Clinical trials
Down Syndrome clinical trials
Below are recruiting down syndrome clinical trials, each written for real people, not researchers. We’re tracking 3,057 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06758518Enrolling by invitation
Carpal tunnel syndrome in medical students: stress and depression
This study looks at how stress and depression might affect carpal tunnel syndrome in medical students. It could help us understand if emotional health plays a role in this common wrist condition.
Ioannina, EpirusAges Any age - NCT06757491Recruiting
Low frequency brain stimulation for diarrhea-predominant IBS pain
This trial tests if a type of brain stimulation called low-frequency repetitive transcranial magnetic stimulation (lf-rTMS) can reduce belly pain in people with irritable bowel syndrome that causes diarrhea (IBS-D). It is a non-invasive treatment that uses magnetic pulses to target areas of the brain involved in pain perception.
Suzhou, JiangsuAges 18–75 - NCT06758193Enrolling by invitation
Testing a hand symptom scale for carpal tunnel syndrome
This study tests whether a hand-related questionnaire called the MAP-Hand Scale is a reliable and accurate tool for people with carpal tunnel syndrome. If you have mild to moderate carpal tunnel syndrome in one hand, your answers could help improve how doctors measure symptoms.
Kırşehir, MerkezAges 18–65 - NCT06142656RecruitingPhase 2/Phase 3
Vildagliptin vs Metformin for PCOS
This trial compares two medicines, vildagliptin and metformin, to see which works better for women with Polycystic Ovary Syndrome (PCOS). The goal is to find a safe and effective treatment that may help manage PCOS symptoms.
GizaAges 18–50 - NCT06747949RecruitingPhase 3
Long term extension study of dazodalibep for Sjogren's syndrome
This study gives continued access to the study drug dazodalibep for people with Sjogren's syndrome who completed a prior phase 3 study. The goal is to see how safe and effective the medication is over a longer period.
Avondale, ArizonaAges 18 years+ - NCT06739434Enrolling by invitation
Gene Therapy for Girls with Rett Syndrome
This trial tests a new gene therapy called GCB-002 for girls with Rett syndrome. The treatment aims to help with symptoms by targeting the genetic cause.
Shanghai, Shanghai MunicipalityAges 2–10 - NCT06156176Recruiting
Exercise for COVID-19 fatigue: a feasibility study
This study tests whether a personalized exercise program can help reduce fatigue after a COVID-19 infection. You'll work with a coach over video calls to see if gentle activity can improve your energy levels.
London, OntarioAges 18 years+ - NCT06730126RecruitingPhase 2
Soquelitinib for ALPS-FAS-related swelling and low blood counts
This trial tests an investigational drug called soquelitinib to see if it can shrink enlarged lymph nodes and improve low blood cell counts in people with ALPS-FAS. It may offer a new treatment option for those who have active symptoms.
Bethesda, MarylandAges 16–120 - NCT06737718Recruiting
Eye tracking study for children with Angelman syndrome
This trial uses eye tracking to understand how children with Angelman syndrome perceive social cues. Participation helps researchers learn more about social perception for future treatments.
ParisAges 3–17 - NCT06736665Recruiting
Comparing two ways to treat hardened calcium in heart arteries
This trial compares two techniques (orbital atherectomy and intravascular lithotripsy) to break up tough calcium deposits in the heart's arteries that can block blood flow. If you have a calcified nodule and are having a non-emergency procedure to open a blocked artery, this study may help guide which method works best.
Alicante, AlicanteAges 18 years+ - NCT06726785Recruiting
Gene changes in nasal cells of RLS patients on long-term dopamine agonist
This study looks at changes in a gene (DRD2) in nasal cells of people with Restless Legs Syndrome who are taking a dopamine agonist medication for a long time. It aims to understand how this gene might be involved in RLS.
San Francisco, CaliforniaAges 18–60 - NCT06723106Enrolling by invitationPhase 1
Long-term safety study of RAY121 for immune conditions
This study is for people who already took RAY121 in a previous trial and did well. It tests whether continuing the treatment is safe and effective over a longer period. The goal is to manage chronic immune conditions.
