Clinical trials
Irritability clinical trials
Below are recruiting irritability clinical trials, each written for real people, not researchers. We’re tracking 147 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06484088RecruitingEarly Phase 1
Brain scanning study of frustration in healthy adults
This study looks at how the brain handles frustration in healthy adults using a special brain scanner called magnetoencephalography (MEG). It may help researchers understand normal brain responses to frustration.
Bethesda, MarylandAges 18–55 - NCT06505980Recruiting
Parent training for child behavior concerns
This trial tests a brief telehealth program to help parents manage their child's challenging behaviors. It may help if your child has elevated behavior issues and you can participate online.
Aurora, ColoradoAges 3–5 - NCT05905926Enrolling by invitationPhase 3
Tenapanor safety study for teens with constipation-predominant IBS
This trial checks the safety of tenapanor in children and teens (ages 6 to under 18) with IBS-C. It is only for people who finished a previous related study and agreed to continue follow-up.
Foley, AlabamaAges 6–18 - NCT06247046RecruitingPhase 3
Probiotic powder for IBS-D (SK08) trial
This study tests a new probiotic powder (SK08) to see if it reduces belly pain and diarrhea in people with IBS-D (irritable bowel syndrome with diarrhea). It lasts several months and involves taking the study powder twice a day.
Wuxi, JiangsuAges 18–70 - NCT07676253Recruiting
Helichrysum cream for skin irritation in healthy volunteers
This trial tests a cream made from an herb called Helichrysum italicum (sometimes called 'curry plant') to see if it can help soothe skin irritation caused by contact with irritants. Researchers want to see if it reduces redness and discomfort in healthy volunteers.
SplitAges 18–50 - NCT07688044Recruiting
How food and bacteria cause belly pain in IBS
This study looks at how certain foods and gut bacteria might trigger abdominal pain in people with Irritable Bowel Syndrome (IBS). If you have IBS and frequent belly pain, you may help researchers understand the link between diet, bacteria, and pain.
Kingston, OntarioAges 18–70 - NCT04014413Recruiting
Fecal transplant for gut and immune-related conditions
This trial studies whether fecal microbiota transplantation (FMT)—a medical procedure using stool from a screened donor to restore gut bacteria—can improve safety and outcomes for people with certain bowel, immune, and metabolic conditions. It may help if your symptoms are thought to be related to an unhealthy gut microbiome, though eligibility is broad and depends on specific safety factors.
Hong Kong, ShatinAges Any age - NCT04506593Recruiting
GI Motility diagnosis registry for people with digestion movement problems
This trial is a registry, meaning it collects information about people being evaluated for problems with how the gut moves. It may help doctors better diagnose gastrointestinal motility disorders in the future.
Indianapolis, IndianaAges Any age - NCT04918329Recruiting
Digestive symptom check-in study for adults
This study follows adults with long-lasting “functional” digestive symptoms as part of routine care. It may help researchers better understand these conditions and improve how they are managed.
RouenAges 18 years+ - NCT04974593RecruitingPhase 3
Test breath testing to guide a lactose-free diet in IBS
This trial studies whether a breath test (hydrogen/methane lactose testing) can predict who with IBS will improve on a lactose-free diet. If you have moderate-to-severe IBS and regularly eat lactose-containing foods, the test result may help tailor your diet approach.
Jette, Brussels CapitalAges 18–75 - NCT05097872Recruiting
Diet trial for IBS with non-constipation symptoms
This study tests whether a specific diet plan can improve symptoms in people with IBS that is not constipation (IBS-D or IBS-M). If you qualify, you’ll complete symptom questionnaires and follow the study diet for the trial period to see if symptoms improve.
LeuvenAges 18–70 - NCT05120752RecruitingPhase 3
Low FODMAP diet trial for IBS without lactose intolerance
This trial tests whether eating a low-FODMAP diet can reduce IBS symptoms in people who do not have lactose intolerance. It aims to improve moderate-to-severe IBS symptoms by changing what kinds of carbohydrates you eat.
