Clinical trials
Esophageal Adenocarcinoma clinical trials
Below are recruiting esophageal adenocarcinoma clinical trials, each written for real people, not researchers. We’re tracking 112 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07432295RecruitingPhase 2
Givastomig plus nivolumab and chemo for advanced stomach cancer
This trial tests a new drug, givastomig, combined with standard immunotherapy (nivolumab) and chemotherapy for people with advanced stomach, gastroesophageal junction, or esophageal cancer. It is for people whose tumors have certain markers (CLDN18.2 and PD-L1) and who have not had treatment for advanced disease.
Goodyear, ArizonaAges 18 years+ - NCT07218003Enrolling by invitationPhase 1
Study of RNDO-564 alone or with pembrolizumab for bladder cancer
This trial tests an experimental drug, RNDO-564, either by itself or combined with another drug (pembrolizumab), for people with advanced bladder cancer or other solid tumors that have stopped responding to standard treatments. The goal is to see if it can shrink tumors or slow cancer growth.
San Francisco, CaliforniaAges 18 years+ - NCT06687603Recruiting
Detecting Barrett's esophagus in people without heartburn
This study aims to screen for Barrett's esophagus in people who are getting a routine colonoscopy but do not have chronic heartburn. It uses a simple, non-invasive cell collection device (EsoCheck) to see if you might have Barrett's esophagus, which can increase the risk of esophageal cancer.
Aurora, ColoradoAges 50 years+ - NCT06523374Recruiting
Studying quality of life and cancer risk in Barrett's esophagus
This study looks at how Barrett's esophagus affects your quality of life and fear of cancer. It uses new tests to better predict who might develop esophageal cancer, so you can get the right care sooner.
Edegem, AntwerpenAges 18 years+ - NCT05965999Recruiting
Registry study for esophageal precancer screening
This study collects information from people who are already being screened for Barrett's esophagus or esophageal cancer using the EsoCheck and EsoGuard tests. It helps doctors learn more about how well these tests work in real life.
Lake Forest, CaliforniaAges Any age - NCT05753748Recruiting
Surveillance vs. endoscopic treatment for Barrett's esophagus with low-grade dysplasia
This study compares two approaches for people with Barrett's esophagus and low-grade dysplasia: regular surveillance (monitoring with endoscopies) versus endoscopic treatment to remove the abnormal cells. It aims to see which approach is better at preventing progression to more serious conditions.
Birmingham, AlabamaAges 18–89 - NCT05530343Recruiting
Two ways to sample tissue during Barrett’s follow-up
This study compares two tissue-collection methods during an endoscopy for Barrett’s esophagus to see which one detects concerning changes better. Your results could help improve how doctors check Barrett’s over time.
Gilbert, ArizonaAges 18–89 - NCT05276791Recruiting
Compare two endoscopy removal methods for Barrett’s lesions
This study compares two ways doctors remove abnormal tissue in the esophagus during endoscopy: EMR versus ESD. It may help improve how safely and completely these lesions are removed, while also comparing outcomes between the two methods.
AmsterdamAges 18 years+ - NCT03539822RecruitingPhase 1/Phase 2
Cabozantinib and immunotherapy for advanced stomach or bowel cancers
This early-phase study tests a combination of anti-cancer pills and immune-based treatment for people with advanced stomach, esophagus, colorectal, or liver cancer. It aims to shrink tumors and see how safe the treatment is, including whether biopsy testing can help guide future care.
Westwood, KansasAges 18 years+ - NCT00587314Enrolling by invitation
Testing ablation treatment for Barrett’s with precancer changes
This trial studies whether an “ablation” procedure (destroying abnormal esophagus lining) works well for people with Barrett’s esophagus that has high-grade precancer changes or very early cancer. It may help find safer or more effective ways to prevent the condition from worsening.
Rochester, MinnesotaAges 18–90 - NCT05517811Recruiting
Blood clotting tests before and after surgery for cancer
This study looks at how cancer and surgery affect blood clotting. It may help doctors understand and prevent blood clots in patients having surgery for certain cancers.
Aurora, ColoradoAges 18–99 - NCT02427269Enrolling by invitation
Blood and tissue sample study for esophagus conditions
This study collects blood and biopsy tissue from people who are having an upper endoscopy at UNC for Barrett’s esophagus or esophageal cancer. The samples help researchers build a biorepository to study these conditions and support future research.
Chapel Hill, North CarolinaAges 18 years+ - NCT07224750Recruiting
A blood test to find early signs of gastrointestinal cancer
This study is testing a blood-based test to detect unique molecules (called miRNAs) that may signal the presence of several types of gut or digestive system cancers. The goal is to develop a simple screening tool that could catch these cancers earlier.
