Clinical trials
Down Syndrome clinical trials
Below are recruiting down syndrome clinical trials, each written for real people, not researchers. We’re tracking 3,196 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06821802Recruiting
Protein supplement for low sodium from SIAD
This trial tests if a protein supplement can help patients with low sodium caused by a condition called SIAD. If you have SIAD and low sodium, you may be able to join.
BaselAges 18 years+ - NCT06825390Recruiting
Ear stimulation and brain imaging for chronic low back pain
This study tests if a non-invasive ear stimulation technique can change brain activity linked to chronic low back pain. You would have a brain scan before and after the treatment to see how your brain responds.
Pittsburgh, PennsylvaniaAges 18 years+ - NCT06825520Recruiting
Studying urges before tics during habit reversal training
This study tests whether a therapy called 'habit reversal training' can help reduce the strong urges that happen before tics. It is for children and teens (ages 8–17) who have at least 3 tics and feel a warning urge before each tic.
Salt Lake City, UtahAges 8–17 - NCT06828042RecruitingPhase 1/Phase 2
CAR-γδT cells for refractory autoimmune diseases
This trial tests a new type of immune cell therapy (CAR-γδT cells) that targets a protein called CD19 on your own B cells. It is for people with certain autoimmune diseases that have not gotten better with standard treatments. The goal is to see if this therapy can safely control the disease.
BeijingAges 18–80 - NCT06834061Recruiting
Using ultrasound to diagnose and manage carpal tunnel syndrome
This trial tests if ultrasound can help doctors better diagnose and track carpal tunnel syndrome (a condition where a nerve in your wrist gets squeezed). It may lead to better treatment and follow-up without extra tests.
Kafr ash Shaykh, KafrelsheikhAges 18 years+ - NCT06836128RecruitingPhase 3
N-Acetyl Cysteine and Metformin for PCOS
This trial tests whether adding N-acetyl cysteine (NAC) to metformin helps women with PCOS more than metformin alone. It might be a good fit if you have PCOS, are between 20 and 45, and don't have other health issues like diabetes or thyroid problems.
CairoAges 20–45 - NCT06839456RecruitingPhase 1/Phase 2
Stem cell addback to prevent infections after transplant
This trial tests whether adding back certain immune cells after a stem cell transplant can help prevent serious viral or fungal infections. It's for children and young adults up to age 25 who need a transplant for a blood cancer or other curable disease.
Philadelphia, PennsylvaniaAges 1 month–25 years - NCT06840496RecruitingPhase 3
Study of oral NA-921 vs placebo for girls and women with Rett syndrome
This trial tests an oral medication called NA-921 in females with Rett syndrome to see if it works better than a placebo. It may be an option for those who have a confirmed MECP2 gene mutation and stable seizure patterns.
Phoenix, ArizonaAges 5–20 - NCT06842524RecruitingPhase 2
Dihydroartemisinin for PCOS: A Phase 2 Trial
This trial tests if dihydroartemisinin (a medicine derived from a plant) can help women with PCOS. It may improve hormone balance and menstrual cycles.
Xiamen, FujianAges 18–40 - NCT06847867RecruitingPhase 2
Testing momelotinib for low-risk myelodysplastic syndrome
This study tests a new drug, momelotinib, for people with a low-risk form of myelodysplastic syndrome (MDS) who need red blood cell transfusions and have already tried one other treatment (like ESAs or luspatercept). The goal is to see if momelotinib can help reduce transfusion needs.
Goodyear, ArizonaAges 18 years+ - NCT06849908RecruitingPhase 2
Baricitinib for treating intestinal Behçet's disease
This trial tests baricitinib, an oral medication, for people with intestinal Behçet's disease that hasn't improved with standard treatments. It aims to see if baricitinib can reduce symptoms and help heal gut ulcers.
Beijing, Beijing MunicipalityAges 18–65 - NCT06851338Recruiting
Inspire therapy study for teens with Down syndrome and sleep apnea
This study tests a device called Inspire that stimulates the airway during sleep to treat obstructive sleep apnea in teenagers with Down syndrome who cannot use a CPAP machine or had a tonsillectomy that did not work well.
