Clinical trials
Depression clinical trials
A common mood disorder causing persistent sadness and loss of interest. We’re tracking 1,419 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT04940585Recruiting
Study for pregnant women with stress or depression symptoms
This study supports pregnant people who are in their second trimester and have signs of stress, trauma, or depression. The goal is to learn whether the program can help improve emotional well-being during pregnancy.
New York, New YorkAges 18–100 - NCT04956016Recruiting
Compare two rTMS treatments for moderate to severe depression
This study tests whether a classic type of brain stimulation (rTMS) works better or the same as a deeper version for depression that keeps coming back or is ongoing. You may be offered one of the two stimulation options to see which helps reduce depressive symptoms.
PoitiersAges 18 years+ - NCT04877977Recruiting
Long-Term Follow-Up for People With Mood Disorders
This study follows people with mood disorders over a long time to better understand how symptoms and functioning change. You may be able to join if you already agreed to take part in an earlier mood/anxiety study and you meet basic participation needs.
Bethesda, MarylandAges 18–99 - NCT04923685Recruiting
Study looks at blood markers linked to childhood trauma and suicide risk
This study checks whether tiny genetic signals in blood (microRNAs) are linked to childhood maltreatment and thoughts or risk of suicide, especially in people with major depression. It may help researchers understand biological clues that could someday guide better care.
Birmingham, AlabamaAges 18–60 - NCT04864080Recruiting
Online study to measure brain-related signals in pain or depression
This trial uses an online study platform to look for “cognitive biomarkers,” which are measurable patterns in thinking or brain-related responses. It compares people with pain or depression to healthy controls to see how these patterns differ and could help future research or care.
Minneapolis, MinnesotaAges 18 years+ - NCT04877197Recruiting
Home telehealth coaching to improve mood after heart hospitalization
This Phase 3 study tests a home-based telehealth program (behavioral activation coaching) to improve functioning in people who recently left the hospital after a heart-related event and also have major depression. It may help you feel more able to do everyday activities and better manage depression symptoms.
Charleston, South CarolinaAges 21 years+ - NCT02604277Recruiting
Study of suicidal behavior in people with bipolar disorder
This study looks at suicidal thoughts or behaviors in people diagnosed with bipolar disorder. It may help researchers understand what leads to suicidal risk and how to better support safety and treatment.
Atlanta, GeorgiaAges 18–64 - NCT04821544Recruiting
Study of stress in new mothers and how it affects breastmilk
This study looks at how stress in new mothers may change their breastmilk and how that relates to newborn health outcomes. It is specifically recruiting mothers with babies in certain NICUs.
Coeur d'Alene, IdahoAges 18–50 - NCT04752618Recruiting
Support program for mothers with trauma and young children
This study offers a structured support program for mothers dealing with trauma symptoms like PTSD, aiming to improve wellbeing and support parenting. It also involves clinicians connected to the Safe Mothers, Safe Children program.
New York, New YorkAges 18 years+ - NCT04526093Recruiting
Study of medical cannabis using patient symptom reports
This study looks at how medical cannabis affects symptoms like pain, epilepsy, sleep, and anxiety or depression, based on what patients report over time. It may help researchers understand what works in real life when people use verified medical cannabis products.
Toronto, OntarioAges 19 years+ - NCT04441034RecruitingPhase 4
Compare two medicines for long-term pain in real life
This trial compares two types of medicines—anti-convulsants and anti-depressants—for people with persistent pain lasting more than 3 months. It aims to find out which option works better in everyday care and for which patients.
Redwood City, CaliforniaAges 18 years+ - NCT04300998Recruiting
CAR-T therapy study for older adults
This study looks at how well CAR-T cell therapy works and how safely it can be given to older adults. It is for people whose cancer or related blood condition has come back or did not respond, and who are receiving a standard (commercial) CAR-T product.
