Clinical trials · North Carolina
Depression clinical trials in North Carolina
We’re tracking 36 recruiting depression studies with a site in North Carolina — including Phase 2, Phase 3 and Phase 4 studies, each written for real people, not researchers.
Recruiting studies in North Carolina
- NCT07822321RecruitingPhase 3
Brexanolone for severe postpartum depression
This trial tests an investigational medicine to help mothers with severe depression that started late in pregnancy or shortly after childbirth. It aims to improve mood and overall well-being.
Chapel Hill, North CarolinaAges 15–45 - NCT07282678Recruiting
Adaptive brain stimulation for treatment-resistant depression.
This study tests a new brain stimulation device that adjusts its signal in real time to treat depression. It's for people who haven't gotten enough help from antidepressants and are looking for a non-drug option.
Durham, North CarolinaAges 22 years+ - NCT07284667RecruitingPhase 2
A new medicine for depression that hasn't improved with other treatments
This trial tests a new medicine called ACP-211 in adults with major depression who have not gotten enough relief from at least two previous antidepressants. The goal is to see if it can help when other treatments have not worked well.
Cary, North CarolinaAges 18–65 - NCT07143838Recruiting
Enhancing deep sleep to help depression
This study tests a gentle brain stimulation method (called transcranial electrical stimulation) during sleep to see if it can improve deep sleep and help with depression symptoms. It is for adults with moderate depression who also have some memory or thinking complaints.
Winston-Salem, North CarolinaAges 40–80 - NCT07050355Recruiting
Brain stimulation and exercise for depression after stroke
This study tests whether combining brain stimulation with aerobic exercise can help treat depression and improve walking in people who have had a stroke at least a year ago. If you have ongoing depressive symptoms and some leg weakness from your stroke, this treatment may help you feel better and walk more easily.
Durham, North CarolinaAges 21 years+ - NCT07573176RecruitingPhase 3
Seltorexant for Depression in Adults and Older Adults
This study tests a new medication called seltorexant as a standalone treatment for major depression. The trial is for adults and older adults who have depression that hasn't improved with other antidepressants or who haven't tried them yet.
Cary, North CarolinaAges 18–74 - NCT07553637RecruitingPhase 2
ALTO-207 for Adults With Hard-to-Treat Depression
This study tests whether a new medication called ALTO-207 can help people with depression that hasn't improved with standard antidepressants. You may qualify if you've tried multiple antidepressants without enough relief and are willing to add this experimental treatment to your current medication.
Charlotte, North CarolinaAges 18–75 - NCT07507370Recruiting
CARED: A fast new treatment plan for depression
This study tests a quick treatment approach for adults with major depression who have not gotten enough help from at least one antidepressant. It aims to see if a new rapid method can improve mood safely.
Chapel Hill, North CarolinaAges 18–70 - NCT06223880RecruitingPhase 4
AXS-05 vs Bupropion to prevent depression relapse
This study tests whether a new drug called AXS-05 can prevent depression from coming back, compared to an older drug called bupropion. If you have major depression and are at risk of relapse, this trial may help you stay well.
Hickory, North CarolinaAges 18–65 - NCT07413874Recruiting
Music therapy over video for depression and hormone disorder
This trial tests if telehealth music therapy can help adults who have both an endocrine autoimmune disease and depression. You'll join sessions from home using Zoom.
Boone, North CarolinaAges 18–65 - NCT07196501RecruitingPhase 3
Study of a new add-on treatment for depression maintenance
This trial tests a new medication (NBI-1065845) added to your current antidepressant to see if it helps maintain improvement in depression. It is for people whose depression hasn't fully responded to their current oral antidepressant.
Charlotte, North CarolinaAges 18 years+ - NCT07115329RecruitingPhase 2
Testing Zelquistinel for major depression
This study tests a new oral medication called Zelquistinel (taken as a tablet) against a placebo for treating major depressive disorder. Researchers want to see if it can reduce depression symptoms, especially when other antidepressants haven't been tried or haven't worked.
Raleigh, North CarolinaAges 18–64 - NCT06963021RecruitingPhase 3
Study of NBI-1065845 for depression that hasn't fully responded to treatment
This trial tests an investigational drug called NBI-1065845 added to your current antidepressant. It is for people with moderate to severe depression or persistent depressive disorder who have not improved enough with oral antidepressants alone.
Charlotte, North CarolinaAges 18 years+ - NCT06830044RecruitingPhase 3
Adding an experimental drug for major depression
This trial tests if adding a new medicine called milsaperidone can help people with major depression who haven't gotten enough relief from their current antidepressant. It aims to see if the combination works better than the antidepressant alone.
Charlotte, North CarolinaAges 18–65 - NCT06759558RecruitingPhase 2
Zuranolone for post-stroke depression
This trial tests a new medicine called zuranolone (allopregnanolone) for people with depression after a stroke. It aims to see if the drug can help improve mood when taken over a short period.
