Clinical trials
Irritability clinical trials
Below are recruiting irritability clinical trials, each written for real people, not researchers. We’re tracking 151 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07103772Enrolling by invitation
Does a food supplement help irritable bowel syndrome?
This study tests a special food-based supplement (called a nutraceutical) to see if it helps relieve symptoms of irritable bowel syndrome (IBS), like diarrhea and constipation. It is only open to UANL employees and their beneficiaries who are not already on medication for their stomach issues.
Monterrey, Nuevo LeónAges 18 years+ - NCT06837064Enrolling by invitation
Can a chatbot help manage Irritable Bowel Syndrome?
This study tests whether a chatbot can help adults with Irritable Bowel Syndrome (IBS) manage their symptoms. If you have been diagnosed with IBS, you may be able to join and use the chatbot as part of your care.
MoscowAges 18 years+ - NCT06681012Recruiting
Gelsectan for irritable bowel syndrome with diarrhea
This trial tests a supplement called Gelsectan to see if it reduces diarrhea and belly pain in people with diarrhea-predominant irritable bowel syndrome (IBS-D). It may help if you have loose, urgent stools more often than not.
LeuvenAges 18–65 - NCT06960369RecruitingPhase 1
Brain stimulation and probiotics for diarrhea-predominant IBS
This trial tests whether combining a type of brain stimulation (repetitive transcranial magnetic stimulation) with a probiotic tablet can help people with diarrhea-predominant irritable bowel syndrome. It aims to improve symptoms by targeting both the brain and the gut.
Suzhou, JiangsuAges 18–70 - NCT07000383Recruiting
Gelsectan for diarrhea-predominant IBS
This trial tests if Gelsectan, a dietary supplement, can safely reduce diarrhea and abdominal pain in people with diarrhea-predominant irritable bowel syndrome (IBS-D). It may be a new option for managing your symptoms.
Ho Chi Minh City, District 5Ages 18 years+ - NCT07519395RecruitingPhase 2
Camlipixant for abdominal symptoms in IBS-D and IBS-M
This study tests whether a new drug called camlipixant can reduce belly pain and other uncomfortable symptoms in people with irritable bowel syndrome that causes diarrhea or mixed symptoms. The trial compares camlipixant to a placebo (inactive pill) to see if it works better.
Anniston, AlabamaAges 18–80 - NCT07581756Recruiting
Brain Stimulation Treatment for Diarrhea-Prone Irritable Bowel Syndrome
This trial tests whether repeated magnetic stimulation applied to the scalp (a non-invasive procedure) can reduce diarrhea and belly pain in people with diarrhea-predominant IBS. The goal is to see if this brain-based treatment can improve your symptoms.
Suzhou, JiangsuAges 18–70 - NCT06788444Recruiting
Esketamine for irritable bowel syndrome with anxiety or depression
This study tests if esketamine, a fast-acting medication, can help people with irritable bowel syndrome who also have anxiety or depression. It is given during a colonoscopy to see if it reduces your IBS symptoms.
Beijing, Beijing MunicipalityAges 18–60 - NCT07424404RecruitingPhase 3
Long-term safety trial for teens with schizophrenia or autism irritability
This trial looks at the long-term safety of KarXT, a medication for schizophrenia, and KarX-EC for irritability related to autism in teenagers. It is for teens who have already completed the main part of a previous study without serious side effects.
Dothan, AlabamaAges 5–17 - NCT06668922Recruiting
Diet and irritable bowel syndrome study
This study compares how people with and without irritable bowel syndrome (IBS) react to different foods. It may help find which foods trigger symptoms and which are safe to eat.
Los Angeles, CaliforniaAges 18–75 - NCT06612411RecruitingEarly Phase 1
Testing a probiotic for diarrhea-predominant IBS
This trial tests whether a specific probiotic (Bacillus subtilis) can help relieve symptoms in people with diarrhea-predominant irritable bowel syndrome (IBS). The study also looks at whether the probiotic works by increasing a natural chemical called hypoxanthine in the body.
NanjingAges 16–80 - NCT02531893Recruiting
Therapy for youth with severe, frequent irritability
This study tests whether two structured therapies can reduce severe irritability and angry reactions in children and teens. It focuses on youth who have had long-lasting, frequent outbursts and trouble responding to negative emotions.
