Clinical trials · California
Depression clinical trials in California
We’re tracking 132 recruiting depression studies with a site in California, each written for real people, not researchers.
Recruiting studies in California
- NCT07186816Recruiting
Peer support for Spanish-speaking adults with anxiety or depression
This trial tests whether peer support from someone who has been through similar struggles can help reduce anxiety and depression symptoms. It's for Spanish-speaking adults who have internet access and are not currently in talk therapy.
San Francisco, CaliforniaAges 18–100 - NCT07346638Recruiting
Trauma therapy for women with suicidal thoughts
This trial tests a group therapy program called BEAR for women who have experienced trauma and are currently having suicidal thoughts. The program aims to help reduce distress and improve coping.
Stanford, CaliforniaAges 18–75 - NCT07364799Recruiting
Sound therapy for stress in detained teens
This trial tests a multi-sensory therapy called SoundHeal for teens in juvenile detention. It uses sound and vibration to help with stress, anxiety, depression, or substance use.
San Luis Obispo, CaliforniaAges 12–18 - NCT07528014Recruiting
Tracking Depression Treatment Outcomes Over Time
This study follows adults receiving depression treatment (esketamine, TMS, or SAINT) to understand how these therapies work and their effects over time. Researchers will assess mood, functioning, and other factors to help improve future treatment.
La Jolla, CaliforniaAges 18 years+ - NCT07369180Enrolling by invitation
TMS for treatment-resistant depression in adults
This study tests a new type of transcranial magnetic stimulation (TMS) for adults whose depression hasn't gotten better with medication. It compares the real treatment to a sham (inactive) version to see how well it works.
Campbell, CaliforniaAges 22–85 - NCT06823024Enrolling by invitation
Using speech patterns to predict treatment response in depression, PTSD, or bipolar disorder
This study tests if a computer algorithm can analyze your speech to predict how well you will respond to treatments like TMS or Spravato. It aims to create a simple tool that helps doctors choose the right treatment for you.
Sunnyvale, CaliforniaAges 18–68 - NCT06583395Enrolling by invitation
Meditation retreat study with fitness tracker
This trial studies people attending a 7-day meditation retreat to see how meditation affects well-being. You will wear a fitness tracker and answer surveys.
Palm Desert, CaliforniaAges 21 years+ - NCT06430853Enrolling by invitation
Pregnancy support study for moms with anxiety or depression
This study tests if a mental health program during pregnancy can help mothers with past or current anxiety or depression. You'll get support and you may feel better and have a healthier pregnancy.
Stanford, CaliforniaAges 18 years+ - NCT05746767Enrolling by invitation
Spanish digital therapy coaching for depression and anxiety
This study tests a digital “cognitive behavioral therapy” program with peer support to help Spanish-speaking adults with depression or anxiety. It may help you manage symptoms using structured online tools and guided peer interaction.
Irvine, CaliforniaAges 18 years+ - NCT05152992Enrolling by invitation
Studying brain networks during epilepsy surgery planning
This study looks at how emotion-related brain connections change in space and over time while people with epilepsy are having surgery-related electrodes placed to find seizure sources. It may help researchers better understand brain networks and improve future treatment planning.
San Francisco, CaliforniaAges 18–80 - NCT04356274Enrolling by invitation
Improving access to addiction and mental health care at VA clinics
This study tests an approach to help VA clinics reach more Veterans with proven treatments for addiction and mental health conditions. It focuses on clinic-level processes (not individual medications) to increase how widely evidence-based care is delivered.
Palo Alto, CaliforniaAges 18 years+ - NCT04040062Enrolling by invitation
Tested deep brain–stimulating treatment for hard-to-treat depression
This study tests a specialized type of magnetic brain stimulation (spectral TMS) to treat severe major depression when standard treatments haven’t worked. You may be eligible if you’ve tried several antidepressants and other add-on treatments but still have symptoms.
Los Angeles, CaliforniaAges 18–65
Depression trials by city in California
Where these studies are running in California
Institutions with a site for the recruiting depression studies listed above.
- Stanford University · 2 studies
- Zuckerberg San Francisco General Hospital and Trauma Center · 2 studies
- Acacia Clinics
- Castro-Mission Health Center
- LGTC Group
- Salma Health
- San Luis Obispo County Juvenile Hall
- Silver Avenue Family Health Center
What taking part in a depression study involves
A screening visit first
Before anything else, the study team checks whether you fit — usually a visit with some tests. You can stop at any point, and screening is typically free.
Care at a nearby site
Study visits happen at a clinic or hospital taking part. Many studies cover the cost of the study treatment and related visits, and some reimburse travel.
You stay in control
Taking part is voluntary and you can leave a study at any time, for any reason, without affecting your regular care.
The team decides eligibility
Our fit check is a helpful first read, not a decision. The study team makes the final call after reviewing your health history.
Depression trials in other states
Common questions
- Are there depression clinical trials in California?
- Yes. We're currently tracking 132 recruiting depression studies with a site in California, each rewritten in plain language so you can see what it's testing and who it's for.
- How do I find out if I qualify for a depression study in California?
- Each study lists its eligibility rules — age, diagnosis, prior treatments. On every trial page we explain these in plain language and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Do I have to live in California to take part?
- Not necessarily. These studies have a site in California, but eligibility is about your health, not your address — some people travel to take part, and a few studies reimburse travel. The study team can tell you what's required.
- Does it cost anything to join a depression trial?
- Using Clin2 is always free. Many trials cover the study treatment and related visits; some reimburse travel. The study team explains exactly what's covered before you decide.
Not the right time?
New depression studies open in California regularly. Set up a health profile and we’ll quietly watch for studies that fit you and email you when one opens.
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.