Camperdown, New South WalesAges 18–85 - NCT03401047RecruitingEarly Phase 1
Estradiol patch study for hormone signaling in PCOS
This early-stage study tests whether adding an estrogen skin patch (estradiol) can change how your body releases key reproductive hormones in adults with PCOS. It may help researchers better understand PCOS-related hormone control and signaling.
Charlottesville, VirginiaAges 18–30 - NCT06717477Enrolling by invitation
Improving care for carpal tunnel syndrome patients
This trial tests a new streamlined care pathway for patients with carpal tunnel syndrome. It aims to make appointments and treatments easier and faster.
Vancouver, British ColumbiaAges 18 years+ - NCT06716411Recruiting
Acupuncture for Gulf War Illness relief
This study tests whether acupuncture can help relieve Gulf War Illness symptoms like fatigue, mood or thinking problems, and muscle or joint pain. You may be able to join if you were deployed to the Gulf region and have had these symptoms for more than 6 months.
Berkeley, CaliforniaAges 18 years+ - NCT06712810RecruitingPhase 1
Q702 for blood cancers and histiocytic disorders
This study tests an experimental pill called Q702 for people with certain blood cancers and related disorders (like histiocytoses, myelofibrosis, and lymphomas) that have not responded to standard treatments. It aims to see if Q702 is safe and effective.
Scottsdale, ArizonaAges 18 years+ - NCT06705816Recruiting
Cognitive function in Rett syndrome during trofinetide treatment
This study looks at how trofinetide (a medicine for Rett syndrome) affects thinking and memory in people with Rett syndrome. It will follow participants who are starting this treatment through a specific clinic.
Minneapolis, MinnesotaAges 18–99 - NCT06715735Recruiting
A health coaching program for metabolic syndrome with kidney disease
This trial tests if a personalized health coaching program can help people with metabolic syndrome and chronic kidney disease make lasting lifestyle changes. If you have both conditions and are not yet on dialysis, this program may help you manage your health.
Chengdu, SichuanAges 18 years+ - NCT06706102RecruitingPhase 4
Study of Tiny Blood Particles During CAR-T Therapy
This study is for people getting CAR-T cell therapy, a type of cancer treatment that uses your own immune cells. Researchers want to understand a rare side effect called neurotoxicity by looking at tiny particles in your blood called extracellular vesicles.
Saint-EtienneAges 18 years+ - NCT05319132Recruiting
Test a lab treatment for ROSAH syndrome using blood cells
This trial studies DF-003 in lab tests using blood immune cells taken from people with ROSAH syndrome. It aims to see whether the treatment works in lab “ex vivo” tests and could guide future options.
Lyon, Auvergne-Rhône-AlpesAges 18 years+ - NCT06696261RecruitingPhase 3
Lianxiaxiaopi granules for post-meal fullness
This study tests a Chinese herbal granule (Lianxiaxiaopi) for people with postprandial distress syndrome, a condition where you feel full too soon or uncomfortably full after eating. The goal is to see if it helps reduce these symptoms.
Beijing, Beijing MunicipalityAges 18–65 - NCT06697236Recruiting
Socioeconomic status and recovery after intensive care
This study looks at how your financial and social situation might affect your recovery after a serious ICU illness. You and one close family member or friend will fill out questionnaires to help doctors better understand long-term challenges for ICU survivors.
DijonAges 18 years+ - NCT06694363Recruiting
New test to guide treatment for APDS immune disorder
This study uses a new blood test to find and monitor people with APDS, a rare immune disease, who may be helped by the drug leniolisib. It aims to improve how doctors screen and track treatment response.
BordeauxAges 12 years+ - NCT06692894Recruiting
Inflammation and Heart Risk in Myelodysplastic Syndromes
This study looks at whether certain signs of inflammation in the blood can help predict heart problems in people with myelodysplastic syndromes (MDS). If you have MDS and are generally well enough to participate, this trial may help doctors better understand and manage your risk of heart disease.
Burlington, VermontAges 18 years+
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Common questions
- Are there clinical trials for down syndrome?
- Yes. Clin2 currently lists 3,057 recruiting down syndrome studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a down syndrome trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a down syndrome trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.