Clinical trials
Gastrointestinal Cancer clinical trials
Below are recruiting gastrointestinal cancer clinical trials, each written for real people, not researchers. We’re tracking 163 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07524114Recruiting
Blood test to find leftover cancer after treatment
This study uses a blood test to look for tiny bits of cancer DNA after you finish treatment. It may help doctors know if cancer is still there and guide next steps.
Toronto, OntarioAges 18 years+ - NCT04674267Recruiting
REACH study for older adults with GI cancer and support needs
This study looks at how to improve health and care support for people age 70 and older with gastrointestinal (GI) cancer. It may help by offering a structured way to address practical and emotional challenges that can affect aging and cancer care.
Boston, MassachusettsAges 70 years+ - NCT07124000Recruiting
T-DXd for advanced HER2-positive solid tumors
This trial is for people with advanced HER2-positive solid tumors (cancers that cannot be removed by surgery or have spread). It tests the drug T-DXd (also called Enhertu) when your doctor has already decided it's the right treatment for you and you have no other good options.
Birmingham, AlabamaAges 18–130 - NCT03190941RecruitingPhase 1/Phase 2
T-cell therapy for HLA-A11:01 and KRAS G12V tumors
This trial tests a custom immune-cell treatment made from your blood that targets the KRAS G12V change in certain cancers. It is for people with advanced cancer who have already tried standard treatments, and it may help your immune system recognize and attack tumor cells.
Bethesda, MarylandAges 18–72 - NCT04273061RecruitingPhase 2
Atezolizumab for tumors that look sensitive on DNA/RNA testing
This Phase 2 study tests atezolizumab, an immunotherapy drug, in people with advanced, incurable solid tumors whose tumor DNA/RNA suggests they may respond. The goal is to see if the treatment works better for patients selected by these lab results.
Vancouver, British ColumbiaAges 18 years+ - NCT04354064Recruiting
Blood DNA test to see early treatment response in solid tumors
This study looks at circulating tumor DNA, which is tiny bits of DNA found in blood, to help assess how solid tumors are responding early. It uses blood samples from healthy adults who are willing to donate.
St Louis, MissouriAges 18 years+ - NCT04907643Recruiting
Virtual reality program to reduce stomach-cancer pain
This trial tests whether virtual reality (VR) can improve pain and other day-to-day symptoms in people with certain gastrointestinal cancers. You’d use VR for pain relief while researchers measure how you’re feeling.
Los Angeles, CaliforniaAges 18–99 - NCT05406167Recruiting
Tracking quality of life during radiotherapy with a new system
This study collects information about how you feel and how treatment is delivered while you receive radiotherapy using the RefleXion Medical radiotherapy system. It may help doctors improve care and better understand what affects quality of life during treatment.
Duarte, CaliforniaAges Any age - NCT05606848Recruiting
Testing a special nutrition drink around surgery for gut cancer
This study tests whether a special medical nutrition (a drink/food meant for people who need medical nutrition) given around the time of surgery helps patients with gastrointestinal cancer recover better. It aims to see if this nutrition approach is safe and beneficial when cancer is being removed.
BeijingAges 18–75 - NCT05789485RecruitingPhase 2
Exercise program to reduce treatment side effects in GI cancer
This trial studies whether a structured exercise plan can lessen side effects from chemotherapy in people with colorectal or stomach/esophagus solid tumors. If you’re about to start chemotherapy, the study will check whether exercising helps you feel and function better during treatment.
Hartford, ConnecticutAges 18 years+ - NCT05837767Recruiting
Radiation study for tumors that spread to soft tissue areas
This study looks at how a planned form of palliative radiation therapy treats certain solid cancers that have spread outside the brain to larger soft-tissue areas. It may help shrink tumors and relieve symptoms, but it also asks you to meet specific safety and treatment-timing rules.
Basking Ridge, New JerseyAges 18 years+ - NCT06263088Recruiting
Equity in GI Cancer Care Study
This trial is looking for Black patients newly diagnosed with any stage of gastrointestinal cancer to help improve cancer care and make sure research includes everyone. By joining, you help doctors learn how to better support patients like you.
Cleveland, OhioAges 18 years+ - NCT06420206Recruiting
Goals of care discussion in the ER for advanced cancer
This study is for people with advanced lung or GI cancer who come to the emergency room at MD Anderson. It’s testing a conversation to help you and your doctor discuss your goals and wishes for care.
