Clinical trials · Massachusetts
COVID-19 clinical trials in Massachusetts
We’re tracking 15 recruiting covid-19 studies with a site in Massachusetts — including Phase 1, Phase 2 and Phase 3 studies, each written for real people, not researchers.
Recruiting studies in Massachusetts
- NCT03808922RecruitingPhase 3
DAS181 treatment for COVID-19 lung infection in immune-compromised adults
This Phase 3 trial tests DAS181 to treat lower lung (chest) viral infections in people with weakened immune systems, including a COVID-19 subgroup. It may help by targeting certain viruses in the lungs, but joining depends on your oxygen needs, recent diagnosis, and other safety factors.
Boston, MassachusettsAges Any age - NCT06045338Recruiting
Mind-body program for long COVID symptoms
This trial tests a mind-body intervention to help people with ongoing long COVID symptoms like pain, fatigue, or brain fog. If you've had COVID-19 and have had symptoms at least 3 days a week for 3 months, this study might help.
Boston, MassachusettsAges 18–65 - NCT05866952Recruiting
Breathing and blood-flow testing in long-COVID symptoms
This trial studies how the lungs’ breathing (airflow) and blood flow may be off in people with long-COVID symptoms like tiredness, shortness of breath, or trouble exercising. It may help researchers understand what’s driving symptoms and what kinds of abnormalities could be targeted.
Boston, MassachusettsAges 18–99 - NCT07013474RecruitingPhase 3
Study of ibuzatrelvir for immunocompromised adults with COVID-19
This trial tests an investigational medicine called ibuzatrelvir for adults with COVID-19 who have a weakened immune system. The study aims to see if it helps them recover and avoid severe illness.
Boston, MassachusettsAges 18 years+ - NCT06168019Recruiting
Flu and COVID-19 study for pregnant women in Nagpur
This study follows pregnant women in Nagpur to understand how influenza and COVID-19 affect them and their babies. Participants will be contacted twice a week for symptom checks and may provide blood samples at key points during pregnancy.
Boston, MassachusettsAges 18–50 - NCT06679140RecruitingPhase 3
Study of Ibuzatrelvir for COVID-19 in high-risk patients
This trial tests if a new medicine called ibuzatrelvir can help people with COVID-19 who have certain health risks avoid severe illness. It is for patients who cannot or choose not to take another COVID-19 pill called Paxlovid.
Boston, MassachusettsAges 12 years+ - NCT05261139RecruitingPhase 3
Trial for PF-07321332 for children at risk from COVID-19
This trial studies whether PF-07321332 (with ritonavir) helps children under 18 who have COVID-19 at home but are at high risk of severe illness. It looks at whether starting treatment early can reduce progression to worse disease.
Worcester, MassachusettsAges birth–17 years - NCT06469788Recruiting
COVID-19 vaccine navigation for rheumatology patients
This study looks at helping Black and Latinx adults with autoimmune rheumatic diseases get the updated COVID-19 vaccine. It offers information and support (like testimonials and navigation help) to see what works best.
Worcester, MassachusettsAges 18 years+ - NCT06631287RecruitingPhase 3
Testing baricitinib for persistent long COVID symptoms
This trial tests whether the anti-inflammatory drug baricitinib can improve persistent long COVID symptoms like brain fog, fatigue, and shortness of breath. You may qualify if you had COVID-19 at least 6 months ago and still have bothersome symptoms that affect your daily life.
Boston, MassachusettsAges 18 years+ - NCT04278404Recruiting
Drug safety study for children already on certain medicines
This study measures how certain medicines move through the body and checks their safety in children. It may help doctors better understand dosing and side effects in kids who are already receiving these treatments, or in some kids who recently tested positive for COVID-19.
Boston, MassachusettsAges birth–20 years - NCT04652115RecruitingPhase 2
Defibrotide for severe COVID-19 in adults
This trial tests defibrotide to see if it improves outcomes in people hospitalized with severe COVID-19. You may be considered if you have confirmed infection, abnormal chest imaging, and meet specific severity and safety requirements.
Boston, MassachusettsAges 18–100 - NCT03830320RecruitingPhase 1
PET scan to look for blood clots in the heart or lungs
This Phase 1 study uses a PET scan to detect blood clots (thrombosis) in specific groups of people. It’s testing how well the scan can find clots and how it should be timed with other heart or illness tests.
Boston, MassachusettsAges 18–85 - NCT07536308RecruitingPhase 1
Nasal COVID-19 booster vaccine safety trial
This trial tests a new nasal spray COVID-19 booster vaccine. It aims to see if the vaccine is safe and produces a strong immune response when given through the nose and inhaled, in people who have already been vaccinated.
Boston, MassachusettsAges 18–64 - NCT05973084Recruiting
COVID spread study in Malawi households and vaccine recipients
This study tracks how COVID-19 spreads and causes illness in real households in Blantyre, Malawi, and compares groups after infection or vaccination. If you qualify, you’ll do follow-up testing and visits for several months.
Boston, MassachusettsAges 5–75 - NCT07651761Enrolling by invitation
Vaccine Talk Training for Primary Care Doctors
This study tests whether special training helps primary care doctors have better conversations with patients about flu and COVID-19 vaccines. You may be eligible if you're a patient who visits a participating clinic during the 2026–2027 vaccine season.
Worcester, MassachusettsAges 18 years+
COVID-19 trials by city in Massachusetts
Where these studies are running in Massachusetts
Institutions with a site for the recruiting covid-19 studies listed above.
- Brigham and Women's Hospital · 7 studies
- University of Massachusetts Chan Medical School · 5 studies
- Massachusetts General Hospital · 2 studies
- Beth Israel Deaconess Medical Center
- Boston Children's Hospital
- Boston Medical Center
- Boston University
- Boston University School of Public Health
What taking part in a covid-19 study involves
A screening visit first
Before anything else, the study team checks whether you fit — usually a visit with some tests. You can stop at any point, and screening is typically free.
Care at a nearby site
Study visits happen at a clinic or hospital taking part. Many studies cover the cost of the study treatment and related visits, and some reimburse travel.
You stay in control
Taking part is voluntary and you can leave a study at any time, for any reason, without affecting your regular care.
The team decides eligibility
Our fit check is a helpful first read, not a decision. The study team makes the final call after reviewing your health history.
COVID-19 trials in other states
Common questions
- Are there covid-19 clinical trials in Massachusetts?
- Yes. We're currently tracking 15 recruiting covid-19 studies with a site in Massachusetts, each rewritten in plain language so you can see what it's testing and who it's for.
- How do I find out if I qualify for a covid-19 study in Massachusetts?
- Each study lists its eligibility rules — age, diagnosis, prior treatments. On every trial page we explain these in plain language and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Do I have to live in Massachusetts to take part?
- Not necessarily. These studies have a site in Massachusetts, but eligibility is about your health, not your address — some people travel to take part, and a few studies reimburse travel. The study team can tell you what's required.
- Does it cost anything to join a covid-19 trial?
- Using Clin2 is always free. Many trials cover the study treatment and related visits; some reimburse travel. The study team explains exactly what's covered before you decide.
Not the right time?
New covid-19 studies open in Massachusetts regularly. Set up a health profile and we’ll quietly watch for studies that fit you and email you when one opens.
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.