Phoenix, ArizonaAges 13–18 - NCT06852365RecruitingPhase 2
Birth control pill and resistant starch for PCOS
This trial tests whether adding a type of fiber (resistant starch) to a common birth control pill can improve health in women with PCOS. It aims to see if this combination helps with weight, hormones, and metabolism.
Philadelphia, PennsylvaniaAges 18–40 - NCT06863740Recruiting
Cannabis for Restless Legs Syndrome
This study tests whether cannabis can help people with Restless Legs Syndrome that has not improved with standard treatments. If you have RLS and other treatments haven't worked well, you may be able to join.
Toronto, OntarioAges 25 years+ - NCT06866925Recruiting
Brain stimulation for depression with catatonia in Down syndrome
This study tests whether a gentle brain stimulation treatment called tDCS can help people with Down syndrome who are also experiencing severe depression with symptoms like being very still or not speaking. The goal is to see if this safe, non-invasive treatment can improve mood and movement.
Lyon, Auvergne-Rhône-AlpesAges 18 years+ - NCT06867159Recruiting
Muscle relaxation techniques for IT band syndrome
This study compares two gentle muscle-relaxing techniques to treat iliotibial (IT) band syndrome, a common cause of outer knee pain. It may help if you have had outer knee pain for more than 3 months and are between 19 and 45 years old.
Rawalpindi, Punjab ProvinceAges 19–45 - NCT06874855RecruitingPhase 4
Study of sleep medication for delayed sleep phase syndrome
This trial tests whether a sleep medication called lemborexant can help people with delayed sleep phase syndrome fall asleep earlier. It may improve sleep timing and reduce the impact on daily life.
San Francisco, CaliforniaAges 18 years+ - NCT06875102Recruiting
Treating fatigue in Sjögren's syndrome with auricular stimulation
This trial tests three non-medication strategies for fatigue in Sjögren's syndrome, including a type of ear stimulation. It aims to find a better way to help people who have had fatigue for at least 6 months with no clear cause.
Saint-EtienneAges 18 years+ - NCT06875804Recruiting
Compressive release for knee cap tracking in knee pain
This trial tests a hands-on therapy called compressive myofascial release for the muscle on the outside of your thigh. It aims to see if it helps with kneecap tracking problems that cause pain during daily activities.
Lahore, Punjab ProvinceAges 20–40 - NCT06877715Recruiting
Sensory and autism traits in children with Prader-Willi syndrome
This study looks at autism-like symptoms and sensory profiles in children with Prader-Willi syndrome (PWS). It aims to better understand these traits to improve care and support.
ToulouseAges 3–16 - NCT06880679Recruiting
Ultrasound for acute chest syndrome in sickle cell disease
This study uses a bedside ultrasound to check for acute chest syndrome in children and young adults with sickle cell disease who are in the hospital. The goal is to see if this simple scan can help diagnose the condition early.
Indianapolis, IndianaAges Up to 25 years - NCT06881368Recruiting
Understanding Susac syndrome in adults
This study looks at Susac syndrome, a rare condition that affects the brain, ears, and eyes. If you have hearing loss, vision problems, or confusion, researchers want to understand what causes it and how it affects people like you.
ParisAges 18 years+ - NCT06882603Recruiting
Steroid injections and nerve hydrodissection for carpal tunnel
This trial compares two treatments for carpal tunnel syndrome: a corticosteroid injection (which reduces swelling) and a newer technique called nerve hydrodissection (which uses fluid to free the nerve). The goal is to see which works better for relieving pain and improving hand function.
Kırşehir, City CentreAges 18–65 - NCT06884852Recruiting
Preventing pain after mastectomy: nerve block vs. epidural
This study compares two methods to prevent long-term pain after breast cancer surgery: a nerve block using ultrasound guidance or an epidural. The goal is to see which helps women feel less pain months after their mastectomy.
CairoAges 18–65
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Common questions
- Are there clinical trials for down syndrome?
- Yes. Clin2 currently lists 3,196 recruiting down syndrome studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a down syndrome trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a down syndrome trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.