Clinical trials
Depressive and Anxiety Disorders clinical trials
Below are recruiting depressive and anxiety disorders clinical trials, each written for real people, not researchers. We’re tracking 435 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT05754151Recruiting
Mobile therapy for anxiety and depression in adults 40+
This trial tests whether a phone or tablet version of cognitive behavioral therapy (CBT) can help people ages 40 and older with anxiety or depression. It may help you manage symptoms with skills you can use between sessions.
New York, New YorkAges 40 years+ - NCT07807865RecruitingPhase 3
Testing a new anxiety medication for safety
This study is testing a new medication for generalized anxiety disorder. It will check if the drug is safe and well-tolerated when taken alone or alongside your current anxiety treatment.
Los Angeles, CaliforniaAges 18 years+ - NCT07055061Recruiting
Music for reducing stress, anxiety and depression
This trial tests if listening to specially designed music can help reduce stress, anxiety and depression. It may be a good option for people who are not currently taking medication or receiving treatment.
Beijing, Beijing MunicipalityAges 18–60 - NCT06853587Recruiting
Genetic test to help pick antidepressant for teens
This study tests whether using a cheek swab DNA test can help choose a better antidepressant for teenagers with anxiety or depression. The goal is to see if this personalized approach leads to fewer side effects and better results.
Calgary, AlbertaAges 12–17 - NCT06765057RecruitingPhase 2/Phase 3
Probiotics for Depression and Metabolic Health
This trial tests whether taking a probiotic supplement can improve both depression symptoms and metabolic health (like waist size, blood sugar, and cholesterol) in people with major depression. It may be a good fit if you are already on an antidepressant and have signs of metabolic syndrome.
Riyadh, Riyadh RegionAges 18–65 - NCT06633016RecruitingPhase 2
ABX-002 for major depression (add-on treatment)
This trial tests a new medication called ABX-002 as an add-on to your current antidepressant. It's for people with moderate to severe depression who haven't gotten enough help from their current antidepressant alone.
Birmingham, AlabamaAges 18–65 - NCT06188923RecruitingPhase 2
Pregnenolone for anxiety and depression in veterans
This study tests whether a dietary supplement called pregnenolone can improve day-to-day function in veterans struggling with anxiety and depression. It is a 12-week program that combines the supplement with your usual care, and the goal is to help you feel better and do more of what matters to you.
Durham, North CarolinaAges 18–65 - NCT05843695Recruiting
Therapy study for PTSD and anxiety in veterans
This trial tests a psychotherapy approach to help veterans and service members who have PTSD and/or anxiety disorders. You may be randomly assigned to different therapy conditions, and the study aims to improve quality of life and reduce anxiety and PTSD symptoms.
Houston, TexasAges 18 years+ - NCT04557891Recruiting
Low-intensity ultrasound for generalized anxiety disorder
This trial tests a non-drug brain treatment using low-intensity focused ultrasound to reduce symptoms of generalized anxiety disorder (GAD). It may help if your anxiety has been moderate to severe and you’ve already tried standard medications without enough relief.
Los Angeles, CaliforniaAges 18–65 - NCT03973268RecruitingPhase 1
Ketamine study to understand treatment response in hard-to-treat depression
This early-stage study tests ketamine and looks at what brain changes may explain why it helps people with major depression that hasn’t improved with usual treatments. You may be asked to stay in the hospital and complete detailed interviews, mood rating scales, and brain imaging.
Bethesda, MarylandAges 18–70 - NCT06899490Recruiting
Acupuncture study for anxiety with tongue analysis
This trial uses machine learning to analyze tongue color and anxiety scores in people getting acupuncture for anxiety. It aims to see if tongue color can help predict treatment response.
NarbonneAges 18 years+ - NCT05651295Recruiting
Smartphone precision study to improve emotion regulation
This trial tests a precision approach delivered through a smartphone to better track and target how you manage strong emotions. It may help if you have ongoing difficulty regulating emotions day to day.
