Clinical trials
Depression, Anxiety clinical trials
Below are recruiting depression, anxiety clinical trials, each written for real people, not researchers. We’re tracking 479 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT05838404Recruiting
Program to support mental health during early pregnancy
This study tests an intervention meant to improve mental health for people during pregnancy, starting in the first part of pregnancy. You might be able to join if you are already receiving prenatal care and speak English or Spanish.
New Orleans, LouisianaAges 18 years+ - NCT05845541Recruiting
Meditation and body feedback for mood after stroke
This study tests whether guided meditation and biofeedback can improve anxiety, depression, and quality of life for people recovering in inpatient rehab after a recent stroke. It may help you feel better emotionally and cope more easily during recovery.
Toronto, OntarioAges 18 years+ - NCT05883540RecruitingPhase 2
LSD therapy in palliative care for comfort and well-being
This Phase 2 study tests how LSD may affect comfort and quality of life for people with advanced or end-stage life-limiting illness. It also checks whether the medicine is safe and can be given in a controlled way in palliative care settings.
BaselAges 22 years+ - NCT05898516Recruiting
JoyPop mental health app for Indigenous teens on a waitlist
This trial studies a mobile mental health app called JoyPop for Indigenous teens (ages 12–17) who are waiting to get mental health support. It may help by offering accessible support while they wait for services.
Thunder Bay, OntarioAges 12–17 - NCT05908565Recruiting
Digital therapy program for Latinx college students in East LA
This study tests a digital (online) prevention and therapy program called STAND to see if it improves engagement and outcomes. You may be able to participate if you’re a Latinx student at East Los Angeles College and can complete online assessments.
Los Angeles, CaliforniaAges 18–40 - NCT05942469Recruiting
Online study for emotion skills to prevent secondary trauma
This study tests an online program to help people regulate their emotions, aiming to reduce “secondary trauma” from their work. You may be able to join if you meet the simple eligibility needs below.
Chicago, IllinoisAges 18 years+ - NCT05991154Recruiting
JoyPop app study for Indigenous young adults on a wait-list
This study tests a mobile app called JoyPop designed to help improve mental health and well-being. It is for Indigenous young adults who are waiting for counseling services at Dilico Anishinabek Family Care.
Thunder Bay, OntarioAges 18–25 - NCT06004414Recruiting
SilverCloud mental health app study for high school students
This study tests a mental health app called SilverCloud in high school students who are feeling anxious or depressed. It aims to see if the app can help improve their mood and wellbeing.
New Brunswick, New JerseyAges 13–22 - NCT06030154Recruiting
Boosting positive feelings for people with alcohol use disorder
This study tests a program designed to help people with alcohol use disorder who also struggle with low mood or anxiety. It aims to increase positive emotions, which may make it easier to reduce drinking.
Tulsa, OklahomaAges 18–65 - NCT06046586Recruiting
Online therapy for cancer survivors with anxiety or depression
This trial tests an online therapy program for cancer survivors who feel anxious, depressed, or worried about cancer coming back. It's a text-based program you can do from home.
StockholmAges 18 years+ - NCT06049420Recruiting
Lifestyle medicine for rural patients with chronic disease
This trial tests whether exercise therapy can help people with two or more chronic conditions like obesity, diabetes, or heart disease. It's designed for rural patients and requires a referral from your doctor.
Lewisburg, West VirginiaAges 18–64 - NCT06060860Recruiting
Comparing two therapies for autistic adults with depression or anxiety
This study compares two types of talk therapy — cognitive-behavioral therapy (CBT) and mindfulness-based therapy — to see which works better for autistic adults who also have depression or anxiety. You would attend online sessions from home.
Chapel Hill, North CarolinaAges 18 years+ - NCT06121284RecruitingPhase 2
Brain stimulation plus medication for youth suicide
This study tests if a new type of brain stimulation (iTBS) combined with a medicine called D-cycloserine can reduce suicidal thoughts in young adults who have previously attempted suicide. It aims to find a faster, mood-boosting treatment option for young people at risk.
Calgary, AlbertaAges 18–24 - NCT06123325Recruiting
Mental health and quality of life after unruptured brain aneurysm diagnosis
This trial looks at how being diagnosed with an unruptured brain aneurysm (a weak spot on a blood vessel that hasn't bled) affects your mood, anxiety, and quality of life. It also compares outcomes for people who get treatment (like surgery or a catheter procedure) versus those who are watched with scans.
The Bronx, New YorkAges 18–75 - NCT06162741Recruiting
Brief mindfulness training for Veterans in primary care
This study tests whether brief mindfulness training offered in VA primary care can help Veterans with symptoms of PTSD, depression, or anxiety. It aims to see if this approach works well in everyday clinic settings.
Phoenix, ArizonaAges 18 years+ - NCT06178328Recruiting
Online mental health program for Canadian adults
This study is testing a short online mental health program for adults in Canada who are seeking help. It aims to see if the program helps people feel better.
Regina, SaskatchewanAges 18 years+ - NCT06197711Recruiting
PRISMA for mental health in pretrial detention
This study tests whether a program called PRISMA can help improve mental health for people in pretrial detention. It is designed for detainees in Zurich and Bern who speak one of nine languages and are not in immediate crisis.
Zurich, Canton of ZurichAges 18 years+ - NCT06200155RecruitingPhase 2
Psilocybin therapy for advanced cancer patients with anxiety or depression
This trial tests whether a drug called psilocybin, given with therapy, can help people with advanced cancer who are feeling anxious or depressed. You must have a stable cancer and be willing to travel to Houston for treatment.
Houston, TexasAges 25 years+ - NCT06226155Recruiting
HIV prevention support for pregnant women in Zimbabwe
This study in Zimbabwe tests a program to help pregnant women start and stay on PrEP (medication that prevents HIV). It aims to make PrEP easier to use during pregnancy for women who are at risk of HIV.
HarareAges 15–55 - NCT06236919Recruiting
Virtual reality for emotional regulation in kids and teens
This study tests a virtual reality program designed to help children and teens learn to manage their emotions. It's offered in schools and aims to improve emotional regulation skills.
BarcelonaAges 10–16 - NCT06239545Recruiting
JoyPop app for mental health support in young adults
This trial tests a mobile app called JoyPop designed to help young adults manage their mental health while they wait for services. It aims to see if using the app can improve well-being and reduce distress.
Thunder Bay, OntarioAges 18–25 - NCT06239519Recruiting
JoyPop mobile app for youth mental health
This trial is testing a mobile app called JoyPop to help youth with their mental health while they wait for counselling. Participants use the app for a few weeks and share feedback.
Thunder Bay, OntarioAges 12–17 - NCT06248203Recruiting
Teacher-led mental health support for teens in Darjeeling
This trial tests a program in which teachers get extra training to support students with emotional or behavioral challenges in low-cost private schools in Darjeeling. It aims to see if teachers can make a positive difference for these teens.
Darjeeling, West BengalAges 13 years+ - NCT06250842Recruiting
Benzodiazepine impact on brain function study
This study uses brain scans to understand how long-term benzodiazepine use affects thinking and memory. It compares people who have taken benzodiazepines for at least 3 months with those who have not.
Dalian, LiaoningAges 18–80
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Common questions
- Are there clinical trials for depression, anxiety?
- Yes. Clin2 currently lists 479 recruiting depression, anxiety studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a depression, anxiety trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a depression, anxiety trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.