Clinical trials
Depressive and Anxiety Disorders clinical trials
Below are recruiting depressive and anxiety disorders clinical trials, each written for real people, not researchers. We’re tracking 456 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07065240RecruitingPhase 2
Study of SPT-300 for major depression with or without anxiety
This trial tests an experimental oral medication, SPT-300, for people with major depressive disorder, even if they also have mild anxiety. The goal is to see if it helps improve mood safely.
Chino, CaliforniaAges 18–65 - NCT07048600Recruiting
Brief trial of ACT-i for adults with chronic insomnia
This trial tests a psychological treatment called ACT-i for people with chronic insomnia (trouble sleeping for a long time). It aims to see if this online therapy can help improve sleep without drugs.
Cluj-NapocaAges 18–59 - NCT06441786Recruiting
Group therapy for depression and anxiety in autistic teens
This trial tests a group therapy that helps teenagers with autism who also have anxiety or depression learn skills to manage their thoughts and feelings. It takes place at a clinic in Stockholm.
Haninge, Stockholm CountyAges 15–18 - NCT06801925Enrolling by invitation
Voice Chatbot for Depression Screening
This trial tests a voice chatbot that uses artificial intelligence to screen for depression. It aims to see if the chatbot is effective and easy to use.
LondonAges 18–65 - NCT07721753Recruiting
Online exercise and therapy for breast cancer mood
This study tests an online program that combines fun video-game exercises with talk therapy to help breast cancer patients who feel depressed or anxious. It takes place in Malaysia and is for Chinese-speaking adults.
Xinxiang, HenanAges 18 years+ - NCT07748091Recruiting
Brain wave and inflammation markers in shock therapy for depression
This study looks at brain wave patterns and markers of inflammation in people with depression that hasn't improved with other treatments and who are receiving electroconvulsive therapy (ECT, also known as shock therapy). The goal is to understand how these markers might relate to how well ECT works.
Istanbul, BakırköyAges 18–60 - NCT07740694Recruiting
ECT study for older adults with depression
This study looks at how ECT affects brain activity and inflammation in older adults with depression. It may help researchers understand why ECT works and improve treatment.
Istanbul, BakırköyAges 55 years+ - NCT07573176RecruitingPhase 3
Seltorexant for Depression in Adults and Older Adults
This study tests a new medication called seltorexant as a standalone treatment for major depression. The trial is for adults and older adults who have depression that hasn't improved with other antidepressants or who haven't tried them yet.
Bellflower, CaliforniaAges 18–74 - NCT07552246RecruitingPhase 4
Acupuncture vs medication for depression and anxiety
This study compares acupuncture with standard medication for reducing depression, anxiety, and related sleep problems. It aims to see if acupuncture is a helpful alternative for people in China who are struggling with these conditions.
Kunshan, JiangsuAges 18–65 - NCT05671419Recruiting
Mindful self-compassion training for anxiety and depression
This study tests whether a structured “mindful self-compassion” program can reduce symptoms of anxiety disorders or depression. It’s meant to help by improving how you relate to yourself during difficult thoughts and feelings.
Washington D.C., District of ColumbiaAges 18–75 - NCT06820723RecruitingPhase 2
Testing a single dose of CYB003 for depression and anxiety
This trial tests a single dose of an investigational drug (CYB003) in people with depression and anxiety who haven't gotten enough help from their current antidepressant. You would take a psilocybin-like medication and be monitored for how it affects your mood and anxiety.
Columbus, OhioAges 21–65 - NCT05683223Recruiting
Brain and body markers to improve treatment for social anxiety
This study uses brain recordings (EEG and MRI) to understand how treatments help people with social anxiety. It also looks for signals that may predict who is most likely to benefit from treatment.
Boston, MassachusettsAges 18–50 - NCT07180537Recruiting
Health course for joint and mood conditions
This study tests an online health course that helps improve diet and self-care to support cell health and wellbeing. It is for people with certain rheumatological conditions like rheumatoid arthritis, lupus, or psoriatic arthritis, who also have mood concerns.
