Clinical trials
Esophageal Cancer clinical trials
Below are recruiting esophageal cancer clinical trials, each written for real people, not researchers. We’re tracking 369 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT04513808RecruitingPhase 3
Compare IV versus inhaled anesthesia for esophageal surgery
This trial tests whether using IV anesthesia (given through a vein) or inhaled anesthesia helps people live longer without their esophageal cancer coming back after surgery. You’d be randomly assigned to one anesthesia type as part of potentially curative surgery.
ShanghaiAges 18–90 - NCT00260559Recruiting
Checks quality of life after esophagus surgery
This study looks at outcomes and quality of life after esophagus removal surgery, comparing minimally invasive surgery and open surgery. It may help doctors understand how different surgical approaches affect how you feel during recovery.
Pittsburgh, PennsylvaniaAges 18 years+ - NCT04290806Recruiting
SAPHIR registry for advanced stomach and esophagus cancer
This registry collects information from people with stage IV (metastatic) stomach or esophagus cancers who are about to start their first medicines to control the disease. It may help researchers understand which treatments are used and how patients do over time.
Multiple LocationsAges 18 years+ - NCT06545331RecruitingPhase 1
A study of XB010 for advanced solid tumors
This trial tests an investigational drug called XB010 for people with solid tumors that have spread or cannot be removed by surgery. It aims to see if XB010 is safe and effective for several cancer types, including lung, breast, head and neck, and esophageal cancers.
Irvine, CaliforniaAges 18 years+ - NCT07675967Recruiting
Blood Cell Changes During Cancer Treatment
This study is for people with solid tumors who are about to start chemotherapy or radiation. It looks at how these treatments affect blood cells and may help doctors understand changes in blood health over time.
Boston, MassachusettsAges 18 years+ - NCT07795749RecruitingPhase 2
Intraperitoneal paclitaxel with systemic therapy for gastrointestinal cancer with peritoneal spread
This study tests a treatment that combines chemotherapy given directly into the abdomen (intraperitoneal) with standard systemic chemotherapy for people whose gastrointestinal cancer has spread to the lining of the abdomen (peritoneal carcinomatosis). It aims to control the cancer and improve how patients feel.
Orange, CaliforniaAges 18 years+ - NCT07518043RecruitingPhase 1
HLX18 vs. Opdivo after surgery for solid tumors
This trial compares two immune-boosting drugs (HLX18 and Opdivo, also called nivolumab) in patients who have had surgery to remove certain cancers—including esophageal, melanoma, or bladder cancer—with no signs of cancer remaining. The goal is to see which drug helps prevent the cancer from coming back.
FuzhouAges 18–70 - NCT06923020Enrolling by invitation
Nutrition and immunotherapy for advanced stomach and esophagus cancer
This trial looks at how your nutrition status affects the success of immunotherapy drugs in people with advanced esophageal squamous cell cancer or stomach adenocarcinoma that has spread. It aims to find if better nutrition leads to better treatment results.
Zhengzhou, HenanAges 18 years+ - NCT05875870Recruiting
Bright light and exercise program for lung or esophageal cancer
This trial tests whether a structured bright-light exposure routine combined with a specific exercise program can help people with newly diagnosed lung or esophageal cancer. You may be eligible if you’re in early-to-middle cancer stages and able to safely participate in walking-based activities.
Taipei City, TaipeiAges 20 years+ - NCT07224750Recruiting
A blood test to find early signs of gastrointestinal cancer
This study is testing a blood-based test to detect unique molecules (called miRNAs) that may signal the presence of several types of gut or digestive system cancers. The goal is to develop a simple screening tool that could catch these cancers earlier.
Duarte, CaliforniaAges 18 years+ - NCT06523374Recruiting
Studying quality of life and cancer risk in Barrett's esophagus
This study looks at how Barrett's esophagus affects your quality of life and fear of cancer. It uses new tests to better predict who might develop esophageal cancer, so you can get the right care sooner.
Edegem, AntwerpenAges 18 years+ - NCT05177133RecruitingPhase 2
First-line treatment for MSI-high stomach or esophagus cancer
This Phase 2 trial tests whether adding an anti–PD-1 immunotherapy (retifanlimab) and chemotherapy (capecitabine plus oxaliplatin, with leucovorin) works better for people with metastatic or inoperable stomach or gastroesophageal junction cancer that has defective mismatch repair (dMMR). If you’re eligible, it may help shrink tumors and slow the disease without needing prior chemotherapy for metastatic cancer.
AmsterdamAges 18 years+ - NCT07071103RecruitingPhase 2
Low-dose radiation and immunotherapy for resistant solid tumors
This trial tests a combination of low-dose radiation to the intestines and immunotherapy for people whose cancer has stopped responding to standard treatments including immunotherapy. It may offer a new option when other therapies have failed.