Jette, Brussels CapitalAges 18–75 - NCT05185609Recruiting
Tests anal function in people with inflammatory bowel disease
This study checks how well the anal area works in people with inflammatory bowel disease (IBD), even when your bowel disease is “in remission” but you may still have symptoms. It may help doctors better understand the cause of ongoing problems and guide future care.
ÖrebroAges 18–65 - NCT05274854Recruiting
Practice change study for severe unexplained gut symptoms
This study looks at a new approach to care for adults with severe, long-lasting stomach or bowel symptoms when no clear cause has been found. It may help you get more coordinated support through an integrated care clinic.
Woolloongabba, QueenslandAges 18–90 - NCT05293769Recruiting
Food diary questionnaire test for IBS and activity levels
This study checks whether a food questionnaire can reliably estimate what you eat, including certain carbs that can affect digestion (FODMAPs). It also looks at how the results relate to IBS symptoms and your self-reported physical activity.
Jette, Brussels CapitalAges 18–65 - NCT05414708Recruiting
Art therapy for veterans with PTSD symptoms
This study tests whether art therapy can improve emotional well-being in military members who have significant PTSD symptoms. You would answer questionnaires and likely take part in art-making sessions as part of the treatment being studied.
Bethesda, MarylandAges 18–64 - NCT05519683RecruitingPhase 2/Phase 3
Home electrical stimulation for constipation IBS pain
This trial tests whether a home device that uses mild skin electrical stimulation can reduce belly pain from IBS with constipation. It also checks whether the treatment is safe and helpful for symptom relief over the study period.
Ann Arbor, MichiganAges 18 years+ - NCT05525598Recruiting
Online therapy for severe body–mind symptom disorders
This trial tests an internet-based treatment program for people with moderate-to-severe functional somatic disorders (long-lasting physical symptoms linked to how the body and brain interact). It may help reduce symptoms and improve day-to-day functioning by offering structured support online.
Aarhus C, DenmarkAges 18–60 - NCT05575882Recruiting
Skin cream trial to prevent relapses in very dry eczema skin
This trial tests whether a cosmetic cream can reduce eczema flare-ups and is comfortable/safe to use on very dry, irritated, eczema-prone skin. It’s mainly for children who have had recent flare-ups and moderate eczema severity.
Ciudad Autónoma de Buenos Aire, Ciudad Autónoma de Buenos AireAges 6 months–15 years - NCT05633706Recruiting
Testing a capsule to study gut bacteria in the small intestine
This study tests the SIMBA capsule to learn how gut bacteria (dysbiosis) relate to digestive conditions. It may help researchers better understand these conditions and how the capsule can be used safely.
Calgary, AlbertaAges 18–80 - NCT05652621Recruiting
Probiotics for people with ulcerative colitis symptoms
This study looks at whether probiotic pellets help people with inflammatory bowel disease, specifically ulcerative colitis. It may help improve gut symptoms, but the trial will test how well probiotics work for participants like you.
Xinxiang, HenanAges 18–80 - NCT05754190Recruiting
Smartphone study of mood and symptoms in people with pain
This study uses a smartphone app to track daily pain and mood changes over about 4 months. It’s meant to learn patterns that could help better understand how mood and pain affect each other.
Providence, Rhode IslandAges 18 years+ - NCT05776914RecruitingPhase 2
Fecal transplant to treat moderate to severe IBS symptoms
This trial tests whether putting stool (fecal microbiota) from a donor into your bowel can improve symptoms in people with IBS who are not IBS-C. It may help by changing the gut bacteria that can influence IBS symptoms.
Rochester, MinnesotaAges 18–70 - NCT05808036Recruiting
Test a diet app for IBS symptoms using the DOMINO diet
This trial studies whether a specific diet plan delivered through a phone app (the DOMINO diet) can improve symptoms in people with irritable bowel syndrome (IBS). It may help by changing what you eat to reduce gut symptoms, compared with standard care rules in the study.
LeuvenAges 18–70
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Common questions
- Are there clinical trials for irritability?
- Yes. Clin2 currently lists 147 recruiting irritability studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a irritability trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a irritability trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.