Iowa City, IowaAges 18–100 - NCT03953014Recruiting
Genetic study of antidepressant side effects in young people
This trial studies whether genes (using a saliva sample) can help explain why some young people feel more “disinhibited” after taking antidepressants like SSRIs. If you’ve had depression, anxiety, or OCD and have used an SSRI, your information and genetics may help improve how antidepressants are chosen and monitored.
Calgary, AlbertaAges 6–17 - NCT07703722RecruitingPhase 3
Psilocybin and therapy for depression with trauma
This trial tests psilocybin (a compound from certain mushrooms) combined with a structured therapy to see if it helps people with depression linked to trauma. It focuses on how the treatment affects the connection between the gut and brain.
Islamabad, CapitalAges 18–60 - NCT04191811Recruiting
Using brain signals to predict CBT success for mood or sleep issues
This study tests whether brain measurements can help predict who will benefit from a type of talk therapy called CBT (cognitive behavioral therapy). If you have depression, social anxiety, or insomnia, your brain “response variability” may be used to personalize or improve treatment planning.
Huddinge, Stockholm CountyAges 18 years+ - NCT04221997RecruitingPhase 4
Sertraline study for anxious children and teens
This trial tests whether sertraline (an anti-anxiety medicine) helps children and teens with generalized, separation, and/or social anxiety disorders. It also includes healthy children/teens for comparison so researchers can better understand safety and symptoms over time.
Cincinnati, OhioAges 8–17 - NCT04793828Recruiting
Self-guided online program for certain anxiety disorders
This trial tests “Velibra,” a self-guided online program to help people with anxiety disorders while they are waiting for care. It focuses on panic, social anxiety, and generalized anxiety, and may help by teaching coping skills through lessons and questionnaires.
BerlinAges 18–65 - NCT04806620Recruiting
Online app study for brain inflammation lifestyle data
This study uses a digital platform (app/website) to collect lifestyle and symptom information to better understand brain inflammation. You may qualify if you have certain conditions like Long COVID, migraines, autoimmune disease, inflammatory gut issues, mood disorders, or if you are a healthy comparison person.
Delafield, WisconsinAges 2 years+ - NCT04900064Recruiting
Self-help CBT added to primary care behavioral health
This trial studies whether adding a Swedish self-help version of “CBT” (a structured talking-therapy approach) improves care for adults getting behavioral health support in primary care. It may help people who want support for mental health without needing fully guided therapy sessions.
Varberg, Halland CountyAges 18 years+ - NCT00018057RecruitingPhase 2
Brain study of pediatric anxiety disorders
This study looks at how the brain works in children and adults with anxiety disorders. It uses brain scans (fMRI) and other safe tests to understand anxiety better.
Bethesda, MarylandAges 8–65 - NCT05117255Recruiting
Online therapy study for anxiety in residential alcohol treatment
This study tests an internet-based, interactive version of cognitive behavioral therapy (CBT) for anxiety symptoms. It’s designed for people getting mainly alcohol-focused treatment in a residential program, to see if the online approach works and is feasible for you.
Minneapolis, MinnesotaAges 18–65 - NCT05232032RecruitingPhase 2
Brain scan and medication study for avoiding versus approaching
This Phase 2 study looks at how a medication affects brain activity and real-life mood or anxiety behaviors. It includes people with major depression or several anxiety disorders and also healthy volunteers, using questionnaires, a smartphone, and brain imaging.
Belmont, MassachusettsAges 18–45 - NCT05466851Recruiting
Study testing anxiety and depression biology and therapy markers
This study looks at “biopsychosocial markers” (biological, psychological, and social signs) in people with major depression and/or anxiety. It aims to understand what changes with treatment and how those changes connect to symptoms like anxiety and depression.
New York, New YorkAges 18–65
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Common questions
- Are there clinical trials for depressive and anxiety disorders?
- Yes. Clin2 currently lists 456 recruiting depressive and anxiety disorders studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a depressive and anxiety disorders trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a depressive and anxiety disorders trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.