Clinical trials
Irritability clinical trials
Below are recruiting irritability clinical trials, each written for real people, not researchers. We’re tracking 141 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06690398RecruitingPhase 3
Study of Lumateperone for Autism-Related Irritability in Teens
This study tests a new medication called Lumateperone to see if it can reduce irritability in children and teens with autism. It's a 3-month trial that compares the study drug to a placebo (a pill with no active medicine) to find out if it helps with mood and behavior.
Dothan, AlabamaAges 5–17 - NCT06668922Recruiting
Diet and irritable bowel syndrome study
This study compares how people with and without irritable bowel syndrome (IBS) react to different foods. It may help find which foods trigger symptoms and which are safe to eat.
Los Angeles, CaliforniaAges 18–75 - NCT06413004Recruiting
IBS and immune reactions to bacteria in the gut
This study tests whether some IBS symptoms are linked to a certain gut bacteria and an immune reaction. It aims to understand the cause of IBS to find better treatments.
GothenburgAges 18–70 - NCT06291038Recruiting
Glutamine for IBS with leaky gut
This trial tests whether a supplement called glutamine can help people with irritable bowel syndrome (IBS) who have increased gut permeability (leaky gut). It aims to see if taking glutamine improves digestive symptoms and quality of life.
AmiensAges 18–75 - NCT06020261Recruiting
Parent training for kids with irritability
This study tests if a parent management training program can help reduce irritability in children. You and your child will work together with a therapist to learn new ways to handle challenging behaviors.
Aurora, ColoradoAges 10–14 - NCT05740319Recruiting
Test stool transplant to treat irritable bowel syndrome
This trial studies fecal microbiota transplantation, which is transferring stool bacteria from a healthy donor to help rebalance gut microbes. If you have irritable bowel syndrome (IBS) that hasn’t improved after several standard treatments, this study may see whether it reduces your symptoms and is safe.
Shanghai, Shanghai MunicipalityAges 18–70 - NCT05730491Recruiting
Online parenting program for kids with IBS-related belly pain
This trial tests an online social learning program to help parents support their child when the parent has irritable bowel syndrome (IBS) or related belly pain. It may help families build coping skills and resilience through guided parent sessions.
Seattle, WashingtonAges 18 years+ - NCT05680766Recruiting
Exercise training to improve IBS symptoms in inactive people
This trial tests whether a structured exercise program can improve symptoms in people with irritable bowel syndrome (IBS) who currently live a mostly sedentary, inactive lifestyle. It focuses on safety and feasibility (whether the program can be done and what symptom changes may occur).
JetteAges 18–60 - NCT04880876Enrolling by invitationPhase 3
Oral IBS-D medicine trial for kids and teens
This trial tests whether an oral medicine (eluxadoline) can help children and teens with IBS-D, a condition that causes stomach pain and frequent loose stools. It’s a Phase 3 study, meaning it’s designed to confirm benefits and safety.
Corona, CaliforniaAges 6–17 - NCT02531893Recruiting
Therapy for youth with severe, frequent irritability
This study tests whether two structured therapies can reduce severe irritability and angry reactions in children and teens. It focuses on youth who have had long-lasting, frequent outbursts and trouble responding to negative emotions.
Bethesda, MarylandAges 8–17 - NCT05972317Recruiting
Personalized diet vs low FODMAP diet for irritable bowel syndrome
This study compares two diet plans for people with irritable bowel syndrome (IBS): a personalized diet tailored to your specific triggers and the low FODMAP diet, which avoids certain carbohydrates that can cause gas and bloating. The goal is to see which approach works better for relieving symptoms.
RehovotAges 18–70 - NCT07424404RecruitingPhase 3
Long-term safety study of a medication for psychiatric disorders in children and teens
This study tests a combination medicine (xanomeline and trospium chloride) to see if it is safe and tolerable over a longer period for children and adolescents with psychiatric disorders, especially those with autism-related irritability. It may help families understand if this treatment can be used beyond the initial study period.