Bethesda, MarylandAges 8–17 - NCT07114055RecruitingPhase 2/Phase 3
Ebastine for diarrhea-predominant IBS
This trial tests whether ebastine, an allergy medicine, can help relieve symptoms of diarrhea-predominant irritable bowel syndrome (IBS-D). If you have IBS-D and are at least 18, this study may offer a new option to manage your condition.
DhakaAges 18 years+ - NCT05528926Recruiting
Resist irritability: a trial for children with ongoing behavior issues
This trial tests a program meant to reduce long-lasting irritability in children and teens who have conditions like ADHD, oppositional behavior, disruptive behavior, mood/anxiety problems, or DMDD. It includes children whose parents rate irritability as at least moderately severe and who have had symptoms for 6 months or more.
MontpellierAges 6–15 - NCT06104631Recruiting
Testing a treatment for IBS-like symptoms in Crohn's remission
This study tests whether a new treatment can reduce IBS-like symptoms, such as belly pain and bloating, in people whose Crohn's disease is in remission. It aims to improve your quality of life without targeting active Crohn's inflammation.
LiègeAges 18–75 - NCT06020261Recruiting
Parent training for kids with irritability
This study tests if a parent management training program can help reduce irritability in children. You and your child will work together with a therapist to learn new ways to handle challenging behaviors.
Aurora, ColoradoAges 10–14 - NCT03687814Recruiting
Low FODMAP diet plus PEG for IBS with constipation
This study tests whether a low-FODMAP diet combined with PEG 3350 can reduce symptoms in adults with IBS-C (irritable bowel syndrome with constipation). It may help improve bowel habits and abdominal pain, and it checks which people can safely follow the diet and treatment plan.
Ann Arbor, MichiganAges 18 years+ - NCT06706674RecruitingPhase 3
Testing lumateperone for irritability in teens with autism
This study tests an investigational medication called lumateperone to see if it can reduce irritability in children and teens with autism. It is for teenagers aged 13–17 whose irritability is causing significant problems.
Little Rock, ArkansasAges 5–17 - NCT06737666RecruitingPhase 1
Tong-Xie-Yao-Fang for Diarrhea-Predominant IBS
This trial tests an herbal formula called Tong-Xie-Yao-Fang for people with diarrhea-predominant irritable bowel syndrome (IBS-D). It aims to see if the treatment helps symptoms and how it works. Healthy volunteers are also needed for comparison.
Beijing, Beijing MunicipalityAges 18–70 - NCT06690398RecruitingPhase 3
Study of Lumateperone for Autism-Related Irritability in Teens
This study tests a new medication called Lumateperone to see if it can reduce irritability in children and teens with autism. It's a 3-month trial that compares the study drug to a placebo (a pill with no active medicine) to find out if it helps with mood and behavior.
Dothan, AlabamaAges 5–17 - NCT06801184Recruiting
Gut bacteria study for constipation-predominant IBS with methane
This study looks at the gut bacteria in people with irritable bowel syndrome (IBS) who have constipation and produce high levels of methane gas. It aims to understand how methane relates to symptoms and may guide future treatments.
LyonAges 18 years+ - NCT03339128RecruitingPhase 2
Eluxadoline for diarrhea-predominant IBS in children
This trial tests whether eluxadoline can reduce symptoms of IBS with diarrhea (IBS-D) in children ages 6 to 17. It also asks families to track symptoms with a daily diary to measure whether treatment helps over the study period.
Hot Springs, ArkansasAges 6–17 - NCT03613545RecruitingPhase 2/Phase 3
Fecal transplant to treat irritable bowel syndrome
This study tests whether transferring stool bacteria from a healthy donor (fecal microbiota transplantation) can improve symptoms of irritable bowel syndrome (IBS). It may help by changing the gut bacteria that can influence digestion and gut discomfort.
Guangzhou, GuangdongAges 18–75 - NCT04217733RecruitingPhase 3
Ethosuximide plus pentoxifylline for IBS belly pain
This Phase 3 study tests whether two medicines (ethosuximide and pentoxifylline) can reduce belly pain from irritable bowel syndrome (IBS). It may help people whose IBS pain has been moderate to severe recently and who can keep their current IBS treatment steady.
TantaAges 18 years+
Hear when a new Irritability trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.
Irritability trials by city
Studies with a site in or near these metro areas.
Irritability trials by state
Studies with a site anywhere in these states.
Common questions
- Are there clinical trials for irritability?
- Yes. Clin2 currently lists 151 recruiting irritability studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a irritability trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a irritability trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.