Clinical trials
GBM clinical trials
Below are recruiting gbm clinical trials, each written for real people, not researchers. We’re tracking 86 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06632236RecruitingPhase 1
Amivantamab for advanced brain tumors
This trial tests a new drug called amivantamab for people with advanced brain tumors, including glioblastoma. It aims to see if the drug can shrink or slow tumor growth.
CambridgeAges 16 years+ - NCT06649851RecruitingPhase 2
G-CSF to reduce side effects during glioblastoma treatment
This trial is testing whether a drug called G-CSF (which helps boost white blood cells) can help people with glioblastoma who are already receiving standard treatment with radiation and chemotherapy (temozolomide). It aims to see if G-CSF can reduce side effects and improve outcomes.
Boston, MassachusettsAges 18 years+ - NCT06717295Recruiting
Blood test to find cancer early and track treatment
This study uses a blood test that looks at your platelets and immune cells to find common cancers early, and for certain cancers, to monitor how well treatment is working.
RosarioAges 40–75 - NCT06757153RecruitingEarly Phase 1
NRG-103 injection for recurrent glioblastoma patients
This trial tests an injection called NRG-103 given directly into the cavity where a recurrent brain tumor was removed. It is for people with glioblastoma that has come back and who have already had standard treatments.
Wuhan, HubeiAges 18 years+ - NCT06773481RecruitingPhase 1
BC008-1A injection for recurrent grade 4 glioma
This trial tests a new injection called BC008-1A for people with a grade 4 glioma (a type of brain cancer) that has come back after standard treatment. The goal is to see if the drug can help control the tumor and improve outcomes.
Beijing, Beijing MunicipalityAges 18 years+ - NCT06835803RecruitingPhase 2
Intensified radiation for older adults with glioblastoma
This trial tests whether a more focused, stronger dose of radiation can improve outcomes for people 65 and older with newly diagnosed glioblastoma. It compares this approach to standard radiation to see if it's safe and effective.
Boston, MassachusettsAges 65 years+ - NCT06850766Recruiting
Timing of chemotherapy (morning vs evening) for glioblastoma
This trial tests whether taking the chemotherapy drug temozolomide in the morning or in the evening works better and causes fewer side effects for people with a type of brain cancer called glioblastoma.
London, OntarioAges 18 years+ - NCT06926075RecruitingPhase 1/Phase 2
Early trial of KESONOTIDE™ for solid tumors
This trial tests a new tablet called KESONOTIDE™ for people with solid tumors that have spread. The goal is to see if it can help when other treatments have stopped working or are not an option.
Kogarah, New South WalesAges 18 years+ - NCT06936046RecruitingPhase 2
Enhanced treatment for newly diagnosed GBM with partial resection or early progression
This trial tests a stronger combination of treatments given after surgery for people with glioblastoma (GBM) that was only partially removed or that starts growing again quickly. It aims to see if this approach can help control the tumor better. You may be eligible if you are newly diagnosed, over 18, have good organ function, and do not have other serious health issues.
HangzhouAges 18 years+ - NCT06989086Recruiting
FearLess support for brain tumor patients and caregivers
This study tests a program to help people with brain tumors and their caregivers manage fear of recurrence. You would attend virtual sessions to learn coping skills.
Richmond, VirginiaAges 18 years+ - NCT07143812RecruitingPhase 1
Stem cell gene therapy for newly diagnosed glioblastoma
This trial tests a new stem cell-based gene therapy for people with newly diagnosed glioblastoma who have already received standard treatment. The goal is to see if it is safe and potentially effective.
Seongnam, KyunggidoAges 19–70 - NCT07145047RecruitingPhase 1/Phase 2
Oncolytic virus trial for recurrent glioblastoma
This trial tests a virus-based treatment for glioblastoma that has come back after standard therapies. The virus is designed to infect and destroy cancer cells while leaving healthy cells alone.
Mianyang, SichuanAges 18–70 - NCT07193654RecruitingPhase 2
Combined stupp therapy and spinal chemo for advanced glioblastoma
This trial tests adding a chemotherapy drug (thiotepa) directly into the spinal fluid for people with a newly diagnosed glioblastoma that has spread to the brain's lining or ventricles. It aims to see if this extra treatment can help control the cancer.
