Clinical trials · North Carolina
COVID-19 clinical trials in North Carolina
We’re tracking 13 recruiting covid-19 studies with a site in North Carolina — including Phase 3 and Phase 4 studies, each written for real people, not researchers.
Recruiting studies in North Carolina
- NCT03808922RecruitingPhase 3
DAS181 treatment for COVID-19 lung infection in immune-compromised adults
This Phase 3 trial tests DAS181 to treat lower lung (chest) viral infections in people with weakened immune systems, including a COVID-19 subgroup. It may help by targeting certain viruses in the lungs, but joining depends on your oxygen needs, recent diagnosis, and other safety factors.
Durham, North CarolinaAges Any age - NCT05218083Recruiting
Mobile rehab program with interval exercise after COVID-19
This trial tests a coach-supported, phone-based rehabilitation program that includes high-intensity interval-style exercise for people recovering from COVID-19 after a hospital stay. It may help improve breathing, strength, and walking by providing structured exercise at home.
Durham, North CarolinaAges 18 years+ - NCT04357574Enrolling by invitation
Testing a radiation treatment decision system during COVID-19 changes
This trial looks at whether a computer system can help guide high-intensity radiation treatment decisions when care has been disrupted during COVID-19. It may help improve how treatment is planned and adjusted during times when patients’ situations change.
Durham, North CarolinaAges 18 years+ - NCT02735707RecruitingPhase 3
Adaptive trial for severe pneumonia care in intensive care
This study tests ways to improve treatment for adults with severe pneumonia that lands them in the ICU, adjusting the plan as results come in. It may help your care team find better treatments for lung infection and breathing/heart support needs.
Winston-Salem, North CarolinaAges 18 years+ - NCT07013474RecruitingPhase 3
Study of ibuzatrelvir for immunocompromised adults with COVID-19
This trial tests an investigational medicine called ibuzatrelvir for adults with COVID-19 who have a weakened immune system. The study aims to see if it helps them recover and avoid severe illness.
Durham, North CarolinaAges 18 years+ - NCT07730450RecruitingPhase 4
COVID-19 vaccine study for healthy adults aged 18 to 64
This trial tests a COVID-19 vaccine in healthy adults to see how well it works. It may be an option if you are not at higher risk for severe COVID-19 and have not had COVID-19 in the past 6 months.
Durham, North CarolinaAges 18–64 - NCT06679140RecruitingPhase 3
Study of Ibuzatrelvir for COVID-19 in high-risk patients
This trial tests if a new medicine called ibuzatrelvir can help people with COVID-19 who have certain health risks avoid severe illness. It is for patients who cannot or choose not to take another COVID-19 pill called Paxlovid.
Monroe, North CarolinaAges 12 years+ - NCT05261139RecruitingPhase 3
Trial for PF-07321332 for children at risk from COVID-19
This trial studies whether PF-07321332 (with ritonavir) helps children under 18 who have COVID-19 at home but are at high risk of severe illness. It looks at whether starting treatment early can reduce progression to worse disease.
Chapel Hill, North CarolinaAges birth–17 years - NCT06667700RecruitingPhase 3
A study of the antiviral molnupiravir for high-risk people with COVID-19
This study tests an antiviral pill called molnupiravir to see if it can prevent severe COVID-19 in people who are at high risk and cannot take Paxlovid. If you have mild to moderate COVID-19 symptoms and certain health risks, you may be able to join.
Charlotte, North CarolinaAges 18 years+ - NCT07221097Recruiting
Testing a new panel to detect COVID-19 and other coronaviruses
This trial uses leftover nasal swab samples to test a new panel that can detect COVID-19 and other coronaviruses. It helps see if the panel works well for diagnosing these infections.
Winston-Salem, North CarolinaAges Any age - NCT04278404Recruiting
Drug safety study for children already on certain medicines
This study measures how certain medicines move through the body and checks their safety in children. It may help doctors better understand dosing and side effects in kids who are already receiving these treatments, or in some kids who recently tested positive for COVID-19.
Chapel Hill, North CarolinaAges birth–20 years - NCT00571389Recruiting
Collecting blood cells from people with cancer or COVID-19
This study collects blood cells using a special blood-draw procedure called leukapheresis (for some participants) and other samples. It aims to better understand cancer and immune-related cells, which may help researchers design or improve future treatments.
Huntersville, North CarolinaAges 5 years+ - NCT05589376Enrolling by invitation
Healthy people registry study for you and me
This study sets up a registry of healthy people who can answer surveys and assessments. It helps researchers understand health and how people feel over time, even if you’re not being treated for a specific illness.
Greenville, North CarolinaAges 2 years+
COVID-19 trials by city in North Carolina
Where these studies are running in North Carolina
Institutions with a site for the recruiting covid-19 studies listed above.
- Duke University Health System · 2 studies
- Duke Vaccine and Trials Unit · 2 studies
- Monroe Biomedical Research · 2 studies
- University of North Carolina at Chapel Hill · 2 studies
- Atrium Health Wake Forest Baptist Medical Center (Wake Forest Baptist)
- Carolina BioOncology Institute
- Duke Cancer Center
- Duke University
What taking part in a covid-19 study involves
A screening visit first
Before anything else, the study team checks whether you fit — usually a visit with some tests. You can stop at any point, and screening is typically free.
Care at a nearby site
Study visits happen at a clinic or hospital taking part. Many studies cover the cost of the study treatment and related visits, and some reimburse travel.
You stay in control
Taking part is voluntary and you can leave a study at any time, for any reason, without affecting your regular care.
The team decides eligibility
Our fit check is a helpful first read, not a decision. The study team makes the final call after reviewing your health history.
COVID-19 trials in other states
Common questions
- Are there covid-19 clinical trials in North Carolina?
- Yes. We're currently tracking 13 recruiting covid-19 studies with a site in North Carolina, each rewritten in plain language so you can see what it's testing and who it's for.
- How do I find out if I qualify for a covid-19 study in North Carolina?
- Each study lists its eligibility rules — age, diagnosis, prior treatments. On every trial page we explain these in plain language and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Do I have to live in North Carolina to take part?
- Not necessarily. These studies have a site in North Carolina, but eligibility is about your health, not your address — some people travel to take part, and a few studies reimburse travel. The study team can tell you what's required.
- Does it cost anything to join a covid-19 trial?
- Using Clin2 is always free. Many trials cover the study treatment and related visits; some reimburse travel. The study team explains exactly what's covered before you decide.
Not the right time?
New covid-19 studies open in North Carolina regularly. Set up a health profile and we’ll quietly watch for studies that fit you and email you when one opens.
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.