Clinical trials
Immunodeficiency clinical trials
Below are recruiting immunodeficiency clinical trials, each written for real people, not researchers. We’re tracking 123 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07284641RecruitingPhase 2
Stem cell transplant for immune disorders
This trial tests a stem cell transplant to treat common variable immunodeficiency (CVID) and other immune problems. It aims to replace a faulty immune system with a healthy one from a donor.
Pittsburgh, PennsylvaniaAges 5–40 - NCT06954441RecruitingPhase 3
A new immune therapy for people with low IgG
This trial tests a new immunoglobulin treatment (V-Immune) for people with primary IgG deficiency who are already on IVIG therapy. It aims to see if this new therapy can effectively replace their current treatment.
Recife, PernanbucoAges 2 years+ - NCT02579967RecruitingPhase 2
Stem cell transplant for primary immune system disorders
This study tests whether an allogeneic stem cell (bone marrow) transplant can correct an inherited immune problem in people with severe primary immunodeficiencies. It may help reduce life-threatening infections and improve quality of life, depending on your overall health and donor match.
Bethesda, MarylandAges 4–75 - NCT03394053Recruiting
Studying the causes of primary immunodeficiency disorders
This study looks at blood samples and genetic information from people with primary immunodeficiency (a condition where the immune system doesn't work properly), their relatives, and healthy volunteers. The goal is to learn more about what causes these disorders, which could help improve future treatments.
Washington D.C., District of ColumbiaAges 1 day–90 years - NCT07766304Recruiting
Long-term thinking and emotional health after stem cell transplant for immune disorders
This study checks how children who had a stem cell transplant for a primary immune deficiency are doing emotionally and mentally, at least 2 years after the transplant. It helps us understand the long-term effects of this treatment on children's health and development.
ParisAges 6–8 - NCT07711223RecruitingPhase 1/Phase 2
New HIV pill compared to standard treatment for untreated adults
This trial compares a new HIV medication (ACC017) to an existing one (dolutegravir) in adults who have HIV but have never taken HIV drugs before. The goal is to see if the new pill works as well and is safe.
BeijingAges 18 years+ - NCT07530198RecruitingPhase 1
HIV DNA vaccine test for people on stable treatment
This study tests a new DNA vaccine (ICVAX) designed to help your immune system better control HIV. You'll receive injections over several months if your HIV is well-controlled with current medications.
Shatin, New TerritoriesAges 18–60 - NCT06821880Recruiting
Tracking infections and quality of life in blood cancer patients
This study uses a smartphone or web app to track infections and quality of life in people with multiple myeloma or chronic lymphocytic leukemia who have a weakened immune system. The goal is to create a better screening tool for infections and understand how the disease and treatment affect daily life.
Innsbruck, TyroliaAges 18 years+ - NCT07346859RecruitingPhase 3
Study of BP-SCIG 20% for primary immune deficiency
This trial tests a new medicine (BP-SCIG 20%) given under the skin to help children and adults with primary immunodeficiency who have trouble making antibodies. It aims to see if the medicine is safe and works well to prevent infections.
CherkasyAges birth+ - NCT07255157Recruiting
Peripheral Helper T-cells in CVID
This study looks at a specific type of immune cell in people with Common Variable Immune Deficiency (CVID). It aims to learn more about how these cells behave and may help guide better treatments for this condition.
PessacAges 18 years+ - NCT07192419Enrolling by invitation
Helping Older Adults With HIV Thrive
This study looks at how to help people aging with HIV stay healthy and thrive. It is for patients 50 and older who get their HIV care at certain Indiana clinics and may offer extra support or resources.
Indianapolis, IndianaAges 50 years+ - NCT07071623RecruitingPhase 3
A study of an experimental drug to prevent HIV
This trial tests a new medication called MK-8527 to see if it can prevent HIV-1 infection in women who are at risk. If you are a cisgender woman, HIV-negative, and sexually active, this study could be an option for you.
Homabay County, Homa Bay CountyAges 16–30 - NCT06883097Recruiting
Quitting smoking with HIV: A smoking cessation trial
This study tests whether nicotine replacement therapy (like patches or gum) can help people living with HIV quit smoking. You'll be part of a program that supports your quit attempt while you receive care for HIV.
