Clinical trials
Down Syndrome clinical trials
Below are recruiting down syndrome clinical trials, each written for real people, not researchers. We’re tracking 3,057 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06683521Recruiting
Understanding the immune system in FPIES
This study looks at how the immune system works in people with Food Protein-Induced Enterocolitis Syndrome (FPIES). It aims to learn more about this condition to improve future diagnosis and treatment.
New York, New YorkAges 1–60 - NCT06688838Enrolling by invitation
JAK inhibitor for Blau syndrome
This trial tests a new oral drug that blocks inflammation in people with Blau syndrome, a rare genetic condition causing joint, eye, and skin problems. The goal is to see if the drug can reduce symptoms and improve quality of life.
Wuhan, HubeiAges Any age - NCT06635213Recruiting
Desensitisation and pain education for carpal tunnel syndrome
This study tests whether desensitisation therapy and pain neuroscience education help people with carpal tunnel syndrome who have a type of pain called 'nociplastic' (pain without clear tissue damage). It aims to reduce pain and improve function.
KütahyaAges 18–65 - NCT06684379RecruitingPhase 1/Phase 2
Two Doses of PRS CK STORM for Severe Viral Pneumonia
This study tests a new drug called PRS CK STORM to see if it can safely calm the body's overactive immune response (cytokine storm) in people with severe pneumonia from COVID-19, flu, or RSV who need oxygen. It aims to reduce inflammation and improve recovery.
Alcalá de Henares, MadridAges 18 years+ - NCT06679855RecruitingPhase 3
Milrinone to prevent heart problems after PDA closure
This trial tests if giving milrinone before surgery to close a common heart vessel (PDA) can prevent heart issues in premature babies. It may help very premature infants who need surgery for a large PDA.
Birmingham, AlabamaAges Up to 3 months - NCT06669949Recruiting
Studying the natural history of SPLIS disease
This study collects health information from people with SPLIS to better understand the condition over time. It may include your siblings if they also have SPLIS, and data from patients who have passed away.
San Francisco, CaliforniaAges Any age - NCT06679790Recruiting
Understanding changes in Tourette Syndrome over time
This study tracks how tics and related symptoms change over time in people with Tourette Syndrome. It aims to better understand the condition and could help develop better treatments.
Minneapolis, MinnesotaAges 12–17 - NCT06670222RecruitingPhase 1
Arsenic for low-risk MDS
This study tests an oral form of arsenic in people with low-risk myelodysplastic syndromes (MDS) who need regular red blood cell transfusions and haven't gotten enough benefit from standard treatments. It aims to see if this drug can help reduce transfusion needs.
NiceAges 18 years+ - NCT06681363Recruiting
Leukemia and MDS biobank study at Nantes Hospital
This trial creates a biobank of blood or bone marrow samples from patients with acute myeloid leukemia (AML), acute lymphoblastic leukemia (ALL), or high-risk myelodysplastic syndrome (MDS). It aims to collect samples for future research, which may help develop better treatments.
NantesAges 18 years+ - NCT05643209Recruiting
Mapping and ablation to treat abnormal heart electrical signals
This study uses detailed 3D heart mapping to find where abnormal electrical activity starts in Brugada syndrome and then performs ablation (a targeted scar or block). It’s mainly for adults who have had concerning symptoms and already have an implanted defibrillator (ICD).
Cotignola, RavennaAges 18 years+ - NCT06660901Recruiting
Study on cannabis use and vomiting in emergency rooms
This study looks at patients who come to the ER with belly pain or vomiting and uses cannabis, to better understand a condition called cannabinoid hyperemesis syndrome (severe nausea and vomiting caused by long-term cannabis use). If you're eligible, you'll answer a few questions to help doctors learn more.
AngersAges 18–65 - NCT06660329Enrolling by invitationPhase 4
Tofacitinib for hard-to-treat Blau syndrome
This study tests if the drug tofacitinib (a JAK inhibitor) can help people with Blau syndrome whose symptoms did not improve with other treatments. Blau syndrome is a rare genetic condition that causes inflammation in the skin, joints, eyes, and other organs.
BeijingAges birth–18 years - NCT06668922Recruiting
Diet and irritable bowel syndrome study
This study compares how people with and without irritable bowel syndrome (IBS) react to different foods. It may help find which foods trigger symptoms and which are safe to eat.