Columbus, OhioAges 18 years+ - NCT05567640Recruiting
Smart digital mental health support
This study tests a digital mental health program that uses smart technology to personalize your experience and keep you engaged. If you join, you may get a more tailored approach to improving your mental well-being.
Boston, MassachusettsAges 18 years+ - NCT07722949Recruiting
A nurse-led program for caregivers of children with autism
This study tests a culturally adapted program where nurses help caregivers build skills to support a child with autism. It aims to reduce stress and improve well-being for both the caregiver and the child.
Faisalābad, Punjab ProvinceAges 18 years+ - NCT05589337Recruiting
Baduanjin exercise program for depression and anxiety symptoms
This study tests whether practicing Baduanjin (a gentle movement/exercise) can reduce symptoms of depression and anxiety. It may help people who are able to follow instructions and communicate clearly.
Shanghai, Shanghai MunicipalityAges 18–70 - NCT07113548Recruiting
Personalized online treatment for depression
This trial tests an online program tailored to your needs for treating depression. You'll get a personalized treatment plan that you can access from your smartphone, without needing to visit a clinic.
OdenseAges 18 years+ - NCT06845488Recruiting
Using virtual reality to treat social anxiety in autism
This trial tests whether virtual reality exercises can help reduce social anxiety in adults with autism. Participants will practice social situations in a safe, computer-based environment.
Houston, TexasAges 18 years+ - NCT03859297Recruiting
Testing how rumination changes in depressed teens
This study looks at what changes in “rumination” (repetitive worrying/thinking about negative thoughts) in teens with depression, and how those changes relate to recovery. It’s for ages 14–17 who have had major depression and meet specific screening and medical rules.
Columbus, OhioAges 14–17 - NCT06523439Recruiting
Brain stimulation for depression in young people
This study tests a new type of brain stimulation called accelerated intermittent theta burst stimulation (aiTBS) in young people (ages 13-20) with depression who have not tried many treatments before. The goal is to see if this treatment can safely help reduce depression symptoms.
Austin, TexasAges 13–20 - NCT05457465RecruitingPhase 2
Cannabidiol study for anxiety and depression in bipolar disorder
This Phase 2 study tests whether cannabidiol (CBD) can reduce anxiety and depressive symptoms in people with bipolar disorder. It may help if your mood symptoms are persistent and you’re already on stable bipolar medications.
Belmont, MassachusettsAges 18–65 - NCT04870255Recruiting
Brain stimulation for depression in borderline personality disorder
This study tests a type of brain stimulation called rTMS to see if it can help improve mood in people who have both depression and borderline personality disorder. It may offer a new treatment option for those who haven't tried TMS before.
Stanford, CaliforniaAges 18–80 - NCT06906003Recruiting
Vision rehab and depression in age-related macular degeneration
This trial tests whether visual rehabilitation can help improve both vision and mood in people with advanced dry age-related macular degeneration. It aims to understand the link between vision loss and depression.
Rome, ItalyAges 55 years+ - NCT07865052Recruiting
Psychological support before complex stomach or intestinal surgery
This study tests whether a psychological program before major abdominal surgery can help reduce distress and improve recovery. Participants will receive extra mental health support to prepare for their operation.
Chicago, IllinoisAges 18 years+ - NCT07852728RecruitingPhase 2
Oxygen therapy for first responders after head injuries
This trial tests whether hyperbaric oxygen therapy (breathing pure oxygen in a pressurized chamber) can improve thinking, mood, and overall well-being in first responders who have had a traumatic brain injury and still have symptoms. If you are a first responder dealing with ongoing brain injury symptoms, this study could help you find new ways to feel better.
Boise, IdahoAges 18–75
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Common questions
- Are there clinical trials for depressive and anxiety disorders?
- Yes. Clin2 currently lists 435 recruiting depressive and anxiety disorders studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a depressive and anxiety disorders trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a depressive and anxiety disorders trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.