Clinical trials
Depression Symptoms clinical trials
Below are recruiting depression symptoms clinical trials, each written for real people, not researchers. We’re tracking 194 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06589544Recruiting
Virtual reality and brain stimulation for depression in cancer patients
This trial tests whether combining virtual reality therapy with transcranial magnetic stimulation (a non-invasive brain treatment) can help reduce depression in people who have had cancer in the last 5 years. It aims to improve mood without using medication.
Ferrara, FEAges 18–100 - NCT06203899Recruiting
Depression and suicide prevention for teens in special schools
This study tests a program to prevent depression and suicide in teens at special schools. It helps if you've had some symptoms but aren't already getting treatment.
Boekel, Noordoost BrabantAges 12–18 - NCT07569133Enrolling by invitation
Brain Stimulation to Reduce Depression in Parkinson's Disease
This study tests whether repetitive transcranial magnetic stimulation (rTMS)—a non-invasive brain stimulation technique—can safely reduce depressive symptoms in people with Parkinson's disease. If it works, it could offer a new treatment option for depression that often accompanies Parkinson's.
Daegu, Buk-guAges 40–90 - NCT07474363Recruiting
Depression differences between men and women
This study looks at how depression affects men and women differently, including symptoms, strength to cope (resilience), and feelings of stigma. It aims to understand these differences to improve treatment.
Eskişehir, EskişehirAges 18–65 - NCT06078007Recruiting
App for depression and anxiety in college students
This trial tests if a guided mobile app can help college students with mild to moderate depression or anxiety. You might benefit if you are not currently receiving mental health treatment and have a smartphone.
Palma de Mallorca, Balearic IslandsAges 18 years+ - NCT07007247Enrolling by invitation
Digital aftercare for teens with depression after hospital discharge
This pilot study tests a digital program to support adolescents aged 12–17 with depression after they leave the hospital. It aims to help prevent relapse and improve well-being using a smartphone, tablet, or computer.
HamburgAges 12–17 - NCT06442423RecruitingPhase 1
Psilocybin study for people with psychiatric symptoms
This trial tests if psilocybin, a substance found in certain mushrooms, can help people with various mental health symptoms that affect daily life. You would take a single dose in a supervised setting and be monitored for changes in your mood and well-being.
New Haven, ConnecticutAges 18 years+ - NCT07047820Recruiting
Studying zuranolone for postpartum depression after pregnancy
This study looks at how the medicine zuranolone (taken for postpartum depression) works in real life for people who got a prescription within a year after their pregnancy ended. Researchers want to see if symptoms improve and how participants feel while taking it.
Woonsocket, Rhode IslandAges 18 years+ - NCT07651436Recruiting
Depression screening in patients on kidney dialysis
This study tests whether nurses can effectively screen for depression in patients receiving regular kidney dialysis treatment. The goal is to find the best way to identify depression early so patients can get help.
AnnecyAges 18 years+ - NCT06752759RecruitingPhase 3
Ketamine mist for depression
This trial tests if a ketamine mist you breathe in can help treat moderate to severe depression. It is for adults who are not helped enough by other treatments.
Brooklyn, New YorkAges 18–88 - NCT07241325Recruiting
Emotional health and quality of life in type 2 diabetes
This study looks at how adults with type 2 diabetes feel emotionally and mentally, and how their health affects their daily life. Participants will fill out questionnaires about their mood, well-being, and quality of life.
TaipeiAges 18 years+ - NCT07745920Recruiting
An online program for depression in people with adpkd
This study tests an internet-based program to help manage depression symptoms in people with ADPKD. The program may be a convenient way to get support for your mood without traveling to a clinic.
Rochester, MinnesotaAges 18–70 - NCT06248710RecruitingPhase 2/Phase 3
Dog presence and oxytocin spray for trust in therapy
This study explores whether being with a friendly dog and getting a nasal spray of oxytocin (a natural hormone) can help you feel more trust toward a therapist. It's looking for healthy adults who are comfortable around dogs.
Basel, Canton of Basel-CityAges 18 years+ - NCT05219955Recruiting
Study of caregiver stress and sleep in older adults
This study looks at how caregiver stress affects sleep problems—especially trouble getting going in the morning. If you are a caregiver for someone with dementia and have specific morning sleep/energy difficulties, you may be able to join and help researchers better understand what helps.
Pittsburgh, PennsylvaniaAges 55 years+ - NCT06413849Recruiting
Phone coaching with a picture-story book for dementia caregivers
This study tests if talking with a coach by phone and reading a story-based book can help family caregivers of people with dementia feel better. You'll get a free book and weekly coaching calls to help manage your mood.
Hong Kong SARAges 18 years+ - NCT07020572Recruiting
Teen mood support program (iMATTER) in primary care
This study tests a group program to help teenagers with mild to moderate depression symptoms feel better. It takes place in primary care and uses a phone, computer, or tablet for activities.
Philadelphia, PennsylvaniaAges 13–17 - NCT07471529Recruiting
Social support app for psychotherapy patients
This trial tests a smartphone app that helps you get social support while you wait for outpatient therapy. It is for people with mild to moderate depression who are not starting therapy right away.
Zurich, Canton of ZurichAges 18–70 - NCT07415941Recruiting
Mindfulness and nerve stimulation for back pain and depression
This trial tests if combining mindfulness-based meditation with a gentle nerve stimulation device (applied to the ear) can help people aged 50–85 with chronic low back pain and depression. The goal is to reduce pain and improve mood without changing your current medications.
Tallahassee, FloridaAges 50–85 - NCT06888284Enrolling by invitation
Tuijing therapy for depression and heart rate
This trial tests whether Tuijing therapy, a non-invasive treatment, can improve heart rate variability and reduce depression symptoms in people who have been feeling depressed for over three months. It may be an option if you haven't used other treatments recently.
Hong KongAges 18–60 - NCT06528132Recruiting
Mindfulness for older adults with low mood
This trial tests a social worker-led mindfulness program for older adults with mild to moderate depressive symptoms. The goal is to see if it helps improve mood and well-being.
Eastern DistrictAges 60 years+ - NCT06882798Recruiting
New support program for Latinx teens with suicidal thoughts
This study tests a new support program for Latinx teens who have had serious thoughts about suicide or a suicide crisis in the past year. It involves working with both you and your family to find ways to help you feel safer and more supported.
Providence, Rhode IslandAges 12–18 - NCT06631781Recruiting
Study on thinking skills in older adults with depressive symptoms
This study tests whether a tablet-based program can help older adults with depressive symptoms improve their thinking and control skills. If you have low mood and are comfortable with a tablet, you may be able to join.
JerusalemAges 65 years+ - NCT07467564Recruiting
Does Dupilumab help anxiety and depression in eczema?
This study looks at whether Dupilumab (a treatment for moderate-to-severe eczema) can also help improve symptoms of anxiety and depression. It is for people with eczema who also have these mood symptoms and are about to start Dupilumab.
DohaAges 12 years+ - NCT07719517Recruiting
Morning activities to boost mood after stroke
This study tests if doing simple, guided activities in the morning can help improve your mood after a stroke. If you often feel down and have trouble getting going in the morning, this program might offer a way to feel better.
Hong KongAges 18 years+
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Common questions
- Are there clinical trials for depression symptoms?
- Yes. Clin2 currently lists 194 recruiting depression symptoms studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a depression symptoms trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a depression symptoms trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.