Clinical trials
Depression and Anxiety Symptom clinical trials
Below are recruiting depression and anxiety symptom clinical trials, each written for real people, not researchers. We’re tracking 180 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06441786Recruiting
Group therapy for depression and anxiety in autistic teens
This trial tests a group therapy that helps teenagers with autism who also have anxiety or depression learn skills to manage their thoughts and feelings. It takes place at a clinic in Stockholm.
Haninge, Stockholm CountyAges 15–18 - NCT06776887Recruiting
Virtual reality exercises for burn recovery on legs
This trial tests whether virtual reality exercises can help people with leg burns improve balance and reduce depression and anxiety. It is for people who had a large thermal burn on their lower body at least 3 months ago.
GizaAges 35–55 - NCT07748091Recruiting
Brain wave and inflammation markers in shock therapy for depression
This study looks at brain wave patterns and markers of inflammation in people with depression that hasn't improved with other treatments and who are receiving electroconvulsive therapy (ECT, also known as shock therapy). The goal is to understand how these markers might relate to how well ECT works.
Istanbul, BakırköyAges 18–60 - NCT07740694Recruiting
ECT study for older adults with depression
This study looks at how ECT affects brain activity and inflammation in older adults with depression. It may help researchers understand why ECT works and improve treatment.
Istanbul, BakırköyAges 55 years+ - NCT05567640Recruiting
Smart digital mental health support
This study tests a digital mental health program that uses smart technology to personalize your experience and keep you engaged. If you join, you may get a more tailored approach to improving your mental well-being.
Boston, MassachusettsAges 18 years+ - NCT07731568Recruiting
Group nature therapy for anxiety in college students
This trial tests whether a type of talk therapy done in nature groups can help reduce anxiety symptoms. It is for college students who feel anxious but not severely depressed or at risk of suicide.
Beijing, Beijing MunicipalityAges 18–30 - NCT07717385Recruiting
90-day trial of a probiotic for stress and sleep
This study tests whether a daily probiotic capsule called Neuralli Mood can help adults who feel stressed, have trouble sleeping, or experience low mood. It lasts 90 days and involves taking two capsules each day and filling out online surveys.
New York, New YorkAges 18 years+ - NCT04245436RecruitingPhase 4
Testing antidepressants for teens with anxiety
This trial studies whether an antidepressant can help teens (ages 12–17) with anxiety disorders such as generalized, social, separation, or panic anxiety. It looks at both early and longer-term success of treatment, while monitoring safety closely with a caregiver.
Cincinnati, OhioAges 12–17 - NCT04478305RecruitingPhase 1
Duavive trial for mood and anxiety in midlife women
This Phase 1 study tests Duavive’s effects on mood and anxiety symptoms in women going through perimenopause or early menopause. It may help clarify whether this treatment can reduce depression and/or anxiety symptoms in midlife.
Hamilton, OntarioAges 45–60 - NCT05549102Recruiting
CBT therapy study for anxiety and brain circuit changes
This trial studies whether a specific form of talk therapy (CBT) changes brain activity in people with moderate anxiety. It may help your care team understand what works best and how brain “circuits” respond to treatment.
LondonAges 18–64 - NCT05589337Recruiting
Baduanjin exercise program for depression and anxiety symptoms
This study tests whether practicing Baduanjin (a gentle movement/exercise) can reduce symptoms of depression and anxiety. It may help people who are able to follow instructions and communicate clearly.
Shanghai, Shanghai MunicipalityAges 18–70 - NCT05658796Recruiting
Program to reduce opioid use after hip or knee replacement
This trial tests a support program called RXWell to help people use less opioid pain medicine after elective hip or knee replacement surgery. It may help by addressing anxiety and depression symptoms that can affect pain and recovery.
Monroeville, PennsylvaniaAges 18–100 - NCT05754151Recruiting
Mobile therapy for anxiety and depression in adults 40+
This trial tests whether a phone or tablet version of cognitive behavioral therapy (CBT) can help people ages 40 and older with anxiety or depression. It may help you manage symptoms with skills you can use between sessions.
New York, New YorkAges 40 years+ - NCT05800522Recruiting
Supportive parenting program for kids with behavior and mood struggles
This trial tests whether a supportive parenting program can help children who are showing higher-than-usual symptoms like anxiety, depression, anger, or behavior problems. If you’re not already in certain specialized mental health programs, your child may be able to join and get structured support for coping.
OsloAges 4–12 - NCT05836090Recruiting
Family Spirit Strengths program for pregnant people and caregivers
This trial tests a family-focused program to support mental health and reduce risks related to substance use. It may help you if you’re pregnant or caring for a child 24 months or younger and you’re experiencing depression/anxiety and/or substance-use risk.
Chinle, ArizonaAges 14 years+ - NCT05855421Recruiting
Ear acupuncture sessions for moderate depression during COVID
This trial tests whether auricular (ear) acupuncture can safely improve symptoms of moderate depression during the COVID period. You may be able to join if you’re an adult with moderate depression and can attend the study sessions.
Palhoça, Santa CatarinaAges 18–50 - NCT06004115RecruitingPhase 4
Brain scanning study for depression and anxiety
This study uses brain scans (fMRI) to understand how people with both depression and anxiety respond to threat. If you have either or both conditions, participating could help researchers find better treatments.
Tulsa, OklahomaAges 18–65 - NCT06078007Recruiting
App for depression and anxiety in college students
This trial tests if a guided mobile app can help college students with mild to moderate depression or anxiety. You might benefit if you are not currently receiving mental health treatment and have a smartphone.
Palma de Mallorca, Balearic IslandsAges 18 years+ - NCT06358495Recruiting
Sleep improvement to prevent depression and anxiety in teens
This study tests if improving sleep can help prevent depression and anxiety in teens who are at higher risk because a parent has had depression or anxiety. It's for teens who have trouble sleeping but don't have a history of depression or anxiety themselves.
Calgary, AlbertaAges 12–18 - NCT06462196Recruiting
Study of Depression, Bipolar Disorder & Suicide Risk
This study looks at how depression, bipolar disorder, and suicide risk naturally change over time. It aims to better understand these conditions so doctors can improve treatments.
Bethesda, MarylandAges 18–120 - NCT06592573Recruiting
Anxiety and depression support for cancer caregivers
This trial tests whether online or in-person support can help reduce anxiety and depression symptoms in people caring for a loved one with cancer. You may be eligible if you're feeling anxious or down and are not currently in therapy.
Bologna, BOAges 18 years+ - NCT06632782Recruiting
Breathing exercise for anxiety and depression in type 2 diabetes
This study tests whether a simple breathing exercise (pyramid breath awareness) can help reduce anxiety and depression symptoms in people with type 2 diabetes. It is a short, non-drug program that may offer a natural way to feel better emotionally.
Kuwait City, KuwaitAges 30–80 - NCT06706323Recruiting
Depression after heart surgery study
This study looks at depressive symptoms in people who have had heart bypass surgery. It aims to understand how patients feel emotionally after surgery and may help improve care.
ZurichAges 18–90 - NCT06724666Recruiting
Online therapy for teens with anxiety or depression
This study tests an online therapy program for teens aged 13–17 who feel anxious, depressed, or both. The program is designed to help you understand and manage these feelings through short, internet-based sessions, and you can do it from home.
Cluj-NapocaAges 13–17
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Common questions
- Are there clinical trials for depression and anxiety symptom?
- Yes. Clin2 currently lists 180 recruiting depression and anxiety symptom studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a depression and anxiety symptom trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a depression and anxiety symptom trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.