Shantou, GuangdongAges 18–80 - NCT04114136RecruitingPhase 2
Study tests pembrolizumab or nivolumab plus a diabetes-like drug
This Phase 2 study tests whether adding a metabolic (diabetes-related) medicine to an immune therapy (pembrolizumab or nivolumab) can better control certain solid tumors. It may help people whose standard treatment would usually be pembrolizumab or nivolumab alone.
Pittsburgh, PennsylvaniaAges 18 years+ - NCT05804331Recruiting
Endoscopy treatment study for large upper stomach/throat lesions
This trial studies a specialized endoscopy procedure to remove larger abnormal growths in the upper digestive tract. It may help people whose lesion size and depth make certain removal techniques a better fit.
Sydney, New South WalesAges 18 years+ - NCT06753747RecruitingPhase 1/Phase 2
Afatinib and palbociclib for advanced esophageal cancer
This trial tests a combination of two targeted drugs (afatinib and palbociclib) for people with advanced esophageal squamous cell carcinoma that has grown after previous treatment. It is designed for those whose cancer cells have too much of a protein called EGFR.
Chengdu, SichuanAges 18–75 - NCT06160557Enrolling by invitation
Radiation after endoscopic surgery for superficial esophageal cancer
This trial tests if adding radiation therapy after endoscopic surgery (ESD) helps people with early-stage esophageal cancer that had certain high-risk features, like deeper invasion or positive margins. It aims to improve outcomes for those who didn't get a complete cure with surgery alone.
Fuzhou, FujianAges 18–75 - NCT05677490RecruitingPhase 3
Chemotherapy with or without immunotherapy for advanced stomach or esophagus cancer
This trial compares two chemotherapy combinations, with or without an immunotherapy drug called nivolumab, for people with advanced stomach, esophagus, or gastroesophageal junction cancer that cannot be removed by surgery. The goal is to see which treatment works better and if adding immunotherapy helps.
Birmingham, AlabamaAges 18 years+ - NCT05984342RecruitingPhase 1
Tislelizumab plus chemo after surgery for lymph node-positive esophageal cancer
This trial tests whether adding the immunotherapy drug tislelizumab to standard chemotherapy after surgery can help prevent esophageal cancer from coming back. It is for people whose cancer had spread to lymph nodes at the time of surgery.
Shantou, GuangdongAges 18–70 - NCT06463834RecruitingPhase 2
Sintilimab plus chemo before surgery for esophageal cancer
This study tests a combination of an immunotherapy drug (sintilimab) with chemotherapy given before surgery for a type of esophageal cancer called squamous cell carcinoma. The goal is to see if this treatment shrinks the tumor and improves outcomes.
Fuzhou, FujianAges 18–75 - NCT05495152RecruitingPhase 3
Sintilimab after esophageal surgery to help prevent cancer return
This trial looks at adding sintilimab (an immunotherapy) after surgery for certain stages of esophageal squamous cell cancer. The goal is to lower the chance the cancer comes back after standard treatment.
Zhengzhou, HenanAges 18–70 - NCT06840704RecruitingPhase 3
Can immunonutrition reduce esophagitis during lung cancer radiation?
This trial tests if a special nutritional supplement (immunonutrition) can lower the risk of severe throat and chest irritation (esophagitis) caused by radiation therapy for lung cancer. You may qualify if you are about to start chest radiation and can eat normally.
Changsha, HunanAges 18 years+ - NCT07182149RecruitingPhase 1
Testing a new drug for advanced solid tumors
This trial tests a new drug called NRM-823 for people with several types of advanced cancer that have stopped responding to standard treatments. The goal is to see if the drug is safe and how well it works.
Denver, ColoradoAges 18 years+ - NCT06828588RecruitingEarly Phase 1
A new imaging test for people on HER2 cancer therapy
This study tests a new imaging drug called [68Ga]Ga-ABY-025 to see how well it shows HER2-positive tumors in people who are about to start or have just started HER2-targeted cancer therapy. It may help doctors see if the treatment is working.
Nashville, TennesseeAges 18 years+
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Common questions
- Are there clinical trials for esophageal cancer?
- Yes. Clin2 currently lists 369 recruiting esophageal cancer studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a esophageal cancer trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a esophageal cancer trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
- Breast Cancer Early Stage Breast Cancer (Stage 1-3)
- Non Small Cell Lung Cancer
- Esophageal Cancer (EsC)
- Gastric Cancer, Gastroesophageal Junction Cancer
- Lung Cancer Non-Small Cell Cancer (NSCLC)
- Breast Cancer (Triple Negative Breast Cancer (TNBC))
- Esophageal Squamous Cell Cancer
- Gastro-esophageal Junction Cancer
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.