Duarte, CaliforniaAges 18 years+ - NCT06862479Enrolling by invitation
Comparing a stent to other endoscopic leak treatments
This trial compares a special stent (the Luso-Cor Stent) to other endoscopic procedures to treat leaks or abnormal connections after certain stomach or esophageal surgeries. It aims to find the best way to fix these complications using a scope.
Lisbon, Lisbon DistrictAges 18 years+ - NCT04510129Recruiting
Cancer biospecimen collection study for immunotherapy patients
This study collects samples (like tissue biopsies and imaging information) from people with certain cancers who are starting anti–PD-1/PD-L1 immunotherapy. It helps researchers gather material to study how these treatments work.
San Francisco, CaliforniaAges 18 years+ - NCT06710756RecruitingPhase 1/Phase 2
Lead-212 therapy for solid tumors
This trial tests a new radioactive drug, Lead-212 PSV359, for people with advanced solid tumors that have not responded to standard treatments. The drug is designed to find and attack cancer cells.
Los Angeles, CaliforniaAges 18–90 - NCT06123338RecruitingPhase 2
Pembrolizumab plus chemo and trastuzumab for HER2+ stomach cancer
This trial tests adding pembrolizumab to standard trastuzumab and chemotherapy for people with HER2-positive stomach or esophageal cancer that can be fully removed with surgery. The goal is to see if this combination improves outcomes before and after surgery.
Boston, MassachusettsAges 18 years+ - NCT06265285RecruitingPhase 2
Nivolumab at home vs. clinic for cancer treatment
This study compares giving the immunotherapy drug nivolumab as a shot under the skin at home versus in the clinic. It is for people with certain cancers who are already taking or starting nivolumab.
Jacksonville, FloridaAges 18 years+ - NCT07795749RecruitingPhase 2
Intraperitoneal paclitaxel with systemic therapy for gastrointestinal cancer with peritoneal spread
This study tests a treatment that combines chemotherapy given directly into the abdomen (intraperitoneal) with standard systemic chemotherapy for people whose gastrointestinal cancer has spread to the lining of the abdomen (peritoneal carcinomatosis). It aims to control the cancer and improve how patients feel.
Orange, CaliforniaAges 18 years+ - NCT06084481RecruitingPhase 1
Study of a new drug for advanced solid tumors
This study tests a new intravenous drug called ABBV-400 in people with certain advanced solid tumors that have not responded to other treatments. The goal is to see if it can slow or stop tumor growth and to check for side effects.
Duarte, CaliforniaAges 18 years+ - NCT04656041RecruitingPhase 2
Test chemo with radiation for gastroesophageal cancer
This Phase 2 study tests a combination of chemotherapy (5-FU/leucovorin plus irinotecan and oxaliplatin) together with radiation for certain types of esophagus/stomach-junction cancer. It may help shrink tumors and control cancer that is locally advanced but not spread to distant organs.
Boston, MassachusettsAges 18 years+ - NCT05059444Recruiting
Blood test to catch cancer early after treatment
This study looks for signs of cancer left in the body after treatment using a simple blood test (called a liquid biopsy). It aims to see if the test can catch cancer that might come back earlier than regular scans.
Birmingham, AlabamaAges 18 years+ - NCT03740256RecruitingPhase 1
HER2-targeted oncolytic virus plus custom immune cells for solid cancers
This Phase 1 study tests a treatment plan that combines a virus designed to attack cancer with your own custom immune cells that target HER2. It aims to shrink advanced HER2-positive solid tumors (and make future options safer/more effective).
Houston, TexasAges 18 years+ - NCT06047379RecruitingPhase 1/Phase 2
Testing NEO212 for brain tumors and metastases
This trial tests a new drug called NEO212 for people with certain brain tumors (like astrocytoma or glioblastoma) or cancer that has spread to the brain from other parts of the body. The goal is to see if it is safe and if it can help shrink or control the tumors.
Beverly Hills, CaliforniaAges 18 years+
Hear when a new Esophageal Adenocarcinoma trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.
Common questions
- Are there clinical trials for esophageal adenocarcinoma?
- Yes. Clin2 currently lists 112 recruiting esophageal adenocarcinoma studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a esophageal adenocarcinoma trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a esophageal adenocarcinoma trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
- Clinical Stage III Esophageal Adenocarcinoma AJCC v8
- Clinical Stage II Esophageal Adenocarcinoma AJCC v8
- Metastatic Esophageal Adenocarcinoma
- Clinical Stage I Esophageal Adenocarcinoma AJCC v8
- Clinical Stage IV Esophageal Adenocarcinoma AJCC v8
- Unresectable Esophageal Adenocarcinoma
- Advanced Esophageal Adenocarcinoma
- Esophageal Cancer
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.