Immunity clinical trials

Studying Immune System Disorders and Family Genetics

This research study examines how the immune system malfunctions in patients with common variable immunodeficiency (CVID)—a condition where the body doesn't make enough antibodies to fight infections. Researchers want to understand the genetics and immune patterns to help develop better treatments. Family members may also be asked to participate to help identify genetic causes.

Study immune system problems in people with unusual infections

This study looks at how the immune system works in people who have abnormal immune function, often shown by unusual or repeated infections or long-lasting inflammation. It may involve tests using blood samples and storage of blood for future research.

BBD-1 immune therapy for IgA vasculitis

This trial tests a new drug called BBD-1 that may help treat IgA vasculitis, a condition where your immune system attacks small blood vessels, causing a purple rash and organ damage. The study measures how well BBD-1 reduces symptoms and side effects.

Probiotic supplement for gut health in healthy adults

This trial tests a daily probiotic supplement's effect on digestion, immune health, and overall well-being. If you're a healthy adult, you may help discover if this product can make you feel better day-to-day.

Testing a supplement for preventing colds

This trial tests whether a daily supplement called Immune X can help prevent colds in healthy adults. If you often get colds and are in good health, you might be able to join.

Sequential combination therapy for newly diagnosed ITP in adults

This study tests a combination of multiple drugs given in sequence to adults with newly diagnosed immune thrombocytopenia (ITP), a condition of low platelets. The goal is to see if this approach improves platelet counts and is safe.

Study of ACI-19764 for healthy people and those with heart risks

This trial tests an experimental drug called ACI-19764 to see how safe it is, how the body handles it, and how it affects the immune system. It's for healthy adults and for adults with heart-related risk factors like obesity or type 2 diabetes.

Toxins, immunity, and B-cell lymphoma

This study looks at how exposure to toxins might affect your immune system if you have B-cell non-Hodgkin lymphoma. You'll provide blood and skin samples, plus have your genes sequenced, to help researchers find links between environmental exposures and lymphoma.

Peanuts for stress and heart health

This trial tests whether eating peanuts every day can reduce stress, improve immune function, and lower inflammation in people who feel stressed. If you are stressed and generally healthy, you may qualify.

Immune Boost Treatment After CAR-T or TCE Therapy

This study tests a new immunoglobulin (antibody) treatment called IgPro20 in adults whose immune systems became weakened after receiving CAR-T cell or TCE therapies for blood cancers. The goal is to help strengthen your immune system and reduce infection risk.

Adjuvant Immune Checkpoint Inhibitors in Postoperative Hepatocellular Carcinoma

Romiplostim plus steroids vs steroids alone for newly diagnosed ITP

This trial tests if adding romiplostim (a drug that helps make platelets) to standard steroid treatment works better than steroids alone for adults who have not been treated for ITP before. It is for people with low platelet counts and may help reduce bleeding.

Using a blood test to guide how long immunotherapy continues for advanced melanoma

This study looks at using a blood test that detects tiny pieces of cancer DNA (called ctDNA) to help decide how long patients with advanced melanoma should stay on immunotherapy. It may help some patients safely stop treatment earlier if the blood test shows the cancer is under control.

CRISPR Gene Therapy for Immune Blood Disorders

This trial tests CTX112, a new CRISPR gene therapy that modifies your immune cells to treat severe immune thrombocytopenic purpura (ITP) or warm autoimmune hemolytic anemia (WAIHA) that hasn't responded to standard treatments. The goal is to see if it's safe and can help your body stop attacking its own blood cells.

RSV and HMPV vaccine study for adults 60 and older

This study tests a new vaccine that targets two respiratory viruses, RSV and HMPV, to see if it's safe and effective in adults 60 years and older. It may help prevent serious lung infections caused by these viruses.

Gut Health and Rotavirus Vaccine Response in Adults

This study examines how the health of your digestive system affects how well your body responds to an oral rotavirus vaccine (a vaccine given by mouth to protect against rotavirus infection). You'll have two endoscopy procedures—a camera test to look inside your digestive tract—and provide samples to help researchers understand this connection.

Eggs, gut health, and metabolism study

This study looks at how eating whole eggs versus egg whites affects your gut bacteria, metabolism, and immune system. It aims to understand how eggs may influence health markers in people of different weight ranges.

Patient preferences for ITP treatment

This study looks at what patients with ITP prefer in their treatments. It may help doctors understand which treatment options matter most to patients like you.

Testing IDOV-Immune for advanced solid tumors

This trial tests an investigational drug called IDOV-Immune for people with advanced solid tumors that have stopped responding to standard treatments. The goal is to see if it is safe and effective.

Study of Long-Term Viral Brain Infections

This study follows patients with chronic viral infections affecting the brain and spinal cord. Researchers will collect spinal fluid samples and track your health over one year to better understand these infections and improve care.

Continuous temperature monitoring for cytokine release syndrome

This study tests a wearable device that continuously monitors your body temperature to detect cytokine release syndrome, a possible side effect of certain immunotherapies. The goal is to catch it early so you can get treatment faster.

A study of KAN-004 for diarrhea or colitis from immunotherapy

This trial tests a new treatment, KAN-004, for people with diarrhea or colon inflammation caused by cancer immunotherapy. It aims to help manage these side effects.

Study of pirtobrutinib in first-line CLL/SLL

This study tests a new oral medication called pirtobrutinib in people with previously untreated CLL or SLL. Researchers will collect blood and lymph node samples to understand how the immune system responds to the drug.

Decoding liver cancer immune evasion with advanced testing

This trial studies liver cancer tissue to understand how the tumor hides from the immune system. The goal is to use this knowledge to improve future treatments.