Clinical trials · California
COVID-19 clinical trials in California
We’re tracking 32 recruiting covid-19 studies with a site in California — including Early Phase 1, Phase 1, Phase 2, Phase 3 and Phase 4 studies, each written for real people, not researchers.
Recruiting studies in California
- NCT06086379Enrolling by invitation
Cognitive rehab therapy for COVID-related thinking problems in Veterans
This study tests a cognitive rehabilitation therapy designed to help Veterans who have memory and thinking problems after COVID-19. It aims to improve daily mental function and quality of life.
San Diego, CaliforniaAges 18 years+ - NCT03808922RecruitingPhase 3
DAS181 treatment for COVID-19 lung infection in immune-compromised adults
This Phase 3 trial tests DAS181 to treat lower lung (chest) viral infections in people with weakened immune systems, including a COVID-19 subgroup. It may help by targeting certain viruses in the lungs, but joining depends on your oxygen needs, recent diagnosis, and other safety factors.
Duarte, CaliforniaAges Any age - NCT04359836Recruiting
Study of gut bacteria in early COVID-19
This trial studies how gut bacteria (“gut flora”) may affect COVID-19 after a recent infection. If you test positive for COVID-19 soon enough, the study may help researchers understand why some people get better faster or have different symptoms.
Ventura, CaliforniaAges 18 years+ - NCT05553743Recruiting
Study of donated breast milk and how it affects child health
This study looks at breast milk donated for research and how it may relate to infant and child health. If you’re an adult who is breastfeeding and can donate extra milk, you may be able to participate.
San Diego, CaliforniaAges 18 years+ - NCT07123727RecruitingPhase 2
Testing Anktiva for long COVID symptoms
This study tests if the drug Anktiva can help people with long COVID. To join, you must have had at least one confirmed COVID-19 infection and now have lasting symptoms that started or got worse after that infection.
El Segundo, CaliforniaAges 18–70 - NCT07013474RecruitingPhase 3
Study of ibuzatrelvir for immunocompromised adults with COVID-19
This trial tests an investigational medicine called ibuzatrelvir for adults with COVID-19 who have a weakened immune system. The study aims to see if it helps them recover and avoid severe illness.
Canoga Park, CaliforniaAges 18 years+ - NCT04330521Recruiting
Cancer patients share experiences during the COVID-19 outbreak
This study asks adult cancer patients to complete a survey and talk in an interview about how COVID-19 affected their care and daily life. Your answers may help researchers understand what challenges cancer patients faced during the pandemic.
Stanford, CaliforniaAges 18–99 - NCT07076862RecruitingEarly Phase 1
PET scan study for long COVID symptoms
This study uses a special PET scan to look at inflammation in the body of people with long COVID (symptoms lasting 3+ months after infection). The goal is to understand why symptoms persist and find better ways to help.
Sacramento, CaliforniaAges 18 years+ - NCT07730450RecruitingPhase 4
COVID-19 vaccine study for healthy adults aged 18 to 64
This trial tests a COVID-19 vaccine in healthy adults to see how well it works. It may be an option if you are not at higher risk for severe COVID-19 and have not had COVID-19 in the past 6 months.
Walnut Creek, CaliforniaAges 18–64 - NCT06679140RecruitingPhase 3
Study of Ibuzatrelvir for COVID-19 in high-risk patients
This trial tests if a new medicine called ibuzatrelvir can help people with COVID-19 who have certain health risks avoid severe illness. It is for patients who cannot or choose not to take another COVID-19 pill called Paxlovid.
Bakersfield, CaliforniaAges 12 years+ - NCT05261139RecruitingPhase 3
Trial for PF-07321332 for children at risk from COVID-19
This trial studies whether PF-07321332 (with ritonavir) helps children under 18 who have COVID-19 at home but are at high risk of severe illness. It looks at whether starting treatment early can reduce progression to worse disease.
Los Angeles, CaliforniaAges birth–17 years - NCT06667700RecruitingPhase 3
A study of the antiviral molnupiravir for high-risk people with COVID-19
This study tests an antiviral pill called molnupiravir to see if it can prevent severe COVID-19 in people who are at high risk and cannot take Paxlovid. If you have mild to moderate COVID-19 symptoms and certain health risks, you may be able to join.
Castroville, CaliforniaAges 18 years+ - NCT07464314RecruitingPhase 1
Testing a combined flu and COVID-19 mRNA vaccine in older adults
This trial is testing whether a new mRNA vaccine that targets both seasonal flu and COVID-19 is safe and creates a strong immune response. It may offer an easier way to protect against two illnesses with one shot.
Fair Oaks, CaliforniaAges 65–85 - NCT04362150Recruiting
Study of long-term effects after COVID-19 infection
This study follows adults who had COVID-19 to learn how the illness can affect health over the long term. It may help researchers understand lasting symptoms and who is at higher risk, which could improve future care.
San Francisco, CaliforniaAges 18–100 - NCT06142253Recruiting
Water exercise for long COVID brain fog
This study tests whether water-based exercise (like swimming or water aerobics) helps veterans recover from long COVID, especially brain fog and memory problems. If you're a veteran with ongoing thinking issues after COVID-19, this may help you improve your symptoms over 8 months.
