Clinical trials
Colorectal clinical trials
Below are recruiting colorectal clinical trials, each written for real people, not researchers. We’re tracking 1,227 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06982885Recruiting
AI-assisted imaging study for colorectal lesions
This study tests whether artificial intelligence can help doctors see colorectal lesions more clearly using special advanced imaging. If you have a colorectal lesion, this trial may help improve diagnosis.
Changchun, JilinAges Any age - NCT07283367RecruitingPhase 1/Phase 2
New drug combo for advanced colorectal cancer
This trial tests a new combination of targeted therapies for people with advanced colorectal cancer that has a certain genetic pattern (non-MSI-H, no BRAF V600E mutation). It aims to see if the combination can shrink tumors or slow the cancer's growth.
GuangzhouAges 18 years+ - NCT06015607Recruiting
Testing a new tool for colon polyp removal
This trial tests a new device to help doctors remove larger, non-cancerous polyps from the colon during a colonoscopy. It may make the procedure easier and more effective for eligible patients.
Cleveland, OhioAges 21 years+ - NCT03862781Recruiting
Quicker bowel recovery after minimally invasive right colon surgery
This study looks at whether a specific internal stitch connection (an anastomosis) helps your bowel start working sooner and may help you leave the hospital earlier after right colon surgery. It’s mainly for adults having planned, minimally invasive right hemicolectomy.
Grand Rapids, MichiganAges 18 years+ - NCT06555133RecruitingPhase 2
Study of Y-90, capecitabine, and atezolizumab for advanced colorectal cancer
This trial tests a combination of targeted radiation (Y-90), chemotherapy (capecitabine), and immunotherapy (atezolizumab) for people with colorectal cancer that has spread mainly to the liver and is no longer responding to at least two prior treatments. The goal is to see if this combination can shrink tumors or slow the disease.
Providence, Rhode IslandAges 18 years+ - NCT07401264Recruiting
Colorectal Polyp Image Collection Study
This trial collects video and images of colorectal polyps during a standard colonoscopy. It helps doctors learn more about polyps 10 mm or larger, which may be more likely to be cancerous.
LeuvenAges 18 years+ - NCT06656312Recruiting
EndoAim AI for colon polyp detection
This study tests an artificial intelligence (AI) system called EndoAim that helps doctors find polyps during a colonoscopy. It is for people having a routine colonoscopy with an Olympus endoscope.
Taichung, North Dist.Ages 20 years+ - NCT06757192Recruiting
Colorectal cancer screening study for adults 45-54
This study is looking for people aged 45 to 54 who have not been screened for colorectal cancer (CRC) yet. It aims to understand and improve screening rates. You may be eligible if you are a patient at the health center and have no personal or family history of colorectal cancer.
Boston, MassachusettsAges 45–54 - NCT06717880RecruitingPhase 1
Combination therapy for advanced colorectal cancer
This trial tests a new drug (IBI363) combined with either bevacizumab or furuitinib for people with advanced colorectal cancer that has worsened after standard treatments. It aims to find a more effective option for those who have limited alternatives.
Wuhan, HubeiAges 18–75 - NCT05727163RecruitingPhase 2
Liver-directed chemotherapy versus standard chemotherapy for RAS-mutated CRC
This Phase 2 study tests whether delivering chemotherapy directly into the liver (with an IV medicine added, depending on the group) works better than standard chemotherapy given through a vein. It is for people whose colorectal cancer has spread to the liver but can’t be removed by surgery yet.
Guangzhou, GuangdongAges 18–75 - NCT05967143Recruiting
Registry study for first-time SIR-Spheres in liver tumors
This is an observational (real-world) study that follows people with certain unresectable liver tumors who are getting SIR-Spheres for the first time. It helps doctors understand how this treatment is used in routine care and what outcomes patients experience.
Clichy, CedexAges 18 years+ - NCT06477991Recruiting
No surgery after immunotherapy for MSI-H colorectal cancer
This trial is studying whether some people with a specific type of advanced colorectal cancer (MSI-H/dMMR) might be able to skip surgery after immunotherapy. Doctors will use a blood test (MRD monitoring) to track the cancer, and then decide whether to keep an eye on it or operate.