Houston, TexasAges 18 years+ - NCT07529808RecruitingPhase 1/Phase 2
New Drug BHB810 for Advanced Stomach Cancer
This trial tests a new drug called BHB810 for gastric (stomach) and gastroesophageal junction cancer that has stopped responding to standard treatments or has no standard options available. The drug targets a protein called CDH17 found on cancer cells and may help slow or shrink the tumor.
Fairfax, VirginiaAges 18 years+ - NCT06731998Recruiting
Improving pain control after cancer surgery
This study compares different methods of managing pain after minimally invasive surgery for abdominal cancers. It aims to find which approach works best to reduce pain and improve recovery.
Pittsburgh, PennsylvaniaAges 18–89 - NCT07329894RecruitingPhase 1
XH001 and vaccine-activated T cells for advanced GI cancer
This trial tests a two-part treatment: an injection called XH001 plus a custom vaccine that trains your immune cells to attack tumors. It's for people with advanced stomach or bowel cancer that hasn't responded to at least two prior treatments.
BeijingAges 18–70 - NCT01313442Recruiting
Give blood and tumor samples for gastrointestinal cancer research
This trial collects blood and tumor tissue from adults with cancer to help researchers study gastrointestinal cancers. If you’re eligible, your participation mainly involves donating samples for research purposes.
Bethesda, MarylandAges 18 years+ - NCT02012699Recruiting
Cancer registry for people with or at risk of cancer
This trial collects health information and samples (a “cancer repository”) to help researchers study cancer and cancer risk. You may be able to join if you’ve had cancer before or if you’re at higher risk or have concerning findings.
Greenwood Village, ColoradoAges 19–110 - NCT02906943Recruiting
Testing cancer tissue to guide targeted treatment choices
This trial studies advanced solid tumors by using stored tumor samples to look for molecular clues. The goal is to help doctors better choose cancer treatments that may work for your specific tumor.
Hamilton, OntarioAges 18 years+ - NCT07056777RecruitingPhase 1/Phase 2
DR30206 plus standard therapy for advanced GI cancer
This trial tests a new drug called DR30206 combined with standard therapy for advanced gastrointestinal cancers. It may be an option if you have colorectal, esophageal, gastric, or gastroesophageal junction cancer and have had little or no prior chemotherapy.
Guangzhou, GuangdongAges 18–75 - NCT07462247Recruiting
Creating an Image Database for Early Upper GI Cancer
This study aims to build a library of images from patients with early cancers or precancerous spots in the upper digestive tract (esophagus and stomach). If you are scheduled for a standard endoscopy procedure (ESD or biopsy), researchers will use the pictures to help improve early detection.
ShanghaiAges 18 years+ - NCT07561840Recruiting
Exercise Training After Stomach or Esophagus Cancer Surgery
This study tests whether a guided exercise program helps people recover better after surgery for esophageal or gastric (stomach) cancer. Researchers will track your strength, fitness, and quality of life over time.
Hirakata, OsakaAges 18 years+ - NCT07050485Enrolling by invitation
Postbiotic gummies after GI cancer surgery
This trial tests if taking postbiotic gummies (a type of supplement that helps good gut bacteria) can help your gut recover faster after surgery for stomach, colon, or other gastrointestinal cancers. It is for people having scheduled, minimally invasive (laparoscopic) surgery to remove their cancer.
Tampa, FloridaAges 18 years+ - NCT07539311RecruitingPhase 2
Testing Rina-S for Advanced Gastrointestinal Cancers
This study tests a new drug called Rina-S in people with advanced gastrointestinal cancers (like stomach, colon, or pancreatic cancer) that have spread or cannot be surgically removed. The drug is designed to help slow or stop cancer growth in people whose cancer has gotten worse despite recent treatment.
Grand Rapids, MichiganAges 18 years+
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Gastrointestinal Cancer trials by city
Studies with a site in or near these metro areas.
Gastrointestinal Cancer trials by state
Studies with a site anywhere in these states.
Common questions
- Are there clinical trials for gastrointestinal cancer?
- Yes. Clin2 currently lists 163 recruiting gastrointestinal cancer studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a gastrointestinal cancer trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a gastrointestinal cancer trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
- Breast Cancer Early Stage Breast Cancer (Stage 1-3)
- Non Small Cell Lung Cancer
- Gastric Cancer, Gastroesophageal Junction Cancer
- Lung Cancer Non-Small Cell Cancer (NSCLC)
- Gastrointestinal Cancer Metastatic
- Breast Cancer (Triple Negative Breast Cancer (TNBC))
- Cancer of Gastrointestinal Tract
- Upper Gastrointestinal Cancer
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.