Clinical trials
Colorectal clinical trials
Below are recruiting colorectal clinical trials, each written for real people, not researchers. We’re tracking 1,202 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07291180Recruiting
Personalized heated chemo for advanced appendix or colon cancer
This study tests a personalized way to deliver heated chemotherapy directly into the belly during surgery for advanced appendix or colorectal cancer that has spread to the lining of the abdomen. The goal is to see if tailoring the chemo drugs to your tumor can improve outcomes.
New Haven, ConnecticutAges 18–81 - NCT06881537RecruitingPhase 2
Chemo and targeted therapy before surgery for recurrent colorectal cancer
This trial tests a combination of chemotherapy (CapeOX), a targeted drug (bevacizumab), and an immunotherapy (anti-PD1) given before surgery for colorectal cancer that has come back locally (in the same area). The goal is to shrink the tumor and improve surgical outcomes.
ShanghaiAges 18–75 - NCT07284849RecruitingPhase 3
Testing a new drug combo for advanced colorectal cancer
This trial tests whether adding an experimental drug (INCA33890) to standard chemotherapy and bevacizumab helps people with a certain type of advanced colorectal cancer. It is for those whose cancer has spread and has not been treated yet with systemic therapy.
Mobile, AlabamaAges 18 years+ - NCT07283575Recruiting
Blood test to monitor metastatic colorectal cancer treatment (PROMET)
This study is testing whether a blood test that looks for tiny bits of tumor DNA (ctDNA methylation) can help monitor how well treatment is working in people with colorectal cancer that has spread. If you are getting radiation and chemotherapy (with or without an immunotherapy drug), this trial may help your doctor see if the treatment is working sooner.
ShanghaiAges 18–75 - NCT07280143Recruiting
MASLD risk in breast or colorectal cancer survivors
This study looks at whether breast or colorectal cancer survivors are more likely to develop a liver condition called MASLD (fatty liver disease not caused by alcohol). It uses blood tests, imaging, and possibly an MRI to check liver health.
BernAges 18 years+ - NCT07280949Recruiting
Pain relief study for laparoscopic colon surgery
This study tests a new combination of pain blocks for people having laparoscopic (keyhole) colon or rectal surgery. The goal is to see if adding a back muscle block to the standard abdominal wall block provides better pain relief.
Cairo, GovernorateAges 18–90 - NCT05044689Recruiting
Study to find risk factors for breast and colon cancer
This study is trying to understand what factors might raise the risk of breast cancer and colon (large bowel) cancer. You may be enrolled either if you have a confirmed cancer diagnosis (cases) or if you do not have cancer (controls).
Ile-Ife, Osun StateAges Any age - NCT07276529Recruiting
Magnet procedure safety trial for colon surgery patients
This trial tests a new magnet device to connect sections of the colon after surgery. It may be an option for people who need part of their colon removed and are otherwise in good health.
Orlando, FloridaAges 22 years+ - NCT07272928Recruiting
Comparing surgery order for liver spread from colon cancer
This trial looks at whether removing the colon tumor or the liver tumors first affects recovery in patients having both removed at the same time. It helps doctors decide the best surgical approach.
Alessandria, PiedmontAges 18 years+ - NCT07263178Recruiting
Second-line chemo for advanced colorectal cancer
This study looks at different chemotherapy options for people with metastatic colorectal cancer that has stopped responding to first treatment. It aims to find which second-line approach works best.
SeoulAges 19 years+ - NCT04008407Recruiting
Monitoring outcomes after removing certain colon growths
This study follows patients who are having surgery to remove a specific type of flat colon growth. It aims to see how safe and effective a “selective” approach is, based on what the growth looks like and your situation.
Westmead, New South WalesAges 18 years+ - NCT05299840Recruiting
Test a device to choose the first chemo for metastatic colon cancer
This study tests whether using the Oncogramme® device to guide the first-line treatment improves care for people with metastatic colorectal (colon/rectum) cancer. If the device helps pick the most suitable standard chemotherapy plan, it could lead to better outcomes than choosing without it.
