Clinical trials · Pennsylvania
Depression clinical trials in Pennsylvania
We’re tracking 62 recruiting depression studies with a site in Pennsylvania — including Phase 1, Phase 2 and Phase 3 studies, each written for real people, not researchers.
Recruiting studies in Pennsylvania
- NCT06793397RecruitingPhase 3
Study of an experimental psychedelic-like drug for depression (CYB003)
This study tests an investigational medication (CYB003) for people with major depression whose current antidepressant isn't working well enough. It looks at whether this treatment can help improve depression symptoms.
Philadelphia, PennsylvaniaAges 18–85 - NCT02434393Recruiting
Studying brain changes in late-life depression and memory decline
This study looks at how thinking and memory change in people with depression later in life, using brain imaging and related assessments. Your past participation and whether your treatments are stable enough around the time of the brain scan may determine whether you can join.
Pittsburgh, PennsylvaniaAges 65 years+ - NCT07373470Recruiting
Pharmacist help with depression meds using your DNA
This trial tests whether a pharmacist can use your genetic information to better manage your depression medications. It may help find the right drug or dose for you.
Pittsburgh, PennsylvaniaAges 18 years+ - NCT07065240RecruitingPhase 2
Study of SPT-300 for major depression with or without anxiety
This trial tests an experimental oral medication, SPT-300, for people with major depressive disorder, even if they also have mild anxiety. The goal is to see if it helps improve mood safely.
Allentown, PennsylvaniaAges 18–65 - NCT05658796Recruiting
Program to reduce opioid use after hip or knee replacement
This trial tests a support program called RXWell to help people use less opioid pain medicine after elective hip or knee replacement surgery. It may help by addressing anxiety and depression symptoms that can affect pain and recovery.
Monroeville, PennsylvaniaAges 18–100 - NCT06423430Recruiting
Deep brain stimulation for treatment-resistant depression (TRANSCEND)
This trial tests a new brain stimulation treatment (deep brain stimulation, or DBS) for people with hard-to-treat depression. It aims to see if targeting a specific brain area can help when other treatments have failed.
Philadelphia, PennsylvaniaAges 22–70 - NCT06767566RecruitingPhase 1
Ketamine for depression and pain after cesarean delivery
This study tests whether ketamine, a medicine given during cesarean delivery, can help prevent or reduce postpartum depression and pain. It aims to find the best dose for new mothers.
Pittsburgh, PennsylvaniaAges 18 years+ - NCT07845604RecruitingPhase 2
Testing an anti-inflammatory drug with Lexapro for depression
This study tests whether an anti-inflammatory medication (adalimumab, also known as Humira) can help treat depression when added to Lexapro. It may help people whose depression is linked to higher levels of inflammation in the body.
Philadelphia, PennsylvaniaAges 18 years+ - NCT07775300RecruitingPhase 3
Study of an injectable drug for major depressive disorder
This study tests an investigational drug called brenipatide for major depressive disorder. It is given as a self-injection and is being compared to a placebo to see if it helps improve depression symptoms in people who are already on standard treatment.
Philadelphia, PennsylvaniaAges 18–75 - NCT07610473RecruitingPhase 2
Testing DT-101 as an add-on for depression
This trial tests if a new medication, DT-101, can help when added to your current depression treatment. It's for adults with recurrent depression who may need extra support.
Allentown, PennsylvaniaAges 18–75 - NCT07592689RecruitingPhase 3
DT120 Treatment for Major Depression
This study tests whether a new medication called DT120 can help people with moderate-to-severe depression feel better. You'd take the medication for several weeks while doctors track your mood and symptoms.
Philadelphia, PennsylvaniaAges 18–74 - NCT07573150Recruiting
Pupil Measurements to Predict Breathing Problems After Surgery in Children
This study tests whether measuring how a child's pupils (the dark circles in the eyes) respond to light can predict which children might have breathing problems after receiving pain medication during tonsil surgery. The goal is to help doctors catch and prevent serious breathing issues before they happen.
Pittsburgh, PennsylvaniaAges 3–17 - NCT07412756RecruitingPhase 3
Brenipatide for major depressive disorder
This trial tests a new medication, Brenipatide, to see if it helps people with major depression who are already on a stable treatment. You would need to inject the study drug yourself and complete questionnaires.
Philadelphia, PennsylvaniaAges 18–75 - NCT07300969RecruitingPhase 2
Testing DT-101 for adults with depression
This trial tests a new medicine called DT-101 to see if it helps people with depression. It is for adults who have had more than one depressive episode in their life.
Media, PennsylvaniaAges 18–75 - NCT07226232RecruitingPhase 3
Psilocybin for veterans with treatment-resistant depression
This study tests whether psilocybin (a psychedelic substance) can help veterans with depression that hasn't improved with standard treatments.
