Clinical trials
Digestive Cancer clinical trials
Below are recruiting digestive cancer clinical trials, each written for real people, not researchers. We’re tracking 60 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT03800693RecruitingPhase 2
Shorter vs longer oxaliplatin infusions for gut cancer
This Phase 2 study compares giving oxaliplatin by IV for 2 hours versus 6 hours, along with the standard FOLFOX6 chemotherapy. It aims to see if the shorter infusion works as well and is manageable for people with gastrointestinal cancers.
Atlanta, GeorgiaAges 18 years+ - NCT06479070Recruiting
Using ctDNA to guide radiotherapy for head and neck cancer
This study looks at whether measuring a DNA fragment in the blood (called ctDNA) can help predict how well radiotherapy works for head and neck cancer. It may help doctors better tailor treatment for patients with stage III or IV disease.
Caen, CaenAges 18 years+ - NCT05956847Recruiting
Studying DNA fragments in stomach cancer tissue
This trial looks at tiny pieces of DNA found outside cells in stomach tissue to better understand how gastric (stomach) cancer starts and progresses. It may help future patients by improving how doctors study stomach cancer from biopsy and surgical samples.
Xi'an, ShaanxiAges 18–80 - NCT06104241RecruitingEarly Phase 1
Cell therapy for advanced digestive cancers
This trial tests a new cell therapy called BGT007 for people with advanced cancers of the digestive system (esophagus, stomach, pancreas, or colon) that have not responded to standard treatments. The therapy uses your own immune cells, modified to target a protein on your cancer cells.
Xuzhou, JangSuAges 18–70 - NCT05624099RecruitingPhase 2
Camrelizumab plus chemoradiotherapy for advanced esophageal cancer
This study tests whether adding camrelizumab (an immune treatment) to standard chemoradiotherapy can control advanced esophageal squamous cell cancer. It is meant for people who have not had any prior whole-course cancer medicines for this cancer stage.
FuzhouAges 18–75 - NCT07222800RecruitingPhase 3
Testing a new drug plus chemo for stage 4 colorectal cancer
This study tests a new experimental drug (PF-08634404) combined with standard chemotherapy for people with stage 4 colorectal cancer who have not yet been treated for their advanced disease. The goal is to see if the combination helps shrink or slow the growth of tumors.
Chandler, ArizonaAges 18 years+ - NCT06353854Recruiting
Study of biomarkers in MSI-high colorectal cancer patients on immunotherapy
This trial is studying people with a specific type of advanced colorectal cancer (MSI-high/dMMR) who are starting immunotherapy with pembrolizumab. The goal is to find out which markers in the tumor might predict whether the treatment works well.
BayonneAges 18 years+ - NCT07283653Recruiting
Using DIGEST™ to measure swallowing problems in cancer patients
This trial is testing how well a tool called DIGEST™ works to measure swallowing difficulties (dysphagia) in cancer patients who have a special x-ray called a Modified Barium Swallow. The goal is to help doctors better understand and treat swallowing problems.
Houston, TexasAges 18 years+ - NCT07456852RecruitingPhase 1/Phase 2
Can vasodilators help with chemo side effects in GI cancer?
This trial tests two drugs (isosorbide mononitrate and diltiazem) to see if they can prevent blood vessel damage caused by chemotherapy drugs like 5-FU or capecitabine in people with gastrointestinal cancers.
Rochester, MinnesotaAges 18 years+ - NCT01109420Recruiting
Family study of non-medullary thyroid cancer and genetics
This study looks at families affected by non-medullary thyroid cancer to understand patterns and possible genetic risk. You may be able to join even if you personally do not have the cancer, as long as you have the right family history and can complete a questionnaire.
Bethesda, MarylandAges 7–90 - NCT06817161RecruitingPhase 3
Nerve stimulation for quality of life during ovarian cancer treatment
This trial tests if a gentle nerve stimulation device on the ear can improve quality of life for people with ovarian cancer who are starting their first chemotherapy. It may help manage symptoms like fatigue or feeling sick.
CaenAges 18 years+ - NCT04666727Recruiting
Diet and gut microbiome study during screening colonoscopy
This study looks at how a person’s diet (vegetarian vs. omnivorous) affects the germs in the gut and related stool and tissue samples. You may be able to join if you’re getting a screening colonoscopy and meet lifestyle and medication requirements.