New York, New YorkAges 60 years+ - NCT04356274Enrolling by invitation
Improving access to addiction and mental health care at VA clinics
This study tests an approach to help VA clinics reach more Veterans with proven treatments for addiction and mental health conditions. It focuses on clinic-level processes (not individual medications) to increase how widely evidence-based care is delivered.
Palo Alto, CaliforniaAges 18 years+ - NCT04335487Recruiting
Online therapy program for PTSD symptoms in public safety workers
This study tests an internet-based cognitive-behavioral therapy (an online talk-therapy style program that helps you manage thoughts and feelings) to reduce PTSD symptoms in public safety personnel. You may be able to join if you have PTSD-like symptoms and can safely take part in online treatment.
Regina, SaskatchewanAges 18 years+ - NCT04106713Recruiting
Understanding change across different psychotherapies for anxiety and depression
This study looks at how people change during different types of psychotherapy for anxiety and depression. It aims to understand which treatments work best for different people.
Singapore, SingaporeAges 18–99 - NCT04127032Recruiting
Online therapy program for public safety workers’ stress and mood
This trial tests an internet-delivered cognitive behavioral therapy (an online talk-and-skills program) to help public safety personnel with symptoms of anxiety, depression, or post-traumatic stress. If you’re eligible, you may receive structured online support aimed at reducing distress and improving coping.
Regina, SaskatchewanAges 18 years+ - NCT04040062Enrolling by invitation
Tested deep brain–stimulating treatment for hard-to-treat depression
This study tests a specialized type of magnetic brain stimulation (spectral TMS) to treat severe major depression when standard treatments haven’t worked. You may be eligible if you’ve tried several antidepressants and other add-on treatments but still have symptoms.
Los Angeles, CaliforniaAges 18–65 - NCT03953014Recruiting
Genetic study of antidepressant side effects in young people
This trial studies whether genes (using a saliva sample) can help explain why some young people feel more “disinhibited” after taking antidepressants like SSRIs. If you’ve had depression, anxiety, or OCD and have used an SSRI, your information and genetics may help improve how antidepressants are chosen and monitored.
Calgary, AlbertaAges 6–17 - NCT03906435Recruiting
Cognitive therapy to prevent problems for very premature NICU babies
This study offers a counseling approach to help prevent “Vulnerable Child Syndrome” in babies born very early and cared for in the NICU. It focuses on support during the early months after birth and compares outcomes for families getting the therapy versus usual support.
Dallas, TexasAges Any age - NCT03794531Recruiting
Study of health, stress, and lifestyle changes in Puerto Rico
This study looks at how people’s health, day-to-day stress, and living conditions in Puerto Rico change over time. You might help researchers understand what trends are happening and what could be improved.
San JuanAges 30–75 - NCT03217110Recruiting
Brain stimulation study for thinking and control
This trial tests whether stimulating the cerebellum (a part of the brain involved in coordination and learning) can improve “cognitive control,” or the ability to focus and manage thoughts. You may be able to join if you have a diagnosis they are specifically enrolling for and you can safely complete the stimulation and study procedures.
Iowa City, IowaAges 18–90 - NCT02726061Recruiting
Online psychological support for depression
This study tests an internet-based (online) psychological support program for adults who are feeling depressed. It may help participants by offering structured support without needing in-person visits.
Lebanon, New HampshireAges 18 years+ - NCT02543983RecruitingPhase 2
Brain scan and ketamine study for suicidal thoughts
This trial studies how ketamine affects the brain in people dealing with suicidal thoughts or an active suicide crisis. It uses questionnaires, consent testing, and brain imaging to look for biological changes that may relate to symptom improvement.
Bethesda, MarylandAges 18–70 - NCT01809080Enrolling by invitation
Intern and medical student health check study
This study looks at the health of new interns and some final-year medical students in several training programs. It may help improve care and support for people early in their medical careers.
Ann Arbor, MichiganAges Any age
Hear when a new Depression trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.
Common questions
- Are there clinical trials for depression?
- Yes. Clin2 currently lists 1,419 recruiting depression studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a depression trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a depression trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.