Philadelphia, PennsylvaniaAges 18–75 - NCT07196501RecruitingPhase 3
Study of a new add-on treatment for depression maintenance
This trial tests a new medication (NBI-1065845) added to your current antidepressant to see if it helps maintain improvement in depression. It is for people whose depression hasn't fully responded to their current oral antidepressant.
Philadelphia, PennsylvaniaAges 18 years+ - NCT07159061Recruiting
Brain training for depression using neurofeedback
This study tests whether a brain training technique called neurofeedback can help treat depression. By showing your brain activity in real time on a screen, you may learn to control the brain patterns linked to depression and feel better.
Philadelphia, PennsylvaniaAges 18–65 - NCT07115329RecruitingPhase 2
Testing Zelquistinel for major depression
This study tests a new oral medication called Zelquistinel (taken as a tablet) against a placebo for treating major depressive disorder. Researchers want to see if it can reduce depression symptoms, especially when other antidepressants haven't been tried or haven't worked.
Allentown, PennsylvaniaAges 18–64 - NCT06997549Recruiting
Review of mental health treatment outcomes
This study looks back at information from a large database of people who received mental health treatments. It aims to understand how well treatments worked and what factors influenced outcomes.
Malvern, PennsylvaniaAges 5–100 - NCT06976840Recruiting
Rapid antidepressant effects of new brain stimulation methods
This trial tests whether two types of non-invasive brain stimulation can quickly improve depression symptoms. It may be an option for adults with major depression who are not currently taking psychiatric medication.
Pittsburgh, PennsylvaniaAges 18–55 - NCT06966401RecruitingPhase 3
Long-term safety study of a new depression treatment
This study tests a new oral medication (NBI-1065845) added to your current antidepressant to see if it's safe and tolerable over a long period for people with depression that hasn't fully responded to treatment.
Philadelphia, PennsylvaniaAges 18 years+ - NCT06963021RecruitingPhase 3
Study of NBI-1065845 for depression that hasn't fully responded to treatment
This trial tests an investigational drug called NBI-1065845 added to your current antidepressant. It is for people with moderate to severe depression or persistent depressive disorder who have not improved enough with oral antidepressants alone.
Philadelphia, PennsylvaniaAges 18 years+ - NCT06963463Recruiting
Sleep & light therapy for teens with depression
This study tests a program that combines sleep and light therapy to help teens with depression and sleep problems feel better. It focuses on improving your sleep schedule and adding bright light exposure to boost mood.
Philadelphia, PennsylvaniaAges 12–18 - NCT06917339Recruiting
A study looking at past treatment records
This trial looks back at medical records in the TrakStar database to understand how treatments were given. It does not test a new drug, but helps researchers learn from past treatment experiences.
Malvern, PennsylvaniaAges 5–120
Depression trials by city in Pennsylvania
Where these studies are running in Pennsylvania
Institutions with a site for the recruiting depression studies listed above.
- Adams Clinical · 4 studies
- Neurocrine Clinical Site · 3 studies
- University of Pittsburgh · 3 studies
- Draig Clinical Site · 2 studies
- Neuronetics · 2 studies
- Penn Medicine · 2 studies
- Suburban Research Associates · 2 studies
- Bellefield Towers
What taking part in a depression study involves
A screening visit first
Before anything else, the study team checks whether you fit — usually a visit with some tests. You can stop at any point, and screening is typically free.
Care at a nearby site
Study visits happen at a clinic or hospital taking part. Many studies cover the cost of the study treatment and related visits, and some reimburse travel.
You stay in control
Taking part is voluntary and you can leave a study at any time, for any reason, without affecting your regular care.
The team decides eligibility
Our fit check is a helpful first read, not a decision. The study team makes the final call after reviewing your health history.
Depression trials in other states
Common questions
- Are there depression clinical trials in Pennsylvania?
- Yes. We're currently tracking 62 recruiting depression studies with a site in Pennsylvania, each rewritten in plain language so you can see what it's testing and who it's for.
- How do I find out if I qualify for a depression study in Pennsylvania?
- Each study lists its eligibility rules — age, diagnosis, prior treatments. On every trial page we explain these in plain language and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Do I have to live in Pennsylvania to take part?
- Not necessarily. These studies have a site in Pennsylvania, but eligibility is about your health, not your address — some people travel to take part, and a few studies reimburse travel. The study team can tell you what's required.
- Does it cost anything to join a depression trial?
- Using Clin2 is always free. Many trials cover the study treatment and related visits; some reimburse travel. The study team explains exactly what's covered before you decide.
Not the right time?
New depression studies open in Pennsylvania regularly. Set up a health profile and we’ll quietly watch for studies that fit you and email you when one opens.
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.