Palo Alto, CaliforniaAges 18–89 - NCT07108036RecruitingPhase 2
Testing Anktiva for Long COVID Symptoms
This trial tests a medicine called Anktiva to see if it can help people with Long COVID. It's for adults who had a confirmed COVID-19 infection and now have lasting symptoms like fatigue, brain fog, or trouble breathing.
San Francisco, CaliforniaAges 18–70 - NCT04978571Recruiting
Electrical nerve stimulation for long-lasting concussion symptoms
This study tests whether a device that delivers gentle electrical signals to nerves through the skin can help children and teens with concussion symptoms that have lasted at least 3 months. You may be asked to attend clinic visits for the nerve stimulation setup if you meet the safety and scheduling requirements.
Orange, CaliforniaAges 11–18 - NCT05741112Recruiting
Long COVID wearable study to track symptoms and help daily management
This study uses a wearable device to track symptoms and patterns in people with Long COVID, ME/CFS, and/or POTS. The goal is to see how wearable feedback and tracking tools may help you manage your symptoms.
La Jolla, CaliforniaAges 18 years+ - NCT07074158Enrolling by invitation
Looking for long COVID clues in blood
This study compares the blood of people with ongoing long COVID symptoms to healthy people, to look for differences in immune signals and gut bacteria. It could help find better ways to diagnose or treat long COVID.
Palo Alto, CaliforniaAges 18 years+ - NCT07221097Recruiting
Testing a new panel to detect COVID-19 and other coronaviruses
This trial uses leftover nasal swab samples to test a new panel that can detect COVID-19 and other coronaviruses. It helps see if the panel works well for diagnosing these infections.
Los Angeles, CaliforniaAges Any age - NCT05131594Enrolling by invitation
Study immune response in Long COVID patients
This trial studies how your immune system responds in people with Long COVID after a past COVID-19 infection. It may help researchers understand why symptoms linger and how the body’s response could be targeted.
Pasadena, CaliforniaAges 18 years+ - NCT06631287RecruitingPhase 3
Testing baricitinib for persistent long COVID symptoms
This trial tests whether the anti-inflammatory drug baricitinib can improve persistent long COVID symptoms like brain fog, fatigue, and shortness of breath. You may qualify if you had COVID-19 at least 6 months ago and still have bothersome symptoms that affect your daily life.
Los Angeles, CaliforniaAges 18 years+ - NCT04278404Recruiting
Drug safety study for children already on certain medicines
This study measures how certain medicines move through the body and checks their safety in children. It may help doctors better understand dosing and side effects in kids who are already receiving these treatments, or in some kids who recently tested positive for COVID-19.
Los Angeles, CaliforniaAges birth–20 years - NCT04579588Recruiting
Study flu vaccine immunity in people after COVID-19
This study looks at how well your immune system (your body’s infection-fighting system) responds to a flu vaccine after you’ve had COVID-19. It may help doctors understand why some people have different protection after vaccines.
Palo Alto, CaliforniaAges 9–64
COVID-19 trials by city in California
Where these studies are running in California
Institutions with a site for the recruiting covid-19 studies listed above.
- University of California, Davis Medical Center · 3 studies
- University of California, Los Angeles (UCLA) · 3 studies
- University of California, San Francisco · 3 studies
- Children's Hospital Los Angeles · 2 studies
- FOMAT Medical Research · 2 studies
- Pacific Clinical Studies · 2 studies
- Paradigm Clinical Research · 2 studies
- Stanford University · 2 studies
What taking part in a covid-19 study involves
A screening visit first
Before anything else, the study team checks whether you fit — usually a visit with some tests. You can stop at any point, and screening is typically free.
Care at a nearby site
Study visits happen at a clinic or hospital taking part. Many studies cover the cost of the study treatment and related visits, and some reimburse travel.
You stay in control
Taking part is voluntary and you can leave a study at any time, for any reason, without affecting your regular care.
The team decides eligibility
Our fit check is a helpful first read, not a decision. The study team makes the final call after reviewing your health history.
COVID-19 trials in other states
Common questions
- Are there covid-19 clinical trials in California?
- Yes. We're currently tracking 32 recruiting covid-19 studies with a site in California, each rewritten in plain language so you can see what it's testing and who it's for.
- How do I find out if I qualify for a covid-19 study in California?
- Each study lists its eligibility rules — age, diagnosis, prior treatments. On every trial page we explain these in plain language and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Do I have to live in California to take part?
- Not necessarily. These studies have a site in California, but eligibility is about your health, not your address — some people travel to take part, and a few studies reimburse travel. The study team can tell you what's required.
- Does it cost anything to join a covid-19 trial?
- Using Clin2 is always free. Many trials cover the study treatment and related visits; some reimburse travel. The study team explains exactly what's covered before you decide.
Not the right time?
New covid-19 studies open in California regularly. Set up a health profile and we’ll quietly watch for studies that fit you and email you when one opens.
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.