liver radiation to see tumor cell changes
This trial gives radiation to liver tumors and then takes a small tissue sample (biopsy) to look for changes in the cancer cells after treatment. The goal is to learn what the radiation is doing inside the tumor, which may help improve future treatments.
New York, New YorkAges 18 years+ - NCT06703632Recruiting
Testing a new stool test for early colon cancer detection
This study is evaluating PreveCol, a new second-line stool test for people aged 50–69 who had a positive FIT/FOBT result and are already scheduled for a colonoscopy. It aims to find out if this test can help detect colorectal cancer earlier.
Lisbon, Lisbon DistrictAges 50–69 - NCT07764497RecruitingPhase 2
Chemotherapy through liver artery for colorectal cancer that spread to liver
This trial tests giving chemotherapy directly into the liver artery for people whose colorectal cancer has spread only to the liver and cannot be surgically removed. The goal is to shrink the tumors and make the liver healthy enough for surgery.
Toronto, OntarioAges 18 years+ - NCT06864338Recruiting
Pilot study for a new colorectal cancer screening test
This study tests a new stool-based test for detecting colorectal cancer and advanced polyps. It aims to see how well it works compared to a colonoscopy. The results may lead to a simpler screening option.
Morrisville, North CarolinaAges 18 years+ - NCT06202183Recruiting
Home exercise for gut health in young colorectal cancer patients
This study tests whether a home-based exercise program can improve the health of your gut bacteria during chemotherapy for young-onset colorectal cancer. It aims to help you feel better and potentially improve how well your treatment works.
Boston, MassachusettsAges 18–50 - NCT06385418RecruitingPhase 2
Colon chemotherapy for colorectal cancer
This trial tests putting a chemo drug (fluorouracil) directly into the colon through a tube. It's for people with colorectal cancer who are already getting other cancer treatment, to see if adding local chemo helps shrink the main tumor.
Nanjing, JiangsuAges 18–75 - NCT06200831Recruiting
Same surgery or two surgeries for colorectal cancer with liver spread
This trial compares having one surgery to remove both the colon tumor and liver tumors at the same time versus having two separate surgeries. It aims to find which approach is safer and works better for patients whose cancer has spread only to the liver.
OsloAges 18–80
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Common questions
- Are there clinical trials for colorectal (colon or rectal) cancer?
- Yes. Clin2 currently lists 900 recruiting colorectal (colon or rectal) cancer studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a colorectal (colon or rectal) cancer trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a colorectal (colon or rectal) cancer trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.