MarseilleAges 18 years+ - NCT07264556Recruiting
Comparing three anesthesia types for colorectal cancer surgery
This trial compares three types of anesthesia during colorectal cancer surgery to see how they affect the body's immune response and cancer cells. It may help find the safest and most effective anesthesia option for people having this operation for the first time.
Shanghai, Shanghai MunicipalityAges 18–80 - NCT07262840Recruiting
Health behavior change for people at high risk for colorectal cancer
This trial tests a program to help people at high risk for colorectal cancer change their health behaviors to lower their risk. It might help you if you are worried about your risk and want to make positive changes.
Shenyang, LiaoningAges 1.5 years–6.7 years - NCT06888843RecruitingPhase 2
Chemotherapy for colorectal cancer in patients 70+
This trial tests two chemotherapy drugs, capecitabine alone or with oxaliplatin, in people aged 70 or older after surgery for stage III colorectal cancer. The goal is to find out which treatment works better to prevent cancer from coming back.
Nizhny NovgorodAges 70–90 - NCT07257653RecruitingPhase 2
Cetuximab beta plus fruquintinib with or without immunotherapy for first-line advanced colorectal cancer
This trial tests a combination of two targeted drugs (cetuximab beta and fruquintinib) with or without an immunotherapy drug for people with a specific type of advanced colorectal cancer that has not been treated before. It aims to see if this approach is safe and effective for those whose tumors have certain genetic markers (RAS and BRAF wild type).
Hangzhou, ZhejiangAges 10–85 - NCT07254910Recruiting
Study to boost colon cancer screening in American Indians
This study tests a new program to help American Indian adults get screened for colorectal cancer. If you qualify, you may get support and reminders to complete a simple stool test at home.
Oklahoma City, OklahomaAges 45–75 - NCT06903325Recruiting
Monitoring DNA markers in blood to predict colorectal cancer return after surgery
This study tests if a simple blood test can detect early signs of colorectal cancer coming back after surgery to remove cancer spread in the abdomen. It may help patients avoid unnecessary treatments and catch recurrence sooner.
Shanghai, Shanghai MunicipalityAges 18 years+ - NCT07249333Recruiting
Complications after pre-surgery radiation for colorectal cancer
This trial looks at side effects and recovery (complications) after chemotherapy or radiation given before surgery for colorectal cancer. It includes people who are somewhat frail (scores 2–4), to see how they do after the operation.
Kamenitz, VojvodinaAges 18 years+ - NCT07247396RecruitingPhase 1
CEA CAR-T therapy after surgery for colorectal cancer spread
This trial tests a special immune cell therapy (CAR-T) that targets a protein called CEA on cancer cells. It is for people with colorectal cancer that has spread to the lining of the belly (peritoneum) and who have already had surgery to remove as much of the spread as possible.
Hangzhou, ZhejiangAges 18–75 - NCT07235293RecruitingPhase 2
Testing a new drug combo for advanced colorectal cancer
This trial tests a new combination of two drugs (DSP107 and atezolizumab) compared to another drug (fruquintinib) for people with advanced colorectal cancer that hasn't responded to standard treatments. The goal is to find a more effective treatment option.
Aurora, ColoradoAges 18 years+ - NCT07230795Enrolling by invitation
AI-guided colorectal cancer screening for adults 45-49
This trial tests whether a computer program can help more adults ages 45-49 get screened for colorectal cancer. If you are due for screening and see a Penn Medicine doctor, you may be able to join.
Philadelphia, PennsylvaniaAges 45–49 - NCT07239063Recruiting
Lung and colorectal cancer tissue test study
This study checks a new way to prepare large tissue samples from lung or colorectal cancer for faster testing. It may help improve how tumors are analyzed.
Guangzhou, GuangdongAges Any age - NCT06649123Recruiting
Rectal mucus test for colorectal cancer diagnosis
This trial is testing a new way to check for colorectal cancer by looking at a sample of rectal mucus. It's for people who have been referred for urgent cancer evaluation and may help find cancer earlier.
Telford, ShropshireAges 18–99
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Common questions
- Are there clinical trials for colorectal?
- Yes. Clin2 currently lists 1,202 recruiting colorectal studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a colorectal trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a colorectal trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.