Clinical trials
Fatigue clinical trials
Below are recruiting fatigue clinical trials, each written for real people, not researchers. We’re tracking 289 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07151391RecruitingPhase 2
Guarana to treat fatigue in neuroendocrine and gynecologic cancers
This study tests whether a natural supplement called guarana can help reduce fatigue in people with neuroendocrine tumors or certain gynecologic cancers. Participants will take guarana and report how their energy levels change.
Salt Lake City, UtahAges 18 years+ - NCT05816603RecruitingPhase 2
Stimulation treatment to help post-stroke fatigue
This Phase 2 study tests whether gentle electrical stimulation of the brain can reduce fatigue after a stroke. It may help people who are still bothered by significant tiredness at least 3 months after their stroke.
New York, New YorkAges 18 years+ - NCT05880342RecruitingPhase 3
Study how the brain affects fatigue after exercise
This trial studies how your brain responds when you feel mentally and physically tired, using trained healthy volunteers. It may help researchers understand fatigue better, which could guide future treatments for people who struggle with fatigue.
Brussels, Brussels CapitalAges 18–35 - NCT05487131Recruiting
Brain stimulation study for fatigue in healthy adults
This study tests a form of brain/nerve stimulation to see how it affects fatigue. It is looking for healthy adults, which helps researchers understand the effects without other illnesses.
Norman, OklahomaAges 18–50 - NCT06201026Recruiting
Reducing Fatigue in New MS With Individualized Training
This trial tests if a personalized home training program can help reduce severe fatigue in people with relapsing-remitting MS who were recently diagnosed. You'll use a phone app to do exercises designed for you, and researchers will check your energy levels over time.
Saint-EtienneAges 18–60 - NCT07116161Recruiting
Exercise and counseling for fatigue in female breast cancer patients
This trial tests if combining exercise with cognitive behavioral therapy (counseling) can help reduce fatigue in women with breast cancer. You may be able to join if you have completed your initial treatments and still feel tired.
SingaporeAges 21 years+ - NCT07707648RecruitingEarly Phase 1
Testing ENCER for fatigue during chemo or radiation
This trial tests if ENCER can safely help with cancer-related fatigue. You can join if you're starting a new round of chemo or radiation and can use a smartwatch and answer digital surveys.
Tel AvivAges 18 years+ - NCT07089160Recruiting
Decision fatigue and emotional exhaustion in anesthesiologists
This study looks at how tired and emotionally drained anesthesiologists in Turkey feel after making many decisions during their workday. It aims to understand the factors that lead to this (decision fatigue and emotional exhaustion) through an online survey.
Istanbul, Merkez MahallesiAges 24 years+ - NCT06480539RecruitingPhase 4
Dexmedetomidine for Better Sleep After Lung Surgery in Older Adults
This study tests whether giving a medicine called dexmedetomidine at night can help older adults sleep better and feel less tired after lung surgery. If you are 60 or older and having lung surgery through small cuts (thoracoscopy), you may be able to join.
Genk, LimburgAges 60 years+ - NCT07273097Recruiting
Ankle muscle fatigue and walking in ankle instability
This trial studies how tired ankle muscles affect walking in people with chronic ankle instability. It compares their walking patterns to healthy people to understand if fatigue makes ankle issues worse.
LjubljanaAges 18–45 - NCT03609112Recruiting
Study brain and thinking risks in children with solid tumors
This study looks at how cancer treatment may affect children’s thinking and brain health. It may help doctors better understand risks so they can monitor and support learning and memory during and after treatment.
Villejuif, Val De MarneAges Any age - NCT06830018Recruiting
New megestrol for advanced stomach or colon cancer with fatigue
This study tests a new form of megestrol (a medicine that can boost appetite and energy) for people with advanced stomach or colorectal cancer who also have fatigue and poor appetite. It is given as a first treatment, meaning you haven't had chemotherapy yet for your advanced cancer.