Houston, TexasAges 45 years+ - NCT00001160Recruiting
Study of thyroid lumps and thyroid cancer
This study looks at people who have or may have thyroid nodules (lumps in the thyroid gland in your neck) or thyroid cancer, as well as family members who may have inherited a higher risk. It aims to better understand and diagnose these thyroid problems.
Bethesda, MarylandAges 6 months–98 years - NCT06207656RecruitingPhase 2
Targeted therapy for BRAF V600E mutated colorectal cancer
This trial tests if combining three targeted drugs (cetuximab, encorafenib, and binimetinib) before surgery can shrink or control cancer in people with a specific BRAF V600E mutation and a stable (MSS) tumor. It focuses on colorectal cancer that is either already able to be removed or could become removable with treatment.
MadridAges 18 years+ - NCT07401303Recruiting
Studying a new way to reduce risks during early stomach cancer surgery
This trial tests a technique called full-time RDI during ESD (a minimally invasive procedure to remove early stomach cancer). The goal is to see if it can lower the chance of serious side effects and shorten the procedure time. If you are scheduled for this surgery and meet the health requirements, you may be able to join.
Xi'an, ShaanxiAges 18–75 - NCT07347158Enrolling by invitation
Health education for ostomy patients
This study teaches people with an ostomy (a surgical opening for waste) about their health to improve their quality of life and reduce anxiety or depression. If you are an adult with a permanent or long-term ostomy and live in the Santiago or Barbanza area, you may be able to join.
Santiago de Compostela, A CoruñaAges 18 years+ - NCT04927416RecruitingPhase 2
Ga-DOTATATE PET/CT scan in metastatic thyroid cancer
This study tests whether a specific special scan (68-Gallium DOTATATE PET/CT) can help doctors better see where thyroid cancer has spread. It focuses on certain types of thyroid cancer and compares how well the scan images metastases.
Bethesda, MarylandAges 18–98 - NCT05706779RecruitingPhase 2
Encorafenib plus cetuximab before surgery for BRAF-mutated colon cancer
This trial tests whether giving encorafenib and cetuximab before surgery can shrink or control BRAF-mutated colon or upper rectal cancer and make surgery more effective. It also checks whether this approach is safe and helps patients do better overall.
ParisAges 18 years+ - NCT05398783Recruiting
Study of how metabolism and body composition change over time
This natural history study follows people to understand how metabolism and body composition vary in health and disease. It may help researchers better measure metabolic changes and understand who is at risk as health and treatments change.
Bethesda, MarylandAges 2–99 - NCT07124858Recruiting
Fruquintinib for advanced colorectal cancer
This study tracks how well fruquintinib works for people with advanced colorectal cancer that has spread. It aims to find factors that predict better outcomes, using blood and tumor samples.
Poitiers, FranceAges 18 years+ - NCT07594626RecruitingPhase 1/Phase 2
BMS-986504 and Pemetrexed for Advanced Tumors With MTAP Loss
This trial tests a new drug (BMS-986504) combined with an existing chemotherapy (pemetrexed) for advanced solid cancers that have a specific genetic change called MTAP deletion. The trial aims to see if this combination can slow or stop tumor growth in patients whose cancer has progressed despite prior treatment.
Chicago, IllinoisAges 18 years+ - NCT03841617RecruitingPhase 2
Measure radiation in thyroid cancer using a special PET-CT scan
This trial tests how much radiation a specialized whole-body PET/CT scan delivers in patients with differentiated thyroid cancer. It may help doctors better plan treatment for cancer that persists, returns, or has spread—especially when radioactive iodine (RAI) may or may not work.
Bethesda, MarylandAges 18–90 - NCT04221893Recruiting
Radiation therapy for metastatic gastrointestinal cancers
This trial tests whether adding radiation therapy to your current immunotherapy can help control cancer that has spread in the digestive system. It aims to improve symptoms and possibly slow the cancer's growth.
San Francisco, CaliforniaAges 18 years+ - NCT07769892Recruiting
Blood and stool test for digestive tract cancer screening
This study is testing a new way to screen for cancers of the digestive tract using a simple blood and stool test. It is for people who are already scheduled to have a digestive tract endoscopy, and it may help find cancers earlier without extra invasive procedures.
Zhaoqing, GuangdongAges 45–74
Hear when a new Digestive Cancer trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.
Common questions
- Are there clinical trials for digestive cancer?
- Yes. Clin2 currently lists 60 recruiting digestive cancer studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a digestive cancer trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a digestive cancer trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.