Clinical trials · California
Health clinical trials in California
We’re tracking 342 recruiting health studies with a site in California — including Phase 1 and Phase 2 studies, each written for real people, not researchers.
Recruiting studies in California
- NCT06952491Enrolling by invitation
Substance use support program
This study tests an online program that offers personalized education and support to help people who use substances improve their well-being and feel more confident in managing their health.
San Mateo, CaliforniaAges 21 years+ - NCT05772130Recruiting
Help family members get cancer genetic test results and counseling
This study tests a family-centered way to share cancer genetic testing results with close relatives, so more relatives get genetic counseling and testing. It may help your eligible family members understand their risk and get the right next steps.
Duarte, CaliforniaAges 18 years+ - NCT07650656RecruitingPhase 2
Fluorescence-Guided Surgery to Improve Sarcoma Tumor Removal
This trial tests a special dye and imaging technique to help surgeons see and remove sarcoma tumors more completely. The goal is to reduce the chance that cancer cells are accidentally left behind during surgery.
Duarte, CaliforniaAges Any age - NCT04420156Recruiting
Study to understand eye disease risk in premature babies
This study looks at newborn eye exams and genetic information to better understand why some premature infants develop a serious vision problem called ROP. You may be invited because your baby needs routine eye screening or is being moved for specialized eye care.
Palo Alto, CaliforniaAges Up to 1 year - NCT05218044Recruiting
Cryoablation for small DCIS instead of breast surgery
This trial studies whether cryoablation (freezing abnormal breast tissue) can treat DCIS, a non-invasive early breast cancer, without surgical lumpectomy. It aims to see if a less invasive approach could help people with small, limited-area DCIS while avoiding some effects of surgery.
Glendale, CaliforniaAges 18 years+ - NCT05588583Recruiting
Tracking drainage from chronic leg or foot ulcers with a dressing
This study follows how much fluid (drainage) a chronic ulcer produces over time using a dressing called Mepilex Up. It may help clinicians better understand how this dressing manages “exuding” ulcers on the leg or foot.
Castro Valley, CaliforniaAges 18 years+ - NCT05475262Recruiting
Inpatient sleep study using white noise
This study looks at whether playing white noise helps people sleep better while they are in the hospital. If you’re an adult admitted for several days, you may be able to join.
La Jolla, CaliforniaAges 18 years+ - NCT07723924RecruitingPhase 2
Plecanatide for constipation in children and teens
This study tests a new medicine called plecanatide for children and teens with functional constipation. It aims to see if it helps improve bowel movements compared to a placebo (a pill with no medicine).
San Bernardino, CaliforniaAges 6–17 - NCT03085875Recruiting
Healthy Pregnancy Study for Moms Using Phone Apps
This study looks at healthy pregnancy habits and support for expecting moms (and moms up to 8 weeks after delivery) through a research community. It may help you compare or improve health behaviors with guidance and study activities delivered on your phone or tablet.
La Jolla, CaliforniaAges 16 years+ - NCT05608317Recruiting
Track healing of draining leg ulcers with a foam dressing
This study follows how a non-bordered foam dressing helps chronic leg ulcers that leak fluid (exuding). It mainly aims to see how the wound changes over time, and whether the dressing is comfortable and effective along with standard care.
San Francisco, CaliforniaAges 18 years+ - NCT07849140Recruiting
Hands-on therapy for painful periods
This study tests whether osteopathic manipulative treatment (a hands-on approach to relieve tension and improve blood flow) can reduce the pain and other symptoms of painful periods. It is only for people at Western University of Health Sciences.
Pomona, CaliforniaAges 20–51 - NCT06393101RecruitingPhase 1
High-CBD cannabis extract for complex regional pain syndrome treatment
This study tests a high-CBD cannabis extract (BRC-002) to see if it can help reduce pain and improve health in people with Complex Regional Pain Syndrome (CRPS). Participants will not use opioids or other cannabis during the study.
La Jolla, CaliforniaAges 21–75 - NCT05197738Recruiting
Study using a sleep health app to improve sleep
This study tests a “sleep health” app (REFRESH) to see how it may help people track and improve sleep. You may be eligible if you’re an adult in the U.S. who can use the app on your own phone.
La Jolla, CaliforniaAges 18 years+ - NCT06486688Recruiting
Virtual program to help teens with substance use risk
This trial tests a virtual program integrated into pediatric check-ups to help teens at risk for alcohol or drug problems. It aims to identify teens who may need extra support and connect them with helpful resources.