Hangzhou, ZhejiangAges 18–75 - NCT07209241RecruitingPhase 1
CAR-T cell therapy for recurrent glioblastoma
This study tests a new type of immunotherapy called CAR-T cells that are designed to attack two markers on your brain tumor cells (EGFR and IL13Ra2). The goal is to find the best way to give these cells after surgery and see if they can help control the tumor.
Philadelphia, PennsylvaniaAges 18 years+ - NCT07268053RecruitingEarly Phase 1
B7-H3 drug for recurrent brain tumor or brain metastases
This trial tests a drug called GSK5764227 (a B7-H3 targeted antibody-drug conjugate) in people whose glioblastoma has come back after standard treatment, or who have brain metastases that need surgery. The goal is to see if the drug can help shrink or control the tumor.
Phoenix, ArizonaAges 18 years+ - NCT07338539Recruiting
Shorter radiation for poor-prognosis GBM
This trial tests a shorter course of radiation (hypofractionated RT) for people with a specific type of aggressive brain tumor (GBM) that is not suitable for surgery. It aims to see if this shorter treatment can be effective with fewer side effects.
Mumbai, MaharashtraAges 50 years+ - NCT07343986RecruitingPhase 1
Ultrasound and Immunotherapy for Newly Diagnosed Brain Cancer
This trial tests whether a special ultrasound (LIFU) can open the blood-brain barrier to help an immunotherapy drug (cetuximab) reach glioblastoma tumors better. It is for people with a specific type of glioblastoma that has not been treated yet and that has a certain protein called EGFR.
Charlottesville, VirginiaAges 18–70 - NCT07346144RecruitingPhase 1/Phase 2
Gene therapy study for high-grade glioma
This trial tests a new gene therapy given directly into the brain tumor. It's for people with high-grade glioma, either newly diagnosed or after one recurrence, to see if it can help control the tumor.
Columbus, OhioAges 18–70 - NCT07387666RecruitingEarly Phase 1
Imaging a common drug in glioblastoma
This trial uses a special imaging technique to see how the drug Acetadote (often used for acetaminophen overdose) behaves in glioblastoma tumors. It may help doctors learn more about the tumor and could guide future treatments.
Dallas, TexasAges 18 years+ - NCT07391215RecruitingPhase 1/Phase 2
Paxalisib for newly diagnosed glioblastoma after standard treatment
This trial tests a drug called paxalisib in people with a newly diagnosed aggressive brain tumor (glioblastoma) who have just finished standard radiation and chemotherapy. The goal is to see if adding paxalisib can help prevent the tumor from coming back by targeting a specific pathway in the cancer cells.
SuttonAges 16 years+ - NCT01269853RecruitingPhase 1/Phase 2
Bevacizumab directly into brain arteries for recurrent brain tumors
This early-stage trial tests whether giving a targeted cancer medicine (bevacizumab) directly into brain arteries can help shrink or control certain recurrent (coming back) brain tumors. It may be an option if standard treatments are no longer working.
New York, New YorkAges 18 years+ - NCT02800486RecruitingPhase 2
Targeted antibody plus repeat radiation for recurrent brain tumors
This trial studies giving cetuximab (a targeted antibody) directly into an artery along with repeat radiation to treat certain recurring or treatment-resistant brain tumors. It may help by delivering the drug more directly to tumor areas and testing whether this approach can control the disease after it comes back.
New York, New YorkAges 18 years+ - NCT02861898RecruitingPhase 1/Phase 2
Cetuximab delivered into the brain tumor artery for new glioblastoma
This Phase 1/2 study tests whether giving cetuximab directly into the artery that feeds the brain tumor can help people with newly diagnosed glioblastoma. It aims to target the tumor more precisely while checking safety and early signs of benefit.
New York, New YorkAges 18 years+ - NCT07409584Recruiting
Mental health and suicide risk in glioblastoma patients
This study looks at the mental health and thoughts of suicide in people with glioblastoma. It aims to understand these issues better so that patients can get the right support.
BerlinAges 18 years+
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Common questions
- Are there clinical trials for gbm?
- Yes. Clin2 currently lists 86 recruiting gbm studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a gbm trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a gbm trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.