Clinical trials
Depression and Anxiety Symptom clinical trials
Below are recruiting depression and anxiety symptom clinical trials, each written for real people, not researchers. We’re tracking 181 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT05802004Recruiting
Sound stimulation to improve sleep and emotions in young adults
This study tests whether gentle sound stimulation during sleep can improve sleep and how you think and feel in daily life when you have anxiety or depression symptoms. You’ll also do sleep testing in a lab and complete questionnaires to measure changes.
Pittsburgh, PennsylvaniaAges 18–25 - NCT06722287Recruiting
Phone support for family caregivers in Thailand
This study tests a mobile program to support the mental health of family caregivers in Thailand. You participate from home using your phone.
BangkokAges 18–80 - NCT06864156Recruiting
Molecules and vitamin levels in long COVID with brain fog
This study looks at certain molecules (called microRNAs) and vitamin B12 levels in people who have ongoing brain-related symptoms like depression, anxiety, or fatigue after a COVID-19 infection. It may help understand why some people have long-lasting symptoms and could lead to better treatments.
Mexico City, Mexico CityAges 18–65 - NCT07673380RecruitingPhase 2
Mobile health for opioid recovery and mental health
This study uses a mobile health app to help Black and African American individuals recover from opioid or stimulant use and improve mental health. It aims to see if the app can support treatment and well-being.
St Louis, MissouriAges 18 years+ - NCT07656623Recruiting
Probiotics for IBS with stomach issues and stress
This trial tests whether a special probiotic blend can help people with irritable bowel syndrome (IBS) who also have stomach symptoms like heartburn, bloating, or nausea, and feel anxious, depressed, or stressed. It aims to see if the probiotic improves both gut and mood symptoms.
Hanoi, HanoiAges 18 years+ - NCT07198542Enrolling by invitation
Vagus nerve stimulation for somatic symptom disorder
This trial tests if gentle electrical stimulation on the vagus nerve in the ear or neck can help reduce physical symptoms that are closely linked to stress. It is for adults with somatic symptom disorder who are on stable medications.
Douliu, YunlinAges 18–65 - NCT06651801Recruiting
Group therapy for anxiety or depression
This trial tests whether a virtual group therapy program is a good way to help people in Manitoba with anxiety or depression. If you're looking for support and can join a small online group, this might be a helpful option.
Winnipeg, ManitobaAges 18 years+ - NCT07088939Recruiting
Online skills course for depression and anxiety
This trial tests an online course that teaches skills to manage emotions. It is for people in Ontario with mild depression or anxiety who are not currently in therapy.
Windsor, OntarioAges 18 years+ - NCT05734768Recruiting
Study of anxiety and depression in parents after preterm birth
This study compares how parents feel (anxiety and depression symptoms) after having a baby born preterm versus a full-term baby. It also looks at early “building blocks” of thinking and social development in the child.
ReimsAges 18 years+ - NCT07347158Enrolling by invitation
Health education for ostomy patients
This study teaches people with an ostomy (a surgical opening for waste) about their health to improve their quality of life and reduce anxiety or depression. If you are an adult with a permanent or long-term ostomy and live in the Santiago or Barbanza area, you may be able to join.
Santiago de Compostela, A CoruñaAges 18 years+ - NCT06705153Recruiting
Laughter yoga for irritable bowel syndrome
This study tests whether laughter yoga can help reduce IBS symptoms like belly pain and bloating, and also improve mood, sleep, and overall quality of life. You would join video calls where you practice special laughing exercises (no jokes needed) and then answer questionnaires.
Erzurum, YakutiyeAges 18–90 - NCT05028738Recruiting
Test a brain stimulation program for depression and anxiety
This trial studies whether a patient-friendly, scheduled brain stimulation treatment can help reduce symptoms of depression and anxiety. It also checks whether the treatment plan is practical and safe to use in real outpatient settings.
Vancouver, British ColumbiaAges 18 years+ - NCT06073886RecruitingPhase 2
Better brain stimulation for long-lasting concussion symptoms
This trial tests whether personalized brain stimulation can help people who have ongoing symptoms more than 20 on a standard concussion scale, such as headaches, dizziness, or trouble concentrating, after a mild head injury in the past year.
Westwood, Los Angeles, CaliforniaAges 18–65 - NCT07721753Recruiting
Online exercise and therapy for breast cancer mood
This study tests an online program that combines fun video-game exercises with talk therapy to help breast cancer patients who feel depressed or anxious. It takes place in Malaysia and is for Chinese-speaking adults.
Xinxiang, HenanAges 18 years+ - NCT07590115Enrolling by invitation
Behavioral Patterns and Treatment Success in Substance Use Recovery
This study looks at how behavioral patterns change during residential treatment for substance use disorder. Researchers will track your progress over several weeks to understand what helps people succeed in recovery.
Potrerillos, JaliscoAges 18–60 - NCT06617663Recruiting
Online therapy for teens: is it as good as usual care?
This study compares online therapy (ACT or EMDR) to usual care for teens aged 12–18. It aims to see if online sessions work just as well as in-person treatment.
Alkmaar, North HollandAges 12–18 - NCT07646834Recruiting
Brain-Gut Study of IBS with Anxiety and Depression
This study explores how stress and mood changes affect irritable bowel syndrome (IBS) using brain imaging. Researchers will scan your brain and collect health information to understand the connection between your gut and mental health.
Xi'an, ShaanxiAges 18–60 - NCT07363980Enrolling by invitation
Heart CT Study for Rheumatoid Arthritis Patients
This study uses a special heart CT scan to look for early signs of heart disease in people with rheumatoid arthritis. It may help find problems before symptoms start.
AarhusAges 50–75 - NCT07133893Recruiting
Light therapy for moderate anxiety
This study tests a non-invasive light therapy (tPBM) that shines near-infrared light on the head to help with anxiety. It's for people with moderate anxiety and no major depression.
Austin, TexasAges 18–100 - NCT06269146RecruitingPhase 2
Pramipexole to improve social connections
This study tests if a medication called pramipexole can help people with anxiety or depression who also find it difficult to connect socially. It looks at whether the drug can improve your motivation for social interactions and help you feel more connected.
San Diego, CaliforniaAges 18–50 - NCT07299903Recruiting
Sleep hygiene education study for menopausal women
This study tests if an online sleep hygiene program can improve sleep quality and reduce depression in menopausal women. It is designed for those with low sleep quality and access to a smartphone or computer.
AnkaraAges 45–60 - NCT06752759RecruitingPhase 3
Ketamine mist for depression
This trial tests if a ketamine mist you breathe in can help treat moderate to severe depression. It is for adults who are not helped enough by other treatments.
Brooklyn, New YorkAges 18–88 - NCT07717541Recruiting
Virtual poetry workshops for anxiety and stomach issues
This study tests if joining a facilitated online poetry workshop can help reduce anxiety and improve well-being for people with stomach discomfort. You would attend virtual group sessions and share poems you create.
Columbus, OhioAges 18 years+ - NCT05523817Recruiting
Brain scan targeting to improve specific depression symptoms
This study uses brain-signal targeting (likely with MRI) to see whether it can improve certain symptoms of depression. You may be able to join if you’re 18–65 and currently have a depressive episode, and if you can safely complete the scan.
Boston, MassachusettsAges 18–65
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Common questions
- Are there clinical trials for depression and anxiety symptom?
- Yes. Clin2 currently lists 181 recruiting depression and anxiety symptom studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a depression and anxiety symptom trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a depression and anxiety symptom trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.