Shenyang, LiaoningAges 18–75 - NCT06846177Recruiting
Training programs for fatigue after stroke
This study compares two types of training—graded activity and task-oriented training—to see which one helps reduce fatigue after a stroke. If you are between 40 and 60 years old, had a stroke over 4 months ago, and often feel very tired, you may be able to join.
Mansehra, KPKAges 40–60 - NCT06819254RecruitingPhase 4
Fisetin for fatigue in older cancer survivors
This study tests whether a natural compound called fisetin can reduce fatigue in people aged 60+ who have completed cancer treatment. If you still feel tired often, this pill-based treatment might help you regain energy.
Winston-Salem, North CarolinaAges 65 years+ - NCT06529055Enrolling by invitation
Caffeine and nicotine pouch effects on exercise and brain function
This trial tests how caffeine and nicotine pouches affect your body during exercise, including heart function, thinking, and behavior. It looks at short bursts of high-intensity activity in healthy men who already exercise regularly.
Hattiesburg, MississippiAges 21–40 - NCT06980636RecruitingPhase 4
Shengmai liquid for long covid fatigue trial
This trial tests if a traditional Chinese medicine, Shengmai Liquid, can help reduce fatigue in people with long COVID. It is for adults aged 18 to 75 who feel tired for a long time after a COVID infection.
Beijing, ChinaAges 18–75 - NCT04151693Recruiting
Group therapy for chronic fatigue syndrome
This trial tests a health-psychology–based rehabilitation program delivered in a group setting for people with chronic fatigue syndrome (ME/CFS). It may help by teaching strategies to cope with symptoms and improving daily functioning through structured group support.
LahtiAges 18–65 - NCT07254169Enrolling by invitation
Herbal medicine for post-accident fatigue
This trial tests if a special herbal medicine treatment can help people who still feel very tired after a traffic accident. It aims to see if the treatment is safe and effective for reducing fatigue.
Seoul, Gangnam-GuAges 40–69 - NCT05333250RecruitingPhase 1/Phase 2
Modafinil to reduce cancer-related fatigue
This trial tests whether modafinil can improve cancer-related fatigue in people with advanced cancer. It may help you feel more able to function day to day by reducing how “worn out” you feel.
Ottawa, OntarioAges 18 years+ - NCT06634381Recruiting
Fatigue in cancer survivors: A study to learn more
This study asks cancer survivors about their fatigue (tiredness, weakness, or exhaustion) to better understand it. It involves filling out questionnaires and maybe an interview. Your participation helps doctors learn how to support survivors like you.
Charlotte, North CarolinaAges 18 years+ - NCT03675087Recruiting
Testing how exercise affects symptoms in ME/CFS
This trial studies how people with ME/CFS respond to an exercise test. It may help researchers understand what kind of exercise response is typical and how it relates to symptoms.
MadridAges 18–65 - NCT03940911Recruiting
Testing fatigue and muscle effects after starting targeted therapy
This study looks at how starting “targeted” treatment affects fatigue and skeletal muscle function in people with severe axial spondyloarthritis. It may help doctors understand what to expect early after treatment starts and how well it impacts day-to-day energy and muscle performance.
Strasbourg, Bas-RhinAges 18 years+ - NCT04049331RecruitingPhase 2
Testosterone therapy for cancer survivors with fatigue
This trial tests whether testosterone replacement can help male cancer survivors who have ongoing fatigue and low testosterone levels. It is for men who have completed chemotherapy or radiation and are cancer-free for at least a year.
Boston, MassachusettsAges 18–54 - NCT04938362Recruiting
Study brain recovery after abscess using memory and brain scans
This study looks at how thinking and energy levels change after a brain abscess. It may help researchers understand what affects recovery and fatigue, using thinking tests and brain imaging/brain-wave checks.
OsloAges 16 years+
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Common questions
- Are there clinical trials for fatigue?
- Yes. Clin2 currently lists 289 recruiting fatigue studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a fatigue trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a fatigue trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.