Winston-Salem, North CarolinaAges 18 years+ - NCT06851767Enrolling by invitationPhase 1/Phase 2
Gene therapy for X-linked severe combined immunodeficiency
This study tests a gene therapy to treat X-linked severe combined immunodeficiency (X-SCID) without a stem cell transplant from a matched sibling. It aims to improve immune function and reduce infections using your own stem cells modified to carry the correct gene.
Bethesda, MarylandAges 3–99 - NCT06634641RecruitingPhase 4
Clozapine and immune function in Parkinson's disease
This trial tests whether clozapine, a medication for psychosis in Parkinson's disease, affects the immune system. It involves regular blood monitoring to help keep patients safe.
SalouëlAges 18 years+ - NCT06565078Recruiting
Safety study of immune globulin for primary immunodeficiency
This study is a safety check for people with primary immunodeficiency who are already using a specific immune globulin treatment given under the skin. It looks at medical records to see if any side effects occurred.
Tokyo, TokyoAges Any age - NCT05879757Recruiting
Real-world HyQvia use for adults with myeloma and weak immunity
This study looks at how HyQvia (an immune-boosting medicine given under the skin) is used in real life for adults with multiple myeloma and secondary immune problems. It may help doctors understand what works best and how patients do when HyQvia is used routinely.
CórdobaAges 18 years+ - NCT05071222RecruitingPhase 1/Phase 2
Gene therapy trial for Artemis SCID using modified blood cells
This trial tests whether gene therapy can safely and effectively treat children with a specific type of severe combined immunodeficiency (SCID) caused by an Artemis gene problem. It uses the patient’s own stem cells, modifies them to add a missing gene, and then returns them after chemotherapy to help the new cells work.
ParisAges Up to 3.9 years - NCT04925375RecruitingPhase 2
Abatacept for children with CVID and lung scarring
This Phase 2 trial tests abatacept to improve a specific type of lung disease in children with common variable immunodeficiency (CVID). It aims to slow or reduce ongoing lung changes seen on CT scans while they continue their usual immune “replacement” therapy.
San Francisco, CaliforniaAges 4 years+ - NCT04375800RecruitingPhase 2
Doravirine for children with HIV infection and stable treatment
This Phase 2 study tests doravirine (a type of HIV medicine) in children with HIV who are about 4 weeks to under 12 years old and weigh under 45 kg. It aims to see whether this regimen can control the virus safely, and some children may continue into an extension if they benefit.
Aurora, ColoradoAges 4 weeks–11 years - NCT04339777RecruitingPhase 2
Bone marrow transplant for inherited immune system disorders
This trial studies how well a donor bone marrow (stem cell) transplant works for people with inherited immune system problems (called immune deficiencies). It’s for patients who haven’t improved with usual treatment or don’t have another good option.
Bethesda, MarylandAges 4–69 - NCT03610802Recruiting
Send blood samples to study genetic and immune differences
This study collects blood (and sometimes related samples) to learn how genes and the immune system work in people with primary immunodeficiency (PID) or in family members who may not have it. The goal is to improve understanding of rare immune conditions and help guide future care.
Bethesda, MarylandAges 1 day–99 years - NCT03690063Recruiting
Nice HIV patient health study
This study is tracking the long-term health of people living with HIV who receive care at a specific hospital clinic. It aims to better understand HIV over time.
NiceAges 18 years+ - NCT02735824Recruiting
Genetic study of immune problems in children
This study looks for new genetic causes of immune system conditions that can run in families. If you join, researchers will collect health information (and usually samples) from children with immune concerns and from close relatives for comparison.
Zurich, Canton of ZurichAges Any age
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Immunodeficiency trials by city
Studies with a site in or near these metro areas.
Immunodeficiency trials by state
Studies with a site anywhere in these states.
Common questions
- Are there clinical trials for immunodeficiency?
- Yes. Clin2 currently lists 123 recruiting immunodeficiency studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a immunodeficiency trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a immunodeficiency trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.