Dothan, AlabamaAges 5–17 - NCT05185609Recruiting
Tests anal function in people with inflammatory bowel disease
This study checks how well the anal area works in people with inflammatory bowel disease (IBD), even when your bowel disease is “in remission” but you may still have symptoms. It may help doctors better understand the cause of ongoing problems and guide future care.
ÖrebroAges 18–65 - NCT05652621Recruiting
Probiotics for people with ulcerative colitis symptoms
This study looks at whether probiotic pellets help people with inflammatory bowel disease, specifically ulcerative colitis. It may help improve gut symptoms, but the trial will test how well probiotics work for participants like you.
Xinxiang, HenanAges 18–80 - NCT07858110Recruiting
Wheat flour milling and blood sugar response
This study tests whether bread made from wheat milled in different ways affects blood sugar levels and stomach comfort. If you join, you will eat study breads for 14 days and wear a glucose monitor to track your body's response.
Bergen, VestlandAges 20–40 - NCT06215222Recruiting
Studying gut bacteria in IBS and digestive issues
This study uses a tiny capsule to collect samples from your small intestine to learn about gut bacteria in people with IBS or other functional gut disorders. It could help researchers understand what causes digestive symptoms.
Redwood City, CaliforniaAges 18–70 - NCT07794150RecruitingPhase 1
Skin response study of an estradiol and levonorgestrel patch in healthy postmenopausal women
This study tests a new skin patch that releases two hormones (estradiol and levonorgestrel) to see how it affects the skin. It is for healthy postmenopausal women and checks for any irritation or allergic reactions.
Las Vegas, NevadaAges 40–75 - NCT07793487Enrolling by invitation
Testing a special dairy drink for gut and metabolic health
This study tests whether a special dairy product can help improve symptoms in people with irritable bowel syndrome or early signs of metabolic syndrome. Participants must be at a healthy weight and not have other major health conditions or be on certain diets.
WarsawAges 18 years+ - NCT07783516Recruiting
Brazilian Jiu-Jitsu for trauma relief in first responders
This study tests whether Brazilian Jiu-Jitsu classes, taken twice a week, can help first responders cope with trauma-related stress. You'll learn self-defense and mindfulness while tracking your stress levels.
Conroe, TexasAges 18 years+ - NCT04014413Recruiting
Fecal transplant for gut and immune-related conditions
This trial studies whether fecal microbiota transplantation (FMT)—a medical procedure using stool from a screened donor to restore gut bacteria—can improve safety and outcomes for people with certain bowel, immune, and metabolic conditions. It may help if your symptoms are thought to be related to an unhealthy gut microbiome, though eligibility is broad and depends on specific safety factors.
Hong Kong, ShatinAges Any age - NCT07750535Recruiting
Liver fat and scarring in wheat-sensitive patients
This study looks at whether people with non-celiac wheat sensitivity or other digestive conditions have more fat in their liver or liver scarring. It aims to understand if wheat-related issues are linked to liver health.
Palermo, PalermoAges 18–65 - NCT07749092Recruiting
Kimchi powder for gut health in IBS
This study tests whether taking kimchi powder (a dried form of the fermented cabbage dish) can improve gut health and symptoms in people with diarrhea-predominant IBS. You'll avoid regular kimchi for about 2 months, then take the powder daily and track how you feel.
YangsanAges 20–70 - NCT07688044Recruiting
How food and bacteria cause belly pain in IBS
This study looks at how certain foods and gut bacteria might trigger abdominal pain in people with Irritable Bowel Syndrome (IBS). If you have IBS and frequent belly pain, you may help researchers understand the link between diet, bacteria, and pain.
Kingston, OntarioAges 18–70 - NCT06665867Recruiting
Video Follow-Up for Kids With Stomach Pain
This trial tests whether video consultations (video calls) are a good option for follow-up appointments in children with functional abdominal pain disorders. It aims to make check-ups easier for families.
AmsterdamAges 4–17
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Common questions
- Are there clinical trials for irritability?
- Yes. Clin2 currently lists 141 recruiting irritability studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a irritability trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a irritability trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.