Pleasanton, CaliforniaAges 12–17 - NCT07817147Recruiting
Microwave ablation treatment for advanced cancer
This study tests a procedure called microwave ablation (using heat to destroy cancer cells) for tumors that are hard to remove with surgery. It aims to see if the procedure is safe and effective when done through a scope in the stomach.
Los Angeles, CaliforniaAges 18 years+ - NCT05471232Recruiting
Genomic testing for youth mental health crises with IDD
This study looks at genetic (DNA) information to understand mental health crises in youth with intellectual and developmental disabilities. It may help doctors learn why these crises happen and improve how future families are supported.
San Diego, CaliforniaAges 7–17 - NCT07775976Enrolling by invitation
Whole-heart checkup with a wearable heart monitor
This study looks at how well a wearable heart monitor and special software can check the health of your whole heart and assess your risk of future heart problems. It may help doctors create more personalized care plans.
Pasadena, CaliforniaAges 18 years+ - NCT07776353Recruiting
Understanding weight loss in advanced cancer
This study looks at how weight loss and muscle loss affect people with advanced cancer. It aims to find different types of weight loss to better guide treatment and care.
Pleasanton, CaliforniaAges 18 years+ - NCT07776678Recruiting
Body fat and muscle measurement study
This study uses advanced body scans (like MRI and DXA) to better measure body fat and muscle. It may help improve how obesity is diagnosed and treated.
Menlo Park, CaliforniaAges 18 years+ - NCT07775495Recruiting
Urine light patterns for microplastic exposure
This research study uses photographs of urine samples to explore how microplastics and nanoplastics in the environment might show up in your body. It is observational, meaning you will not receive treatment, but your participation could help scientists better understand everyday plastic exposure.
San Francisco, CaliforniaAges 18 years+ - NCT07775534Recruiting
Tear fluid test for glioblastoma detection
This study looks at tear fluid to find tiny particles released by glioblastoma tumors, which could offer a new way to monitor the disease. Participation involves a simple, non-invasive tear collection with a small paper strip.
Duarte, CaliforniaAges 18 years+ - NCT07755748Recruiting
Glaucoma screening survey response study
This study tests different ways to encourage people to respond to a survey about glaucoma screening. It aims to improve how we reach and screen people at risk for glaucoma in California.
Oakland, CaliforniaAges 50 years+ - NCT07730268Enrolling by invitation
Vivio at-home study for heart failure monitoring
This study tests a home monitoring device (Vivio) for people who already have a CardioMEMS implant to check if the new device can track your heart health easily at home.
Los Angeles, CaliforniaAges 21 years+ - NCT06631365RecruitingPhase 2
PrEP on demand: a pilot study for men who have sex with men
This study tests a '2-1-1' on-demand PrEP strategy for cisgender men who have sex with men. It aims to see if taking PrEP only around the time of sex is safe and effective. If you are interested in starting or currently taking PrEP this way, you may be eligible.
San Francisco, CaliforniaAges 18 years+
Where these studies are running in California
Institutions with a site for the recruiting health studies listed above.
- City of Hope · 3 studies
- Advanced Research Center (ARC)
- Altman Clinical and Translational Research Institute
- Baywell Health
- Bridge HIV, San Francisco Department of Public Health
- Cedars-Sinai Medical Center
- Center for Clinical Research, Inc.
- Center for Clinical Trials, Inc.
What taking part in a health study involves
A screening visit first
Before anything else, the study team checks whether you fit — usually a visit with some tests. You can stop at any point, and screening is typically free.
Care at a nearby site
Study visits happen at a clinic or hospital taking part. Many studies cover the cost of the study treatment and related visits, and some reimburse travel.
You stay in control
Taking part is voluntary and you can leave a study at any time, for any reason, without affecting your regular care.
The team decides eligibility
Our fit check is a helpful first read, not a decision. The study team makes the final call after reviewing your health history.
Common questions
- Are there health clinical trials in California?
- Yes. We're currently tracking 342 recruiting health studies with a site in California, each rewritten in plain language so you can see what it's testing and who it's for.
- How do I find out if I qualify for a health study in California?
- Each study lists its eligibility rules — age, diagnosis, prior treatments. On every trial page we explain these in plain language and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Do I have to live in California to take part?
- Not necessarily. These studies have a site in California, but eligibility is about your health, not your address — some people travel to take part, and a few studies reimburse travel. The study team can tell you what's required.
- Does it cost anything to join a health trial?
- Using Clin2 is always free. Many trials cover the study treatment and related visits; some reimburse travel. The study team explains exactly what's covered before you decide.
Not the right time?
New health studies open in California regularly. Set up a health profile and we’ll quietly watch for studies that fit you and email you when one opens.
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.