Testing ketone supplements for heart failure with preserved ejection fraction (HFpEF)
Part of Heart & circulation, Hormones & metabolism, Immune system & allergy, Lungs & breathing clinical trials.
This study tests whether a special dietary supplement (ketone esters) can improve exercise ability and heart function in people with a type of heart failure where the heart pumps well but is stiff (HFpEF). You might join if you have stable symptoms, an ejection fraction of 50% or higher, and signs of fluid buildup in the heart.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are 18 years or older.
- You have stable heart failure symptoms (NYHA class II or III).
- Your heart's pumping strength (ejection fraction) is 50% or higher.
- You have signs of increased pressure or fluid in your heart (like an enlarged upper chamber, or need water pills daily, or high BNP levels).
- You are not on a strict ketogenic diet, don't have cirrhosis or heavy alcohol use, and don't have other conditions that limit exercise (like severe lung disease, uncontrolled high blood pressure, or recent heart attack).
- You don't have Type 1 diabetes and haven't started a GLP-1 medication within the last 6 months.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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