Durham, North CarolinaAges 21–65 - NCT06696001Recruiting
Brain Study of Talk Therapy for Depression
This study looks at how your brain works during talk therapy for depression. It aims to find out how therapy helps you feel better so that future treatments can be more personalized.
Chapel Hill, North CarolinaAges 18–30 - NCT06656416RecruitingPhase 2
Study of ALTO-100 for bipolar depression
This study tests an investigational drug called ALTO-100 for people with bipolar disorder who are currently experiencing depression. It aims to see if ALTO-100 can help improve depressive symptoms when added to your current mood stabilizer or antipsychotic medication.
Cary, North CarolinaAges 18–70 - NCT06610305RecruitingPhase 4
Hormones, mood, and reward in women with PMS-related depression
This study looks at how changes in hormone levels during the menstrual cycle affect mood and the brain's reward system in women with depression that gets worse before their period. The goal is to understand why this happens so better treatments can be developed.
Chapel Hill, North CarolinaAges 18–45 - NCT06559306RecruitingPhase 3
Seltorexant for depression with insomnia symptoms
This trial tests if adding seltorexant to your current antidepressant can improve depression and sleep problems. It is for people with major depressive disorder who still have symptoms, especially insomnia, despite trying at least one antidepressant.
Hickory, North CarolinaAges 18–74 - NCT06188923RecruitingPhase 2
Pregnenolone for anxiety and depression in veterans
This study tests whether a dietary supplement called pregnenolone can improve day-to-day function in veterans struggling with anxiety and depression. It is a 12-week program that combines the supplement with your usual care, and the goal is to help you feel better and do more of what matters to you.
Durham, North CarolinaAges 18–65 - NCT05976347RecruitingPhase 4
Treatment for depression after certain bone fractures
This trial tries to find and treat depression in people who have recently had surgery for an arm, leg, or pelvis fracture. It may help by screening for depression soon after surgery and offering a new depression treatment approach if you qualify.
Winston-Salem, North CarolinaAges 18 years+ - NCT05851898RecruitingPhase 4
Tested medicine to prevent depression after hip or leg fractures
This trial studies whether a type of antidepressant medicine (a serotonin–norepinephrine reuptake inhibitor) can prevent depression after a lower-extremity fragility fracture that was treated with surgery. It’s mainly for older adults, and aims to see if starting this medicine early reduces later depression symptoms.
Winston-Salem, North CarolinaAges 65 years+ - NCT04777357RecruitingPhase 3
Cariprazine for bipolar depression in ages 10 to 17
This Phase 3 study tests whether cariprazine can improve depression symptoms in children and teens with bipolar I disorder, and also tracks side effects. It may help if your depressive episode is ongoing and you meet specific mood and screening score requirements.
Kinston, North CarolinaAges 10–17 - NCT03887715Recruiting
VNS device for long-term depression that hasn’t improved
This trial studies whether a vagus nerve stimulation (VNS) device can reduce symptoms of treatment-resistant depression. Participants either receive the VNS treatment or a no-stimulation control, to compare safety and effectiveness.
Cary, North CarolinaAges 18 years+
Depression trials by city in North Carolina
Where these studies are running in North Carolina
Institutions with a site for the recruiting depression studies listed above.
- Wake Forest University Health Sciences · 3 studies
- Carolina Center for Neurostimulation · 2 studies
- Magnolia Clinical Research · 2 studies
- Neurocrine Clinical Site · 2 studies
- Appalachian State University
- Clinical Research Site
- Duke South Neurology Clinic 1L
- Duke University School of Medicine
What taking part in a depression study involves
A screening visit first
Before anything else, the study team checks whether you fit — usually a visit with some tests. You can stop at any point, and screening is typically free.
Care at a nearby site
Study visits happen at a clinic or hospital taking part. Many studies cover the cost of the study treatment and related visits, and some reimburse travel.
You stay in control
Taking part is voluntary and you can leave a study at any time, for any reason, without affecting your regular care.
The team decides eligibility
Our fit check is a helpful first read, not a decision. The study team makes the final call after reviewing your health history.
Depression trials in other states
Common questions
- Are there depression clinical trials in North Carolina?
- Yes. We're currently tracking 36 recruiting depression studies with a site in North Carolina, each rewritten in plain language so you can see what it's testing and who it's for.
- How do I find out if I qualify for a depression study in North Carolina?
- Each study lists its eligibility rules — age, diagnosis, prior treatments. On every trial page we explain these in plain language and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Do I have to live in North Carolina to take part?
- Not necessarily. These studies have a site in North Carolina, but eligibility is about your health, not your address — some people travel to take part, and a few studies reimburse travel. The study team can tell you what's required.
- Does it cost anything to join a depression trial?
- Using Clin2 is always free. Many trials cover the study treatment and related visits; some reimburse travel. The study team explains exactly what's covered before you decide.
Not the right time?
New depression studies open in North Carolina regularly. Set up a health profile and we’ll quietly watch for studies that fit you and email you when one opens.
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.