Los Angeles, CaliforniaAges 18–75 - NCT06560294Recruiting
Glue injection vs watchful waiting for pelvic congestion syndrome
This trial compares a new glue injection treatment (embolization) with no active treatment for pelvic congestion syndrome. It aims to see if the glue procedure reduces pelvic pain and varicose veins better than just monitoring symptoms.
Tanta, ElGharbiaAges 30–50 - NCT06649461Enrolling by invitation
Ozone therapy and splint for carpal tunnel syndrome
This trial tests if adding ozone therapy to a wrist splint helps relieve mild-to-moderate carpal tunnel syndrome symptoms like numbness, tingling, and pain. It compares the combination to a splint alone.
KocaeliAges 18–65 - NCT06655844Recruiting
Sana Device for chronic pain from Lyme disease
This study tests the Sana device—a special light and sound tool—to see if it can help reduce chronic nerve pain in people with Post-Treatment Lyme Disease Syndrome. You may be able to join if you have ongoing nerve pain after Lyme treatment and meet a few basic health and medication rules.
New York, New YorkAges 18 years+ - NCT05740761Recruiting
Gene editing for children with Rett syndrome
This trial tests a gene-editing approach for Rett syndrome in children who have a confirmed MECP2 gene mutation. It may help by targeting specific “hotspot” genetic changes that cause the condition.
Siena, SienaAges 6 months+ - NCT06635629RecruitingPhase 2
Desmopressin test for ACTH-dependent Cushing syndrome
This trial studies how well a desmopressin stimulation test works to diagnose ACTH-dependent Cushing syndrome. It compares results from people with possible or recurrent Cushing syndrome and healthy volunteers.
Bethesda, MarylandAges 18–70 - NCT06641414RecruitingPhase 3
Lisaftoclax with azacytidine for higher-risk myelodysplastic syndrome
This trial tests a new drug called lisaftoclax combined with a standard treatment, azacytidine, for people newly diagnosed with higher-risk myelodysplastic syndrome (MDS). The goal is to see if the combination helps control the disease better than what's currently available.
Birmingham, AlabamaAges 18 years+ - NCT06630650Recruiting
Study of Congenital Myasthenic Syndrome (CMS) Over Time
This study follows people with congenital myasthenic syndrome (CMS) over time to learn more about how the condition changes and to find better ways to measure symptoms. You will not receive any treatment, but your participation helps researchers understand CMS better.
Bethesda, MarylandAges 6 months–99 years - NCT05432466RecruitingPhase 3
Celiprolol vs placebo for vascular Ehlers-Danlos heart vessel fragility
This Phase 3 study compares celiprolol (a blood vessel–related medicine) versus placebo to see which better reduces vascular risks in people with vascular Ehlers-Danlos syndrome. It requires confirmed COL3A1 genetic findings and specific imaging before starting.
Culver City, CaliforniaAges 15–64 - NCT06614270Recruiting
CAR-NK cell therapy for severe autoimmune diseases
This trial tests a new type of immune cell therapy using modified natural killer cells (CAR-NK) that target a protein called CD19 and produce helpful signals (IL-10 and IL-15). It is for people with certain autoimmune diseases that have not improved with standard treatments or have come back after getting better.
Hangzhou, ZhejiangAges 18–65 - NCT06616636RecruitingPhase 1
Rezatapopt and azacitidine for AML or MDS with a specific TP53 mutation
This trial tests a new drug, rezatapopt, combined with azacitidine for people with acute myeloid leukemia (AML) or myelodysplastic syndrome (MDS) that has come back or not responded to treatment. It is only for people whose cancer cells have a specific change in a gene called TP53 (the Y220C mutation). The goal is to see if this combination can help control the disease.
Tampa, FloridaAges 18 years+ - NCT06612242Recruiting
Early vs. late tracheostomy in Guillain-Barre patients
This trial looks at whether having a tracheostomy (a breathing tube placed through the neck) earlier or later helps people with Guillain-Barre syndrome who need a breathing machine. It reviews past cases to see which timing leads to better recovery.
Kfar SabaAges 18 years+
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Common questions
- Are there clinical trials for down syndrome?
- Yes. Clin2 currently lists 3,057 recruiting down syndrome studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a down syndrome trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a down syndrome trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.