Clinical trials · California
HIV clinical trials in California
We’re tracking 67 recruiting hiv studies with a site in California — including Early Phase 1, Phase 1, Phase 1/Phase 2, Phase 2, Phase 2/Phase 3 and Phase 4 studies, each written for real people, not researchers.
Recruiting studies in California
- NCT01161199Recruiting
Leukapheresis study in people living with HIV
This trial uses a special blood-filtering procedure (leukapheresis) along with blood tests to better understand how HIV affects the body. It may help researchers learn more about HIV “pathogenesis,” which means what drives disease in different people.
San Francisco, CaliforniaAges 18 years+ - NCT06517693RecruitingPhase 1
HIV antibody safety study for newborns at risk
This study tests whether giving a combination of two lab-made antibodies (PGT121.414.LS and VRC07-523LS) to newborns exposed to HIV during pregnancy is safe and how the body processes them. It may help protect infants from getting HIV after birth.
Los Angeles, CaliforniaAges Up to 3 days - NCT07683117Recruiting
PEP/PrEP through pharmacist prescribing (PEPPI)
This study looks at how well pharmacists can provide PEP and PrEP (HIV prevention pills) using a special software called PEPPI. It aims to make it easier and faster for people to get these medicines.
Del Mar, CaliforniaAges 18 years+ - NCT07202546RecruitingPhase 2
New oral HIV drug trial for people new to treatment
This trial tests a new oral HIV medication (VH4524184) in people who have never taken HIV treatment before. It looks at how well the drug controls the virus and how safe it is.
Bakersfield, CaliforniaAges 18 years+ - NCT03684655RecruitingPhase 2
PET-MR scan study of immune activity in people with HIV
This Phase 2 study uses a special whole-body scan (PET-MR) to measure immune activity in people living with HIV. It may help researchers understand how well the immune system responds and how to better track HIV-related inflammation.
San Francisco, CaliforniaAges 18 years+ - NCT03729752RecruitingPhase 1
PET scan to study an HIV-fighting antibody in the body
This Phase 1/early study uses a special PET scan to see where an HIV-targeting antibody (VRC01) goes in the body. The study may help researchers understand how well this antibody reaches HIV-related targets, which could guide future HIV treatments or vaccines.
San Francisco, CaliforniaAges 18 years+ - NCT04648046RecruitingPhase 1/Phase 2
CAR-T cell treatment for HIV infection
This early-phase study tests whether CAR-T cells (immune cells modified to recognize HIV) can help control HIV. You may be asked to briefly pause HIV medicines to see how well the treatment controls the virus.
Sacramento, CaliforniaAges 18–65 - NCT04855773Recruiting
Mobile text-message support to help people stay on PrEP
This trial tests whether phone-based (iPhone/Android) text-message support can improve how consistently people use PrEP, an HIV prevention medicine. It may help you stay on track with refills and clinic visits, especially if you’re at higher risk of stopping PrEP.
San Francisco, CaliforniaAges 15 years+ - NCT04883255RecruitingEarly Phase 1
Study cannabis effects on brain function in adults with HIV
This early-phase study looks at how cannabis (and the body’s cannabinoid system) may affect thinking and brain-related measures in people with HIV. You may be asked to avoid cannabis and complete several brain and health assessments to see how these factors relate.
San Diego, CaliforniaAges 18–65 - NCT07266831RecruitingPhase 2/Phase 3
Study of islatravir and ulonivirine for new HIV patients
This trial tests two new HIV medications, islatravir and ulonivirine, in people who have never taken HIV treatment before. It aims to see if this combination can safely control the virus.
Los Angeles, CaliforniaAges 18 years+ - NCT05241990Recruiting
Help improve alcohol care for people with HIV in clinics
This study tries a practical clinic strategy to help HIV clinics better offer and carry out alcohol treatment. You may be able to join if you work at the clinic or if you have HIV and your alcohol use screening shows possible unhealthy drinking.
San Diego, CaliforniaAges 18 years+ - NCT05514899RecruitingPhase 2
Cannabidiol and THC study for gut health and brain inflammation in HIV
This Phase 2 study tests whether cannabidiol (CBD) and tetrahydrocannabinol (THC) change the gut microbiome and brain-related inflammation in people with HIV. It may help researchers understand new ways to reduce inflammation, but you would need strict cannabis and CBD/THC avoidance during the study.
San Diego, CaliforniaAges 21–70 - NCT06055868Recruiting
HIV, oral cancer, and health equity study
This study looks at the experiences of people living with HIV who also have oral or throat cancer. The goal is to understand health disparities and improve care.
San Francisco, CaliforniaAges 18 years+ - NCT05077527RecruitingPhase 1
CAR-T treatment for HIV and aggressive B-cell lymphoma
This trial studies a lab-made immune cell treatment (CAR-T) for adults who have HIV and aggressive B-cell non-Hodgkin lymphoma that has come back or did not respond to prior treatment. It aims to see if the treatment can control the lymphoma safely in this specific group.