Kunming, YunnanAges 18–75 - NCT06197425RecruitingPhase 3
Extra chemotherapy after surgery for colorectal cancer with positive ctDNA
This trial tests whether giving more chemotherapy can help people who still have cancer DNA in their blood after surgery and standard chemotherapy for colorectal cancer. The goal is to prevent the cancer from coming back.
DijonAges 18–80 - NCT07007598Recruiting
Preventing bleeding after polyp removal with clips
This trial tests whether placing small clips at the site of polyp removal in the colon can reduce bleeding in patients who take blood thinners afterwards.
Schwerin, Mecklenburg-VorpommernAges 18 years+ - NCT07012954RecruitingPhase 1/Phase 2
ctDNA-guided treatment for RAS/BRAF wild-type colorectal cancer
This trial tests a combination of two drugs—cetuximab or bevacizumab plus a chemotherapy pill (trifluridine/tipiracil)—for people with metastatic colorectal cancer that has no RAS or BRAF mutations. It's for patients whose cancer grew after first responding to cetuximab, and who have had other treatments since then.
Guangzhou, GuangdongAges 18–75 - NCT04359069Recruiting
Shorter urinary catheter time after pelvic surgery
This study looks at whether the urinary (Foley) catheter can stay in place for a shorter time after certain pelvic operations. It aims to see if timing of catheter removal is safer and more comfortable, especially for bladder function.
Los Angeles, CaliforniaAges 18 years+ - NCT07723937Recruiting
GelPOINT-assisted removal of colon and rectal polyps
This study tests a new way to remove large or complex colon and rectal polyps using a special port system called GelPOINT Path. If you have polyps that are hard to remove with standard colonoscopy, this approach may help your doctor remove them safely.
Houston, TexasAges 18 years+ - NCT06642844RecruitingPhase 3
Bevacizumab dose adjustment for colorectal cancer
This trial tests whether adjusting the dose of bevacizumab based on your blood levels can improve first-line treatment for metastatic colorectal cancer that can't be removed with surgery.
BesançonAges 18–99 - NCT07448129Recruiting
Testing SUBMO for removing large colon growths
This trial tests a new liquid called SUBMO that doctors inject under large growths in the colon to make them easier to remove during a colonoscopy. It may help people who need a colon polyp or other lesion removed.
Barcelona, BarcelonaAges 18 years+ - NCT07412613RecruitingPhase 3
Immunotherapy Before and After Surgery for MSI-H Colon Cancer
This trial tests a new immunotherapy drug (AK104) given before and after surgery for a specific type of colon cancer that is MSI-H or dMMR. The goal is to see if the drug helps shrink the tumor and prevent the cancer from coming back.
GuangzhouAges 18–75 - NCT07026786Recruiting
Mindfulness for recovery after colorectal surgery
This study tests whether adding mindfulness sessions to your standard recovery plan helps you heal better after bowel surgery. You'll use a phone or tablet app to guide your mindfulness practice during your hospital stay.
Cleveland, OhioAges 18 years+ - NCT05176483RecruitingPhase 1
New drug combinations for advanced solid tumors
This trial tests a new drug called zanzalintinib, which may slow or shrink various types of advanced cancer. It is given together with other cancer treatments, and the study is looking at many different cancers including kidney, prostate, bladder, lung, liver, and more.
Phoenix, ArizonaAges 18 years+ - NCT04999761RecruitingPhase 1
Study testing new drug combinations for advanced cancers
This study tests new drug combinations for people with various advanced cancers that have progressed after standard treatment, or in some cases, as a first treatment. It aims to see if these combinations are safe and effective. The study is divided into groups based on cancer type and treatment history, so not everyone will qualify for every group.
AichiAges 18 years+ - NCT07741435Recruiting
Simple blood, urine, and saliva test to find cancer early
This study tests a new way to find cancer by looking at DNA in blood, urine, and saliva. It may help detect cancer earlier and monitor how well treatment works.
Bogotá, Bogota D.C.Ages 18 years+
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Common questions
- Are there clinical trials for colorectal?
- Yes. Clin2 currently lists 1,227 recruiting colorectal studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a colorectal trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a colorectal trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.