Clinical trials · North Carolina
Heart Failure With Reduced Ejection Fraction clinical trials in North Carolina
We’re tracking 13 recruiting heart failure with reduced ejection fraction studies with a site in North Carolina — including Phase 2 and Phase 3 studies, each written for real people, not researchers.
Recruiting studies in North Carolina
- NCT06736574RecruitingPhase 3
Study of omecamtiv mecarbil for chronic heart failure with very weak heart pump
This study tests an investigational medicine (omecamtiv mecarbil) for people with chronic heart failure and very low pumping strength. It looks at whether the drug can help prevent heart failure events or the need for stronger treatments.
Cary, North CarolinaAges 18–85 - NCT04592445Recruiting
Nerve ablation for right-sided symptoms in HFpEF heart failure
This trial tests a procedure to “turn off” the right greater splanchnic nerve to improve symptoms in people with HFpEF (heart failure with preserved pumping function). If successful, it may reduce shortness of breath and fluid congestion in daily life.
Durham, North CarolinaAges 40 years+ - NCT05064709Recruiting
Test device for heart failure symptoms in some patients
This study tests whether a heart-related device called CCM can improve symptoms and daily function in people with heart failure and a moderately reduced pumping strength. It may help if you’ve had recent heart-failure-related hospital care or urgent treatment and your heart and overall health fit the study limits.
Charlotte, North CarolinaAges 18 years+ - NCT05650658Recruiting
Compare two heart pacing options in people with weak heart function
This trial compares two types of “left-side” heart pacing to see which one works better in people with weak heart pumping. It may help guide the best pacing choice for improving heart function and symptoms.
Asheville, North CarolinaAges 18 years+ - NCT05839067Recruiting
Support program for U.S. veterans living with heart failure
This trial supports U.S. Veterans who have heart failure, to see whether the added support improves health and well-being. You may be able to join if you meet the age, diagnosis, and communication requirements.
Durham, North CarolinaAges 18 years+ - NCT06699056Recruiting
AI heart monitor study for ejection fraction
This study uses an AI-powered wearable monitor to check how well your heart pumps blood (ejection fraction) from a simple EKG recording. It may help doctors quickly assess heart function without extra tests.
Greensboro, North CarolinaAges 18 years+ - NCT06008197RecruitingPhase 3
A study of finerenone for hospitalized heart failure patients
This trial tests a medication called finerenone to see if it helps people hospitalized for heart failure live longer and have fewer heart-related problems. It may be an option for those with a certain type of heart failure where the heart's pumping strength is mildly reduced or normal.
Greenville, North CarolinaAges 18 years+ - NCT06733012Recruiting
Nerve block trial for heart failure patients
This trial tests a nerve block procedure to improve heart function in people with heart failure and reduced pumping ability. It aims to see if blocking certain nerves can help you feel better and be more active.
Durham, North CarolinaAges 18 years+ - NCT07084142Recruiting
Digital aid for ICD decisions
This study is developing a digital tool to help people 70 and older with heart failure decide whether an ICD (a device that prevents dangerous heart rhythms) is right for them. Participants will help test and improve this tool.
Greenville, North CarolinaAges 60 years+ - NCT07131631Recruiting
MitraClip for leaky heart valve in heart failure patients
This trial tests if the MitraClip device helps people with heart failure and a leaky mitral valve. It uses a special MRI to check how the heart responds to treatment.
Charlotte, North CarolinaAges 18 years+ - NCT07037459RecruitingPhase 3
A study of a new drug for heart failure with obesity
This trial tests a medication called maridebart cafraglutide for people with heart failure (where the heart doesn't pump as well as it should) and obesity. The goal is to see if it can help improve symptoms and outcomes.
Durham, North CarolinaAges 18–99 - NCT06937320Enrolling by invitationPhase 2
Testing ketone supplements for heart failure with preserved ejection fraction (HFpEF)
This study tests whether a special dietary supplement (ketone esters) can improve exercise ability and heart function in people with a type of heart failure where the heart pumps well but is stiff (HFpEF). You might join if you have stable symptoms, an ejection fraction of 50% or higher, and signs of fluid buildup in the heart.
Durham, North CarolinaAges 18 years+ - NCT06195982Enrolling by invitationPhase 2
Ketone supplement for heart failure with reduced pumping ability
This trial tests whether a ketone supplement can improve heart function and exercise ability in people with heart failure and a reduced ejection fraction. It may help you feel better during daily activities.
Durham, North CarolinaAges 18 years+
Heart Failure With Reduced Ejection Fraction trials by city in North Carolina
Where these studies are running in North Carolina
Institutions with a site for the recruiting heart failure with reduced ejection fraction studies listed above.
- Cone Health Cancer Center · 2 studies
- Duke University · 2 studies
- Duke University Medical Center · 2 studies
- Sanger Heart and Vascular Institute · 2 studies
- Accellacare
- Asheville Cardiology Associates
- Cary Cardiology
- Duke
What taking part in a heart failure with reduced ejection fraction study involves
A screening visit first
Before anything else, the study team checks whether you fit — usually a visit with some tests. You can stop at any point, and screening is typically free.
Care at a nearby site
Study visits happen at a clinic or hospital taking part. Many studies cover the cost of the study treatment and related visits, and some reimburse travel.
You stay in control
Taking part is voluntary and you can leave a study at any time, for any reason, without affecting your regular care.
The team decides eligibility
Our fit check is a helpful first read, not a decision. The study team makes the final call after reviewing your health history.
Heart Failure With Reduced Ejection Fraction trials in other states
Common questions
- Are there heart failure with reduced ejection fraction clinical trials in North Carolina?
- Yes. We're currently tracking 13 recruiting heart failure with reduced ejection fraction studies with a site in North Carolina, each rewritten in plain language so you can see what it's testing and who it's for.
- How do I find out if I qualify for a heart failure with reduced ejection fraction study in North Carolina?
- Each study lists its eligibility rules — age, diagnosis, prior treatments. On every trial page we explain these in plain language and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Do I have to live in North Carolina to take part?
- Not necessarily. These studies have a site in North Carolina, but eligibility is about your health, not your address — some people travel to take part, and a few studies reimburse travel. The study team can tell you what's required.
- Does it cost anything to join a heart failure with reduced ejection fraction trial?
- Using Clin2 is always free. Many trials cover the study treatment and related visits; some reimburse travel. The study team explains exactly what's covered before you decide.
Not the right time?
New heart failure with reduced ejection fraction studies open in North Carolina regularly. Set up a health profile and we’ll quietly watch for studies that fit you and email you when one opens.
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.