Clinical trials
Immunodeficiency clinical trials
Below are recruiting immunodeficiency clinical trials, each written for real people, not researchers. We’re tracking 123 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT02479698RecruitingPhase 2
Immune cells for BK or JC virus infections
This trial tests a treatment using special immune cells (called cytotoxic T lymphocytes) to fight BK or JC virus infections in people with weakened immune systems, such as cancer patients or organ transplant recipients. It may help control the virus and reduce related complications.
Houston, TexasAges Any age - NCT01306019RecruitingPhase 1/Phase 2
Gene therapy for children with severe immune deficiency (XSCID)
This trial tests a one-time gene therapy approach to help children with X-linked SCID (a serious inherited immune disorder) make better immune cells. It’s for people who don’t have a fully matched sibling donor and need long-term follow-up after treatment.
Bethesda, MarylandAges 2–50 - NCT01852370Enrolling by invitationPhase 1/Phase 2
Lung and bone marrow transplant plan for immune system disorders
This early-phase study tests a step-by-step transplant approach: first replacing the lungs, then doing a bone marrow (stem cell) transplant to treat certain immune deficiency diseases. It may help people whose immune problem has led to severe, end-stage lung disease.
Pittsburgh, PennsylvaniaAges 5–45 - NCT00895271Enrolling by invitation
Making lab cell lines from skin biopsies in immune disorders
This study creates special lab cell lines from skin (or nasal) samples from people with immune system disorders and certain family members. It’s meant to help researchers build tools to better study these conditions using patient cells.
Bethesda, MarylandAges 2–85 - NCT00055172Recruiting
Understanding Genetic Causes of Immune System Disorders
This research study investigates why some people have weak or poorly functioning immune systems. By studying you and your relatives, researchers hope to identify genetic factors that cause these conditions and eventually develop better treatments.
Bethesda, MarylandAges 6 months–99 years - NCT07775313Enrolling by invitationPhase 1/Phase 2
Gene therapy for WHIM syndrome
This trial tests a one-time gene therapy treatment for WHIM syndrome, a rare immune disorder. It aims to fix the genetic cause to improve your body's ability to fight infections. Your stem cells will be collected, edited in a lab, and given back to you after some chemotherapy to prepare your body.
Bethesda, MarylandAges 3–75 - NCT00001467Recruiting
Study of genes in immune disorders
This research looks at how inherited (genetic) changes may affect the immune system in people with immune problems. It may help by improving understanding of these conditions and, in some cases, guiding faster care for a baby after birth.
Bethesda, MarylandAges 1 day–101 years - NCT04760574Recruiting
HIV status and low testosterone in men
This study looks at whether low testosterone (often called male hypogonadism) is linked to having HIV. It compares HIV-positive men with HIV-negative men to better understand what contributes to hormone problems and how common they are.
TaipeiAges 20 years+ - NCT05651113Recruiting
Your experience during screening for SCID
This study looks at what it feels like for people to go through screening for SCID (a rare immune condition). It may help improve the screening process and support for patients and families.
LondonAges 18 years+ - NCT06248957Recruiting
Immune system study for people with hard-to-treat immune diseases
This study aims to understand the immune system in people who have immune problems or whose immune-related diseases are not helped by standard treatments. It may lead to better ways to diagnose and treat these conditions.
StockholmAges Any age - NCT07737275Recruiting
Portable x-ray screening for tuberculosis in recent migrants
This trial uses a portable x-ray machine to quickly check for tuberculosis (TB) in people who recently moved to the US. It aims to make TB screening easier and faster for migrants.
New York, New YorkAges 18 years+ - NCT07707778Enrolling by invitationPhase 4
Tirzepatide for Weight and Aging in People with HIV
This trial tests whether a weight-loss medicine called tirzepatide can slow biological aging and improve metabolism in people with HIV who are already on effective treatment. It may help you reduce weight and possibly reverse some signs of aging.
TaipeiAges 18 years+ - NCT07698197Recruiting
Exercise study for immune system problems
This study tests if a moderate exercise program can help people with certain antibody deficiencies. It aims to see if exercise improves immune function in people who are not taking immunoglobulin therapy.
Milford, ConnecticutAges 18–65 - NCT06267508Recruiting
HIV testing and treatment for newborns
This study looks at ways to test and treat newborns for HIV early to improve their long-term health. It is for mothers with HIV whose babies are less than 3 days old and who are willing to have their babies tested and followed at home.
BeiraAges 18 years+ - NCT07541131Enrolling by invitation
Reducing HIV stigma to improve treatment access for drug users
This study tests whether reducing stigma and discrimination against people who use drugs can help more people access HIV treatment and prevention. You would participate in peer-led group sessions and surveys over 18 months to help researchers understand how stigma affects treatment access in Bishkek.
BishkekAges 18 years+ - NCT07497594Recruiting
Twice-yearly shots to prevent HIV
This trial tests a new HIV prevention medicine called lenacapavir, given as a shot every six months. It's for young people at risk of HIV who haven't used PrEP before or have had gaps in their PrEP use.
Manaus, AmazonasAges 16–30 - NCT07495059Recruiting
HIV prevention and care study for transgender women
This trial tests an adapted approach to improve HIV prevention and care for transgender women in Ho Chi Minh City. It aims to help participants stay healthy and access services.
Ho Chi Minh CityAges 16 years+ - NCT07476339RecruitingPhase 4
Returning to HIV Care with Biktarvy
This trial tests the medication Biktarvy (bictegravir, emtricitabine, and tenofovir alafenamide) for people with HIV who have stopped taking their antiretroviral therapy (ART) for at least 12 weeks and are ready to restart treatment. It aims to see how well the medication works when restarting care.
Clearwater, FloridaAges 18 years+ - NCT07461350Enrolling by invitation
Heart health study in people with and without HIV
This study uses MRI scans to look at how stimulant use and inflammation affect the heart in people with and without HIV. It aims to learn more about heart disease risks and may help guide future care.
San Francisco, CaliforniaAges 30 years+ - NCT06424964Recruiting
HIV treatment study for injectable cabotegravir/rilpivirine in Belgium
This study looks at people in Belgium who have already received at least one dose of a long-acting injectable HIV medication called cabotegravir/rilpivirine. The goal is to learn more about how this treatment works in real-world settings.
BrusselsAges 18–99 - NCT07418385Recruiting
Voluntary HIV testing for adults in France
This study offers free, voluntary HIV testing to anyone in France who is 18 or older. It aims to make HIV screening easy and accessible, regardless of your sexual history or past testing.
ReimsAges 18 years+ - NCT07406217RecruitingPhase 2
Optimizing antivirals for immunocompromised COVID-19 patients
This trial tests whether an optimized antiviral treatment can help people with weakened immune systems who have COVID-19. It aims to find the best way to treat them to prevent severe illness.
Basel, BaselAges 16 years+ - NCT07370649Recruiting
Long-acting HIV injectable study for subtype A6
This study looks back at medical records of people with HIV-1 who have received a long-acting injectable treatment called cabotegravir plus rilpivirine. It aims to see how well this treatment works for people with a specific HIV subtype (A6).
PragueAges 18 years+ - NCT07336797RecruitingPhase 2
Empagliflozin for weight and metabolism in HIV
This trial tests if empagliflozin, a diabetes medicine, can improve weight and metabolism in people with HIV who take dolutegravir and have a high body mass index (BMI). It may help reduce weight gain linked to HIV treatment.
CairoAges 18–65
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Common questions
- Are there clinical trials for immunodeficiency?
- Yes. Clin2 currently lists 123 recruiting immunodeficiency studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a immunodeficiency trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a immunodeficiency trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.