Duarte, CaliforniaAges 18 years+ - NCT06230367Recruiting
Text program for HIV prevention for young guys who like guys
This trial tests a text-messaging program to help young guys who have sex with guys stay HIV-negative. It's designed for teens and young adults who own a cell phone and can take a quick HIV test at home.
San Clemente, CaliforniaAges 13–22 - NCT06796686RecruitingPhase 1
HIV vaccine safety and immune response study for healthy adults
This trial tests a new two-part HIV vaccine regimen in healthy adults without HIV. The goal is to see if it is safe and produces an immune response that could help prevent HIV.
San Francisco, CaliforniaAges 18–55 - NCT06856174RecruitingPhase 4
Menopause Hormone Therapy for Women with HIV
This trial tests whether hormone therapy can help manage hot flashes and night sweats in women living with HIV who are going through menopause. It's designed to see if this treatment is safe and effective for this group.
Los Angeles, CaliforniaAges 40–60 - NCT07143968RecruitingPhase 2
Resmetirom for people with MASLD and HIV
This study tests if resmetirom can help people who have both HIV and a liver condition called MASLD (fat buildup in the liver not caused by alcohol). You may qualify if your liver has a certain amount of fat and stiffness, and your HIV is well controlled with stable medication.
La Jolla, CaliforniaAges 18 years+ - NCT07284082Recruiting
How Does Menopause and HIV Affect Heart Health in Women?
This study looks at how menopause and HIV together might affect a woman's risk for heart disease. If you are a woman with HIV and are either premenopausal, perimenopausal, or postmenopausal, the researchers want to see if the combination of HIV and menopause creates a higher risk.
San Francisco, CaliforniaAges 18 years+ - NCT06488846Enrolling by invitation
Giving HIV injections at home with a helper
This study tests whether having a trained friend or family member give you your HIV injections at home is safe and works as well as getting them at a clinic. You may qualify if you are already on the injectable HIV medication cabotegravir/rilpivirine (Cabenuva) and have a support person willing to help.
San Francisco, CaliforniaAges 18 years+ - NCT06388109Recruiting
Lifesaving support app for HIV care
This trial tests a mobile app designed to help people living with HIV stay engaged in their care. If you are newly diagnosed, have missed appointments, or have had trouble keeping your viral load suppressed, this app could provide the support you need to stay healthy.
Van Nuys, CaliforniaAges 13–34 - NCT07040319RecruitingPhase 1/Phase 2
Hepatitis C treatment study for pregnant women
This study tests a medicine called glecaprevir/pibrentasvir for pregnant women with hepatitis C, with or without HIV. It aims to see how the medicine works in the body and if it is safe during pregnancy.
Los Angeles, CaliforniaAges 16–45 - NCT03174977RecruitingEarly Phase 1
How HIV medicine moves through the body on MRI scans
This early study measures how raltegravir (an HIV medicine) spreads in the body using a special scan called PET/MR. It may help doctors better understand how to deliver and monitor HIV treatment, even though it focuses on measuring drug behavior rather than curing HIV.
San Francisco, CaliforniaAges 18 years+ - NCT01336855Recruiting
Provide blood for studies comparing HIV groups
This study collects blood to help researchers run multiple projects, including comparing people who are HIV-negative with people who have HIV. It may help advance knowledge that could improve future testing or treatments.
San Francisco, CaliforniaAges 18 years+
HIV trials by city in California
Where these studies are running in California
Institutions with a site for the recruiting hiv studies listed above.
- University of California, San Francisco · 7 studies
- Zuckerberg San Francisco General Hospital and Trauma Center · 3 studies
- San Francisco Department of Public Health · 2 studies
- University of California San Diego · 2 studies
- University of California, Los Angeles (UCLA) · 2 studies
- Altman Clinical and Translational Research Institute
- Center for Innovative Public Health Research
- City of Hope Comprehensive Cancer Center
What taking part in a hiv study involves
A screening visit first
Before anything else, the study team checks whether you fit — usually a visit with some tests. You can stop at any point, and screening is typically free.
Care at a nearby site
Study visits happen at a clinic or hospital taking part. Many studies cover the cost of the study treatment and related visits, and some reimburse travel.
You stay in control
Taking part is voluntary and you can leave a study at any time, for any reason, without affecting your regular care.
The team decides eligibility
Our fit check is a helpful first read, not a decision. The study team makes the final call after reviewing your health history.
HIV trials in other states
Common questions
- Are there hiv clinical trials in California?
- Yes. We're currently tracking 67 recruiting hiv studies with a site in California, each rewritten in plain language so you can see what it's testing and who it's for.
- How do I find out if I qualify for a hiv study in California?
- Each study lists its eligibility rules — age, diagnosis, prior treatments. On every trial page we explain these in plain language and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Do I have to live in California to take part?
- Not necessarily. These studies have a site in California, but eligibility is about your health, not your address — some people travel to take part, and a few studies reimburse travel. The study team can tell you what's required.
- Does it cost anything to join a hiv trial?
- Using Clin2 is always free. Many trials cover the study treatment and related visits; some reimburse travel. The study team explains exactly what's covered before you decide.
Not the right time?
New hiv studies open in California regularly. Set up a health profile and we’ll quietly watch for studies that fit you and email you when one opens.
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.