Clinical trials
Local Anesthetic clinical trials
Below are recruiting local anesthetic clinical trials, each written for real people, not researchers. We’re tracking 39 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07450781Enrolling by invitation
How saline temperature and local anesthetics affect shoulder pain after gallbladder surgery
This trial tests whether warming the saline used during surgery or adding a numbing medicine can reduce shoulder pain after laparoscopic gallbladder removal. It also checks how these affect inflammation markers in the blood.
AlexandriaAges 18–65 - NCT07409688RecruitingPhase 4
Pain relief after gallbladder surgery: comparing two ways to give local anesthetic
This trial compares two methods of giving local anesthetic during laparoscopic gallbladder removal to see which provides better pain relief. It may help patients recover with less pain after surgery.
Rawalpindi, Punjab ProvinceAges 15–60 - NCT05271331Recruiting
Numbing injection options for back surgery pain
This trial compares two ways of numbing tissue during a planned back surgery called a laminectomy: an “ESPB block” versus numbing the wound directly. It aims to see which method works better for pain control and comfort after surgery.
Padova, VenetoAges 18 years+ - NCT06075004Recruiting
Hip pain relief study comparing two injection methods
This trial tests two ways to give pain medicine around the hip joint during surgery to see which provides better pain relief. It may help patients experience less pain after hip replacement.
Santiago, Santiago MetropolitanAges 18–80 - NCT04849455RecruitingPhase 4
Nerve-block catheters plus spinal morphine for liver surgery pain
This trial tests whether placing pain-relief catheters near the back muscle plus giving morphine into the spinal fluid can improve comfort during and after liver surgery. It may help reduce the need for stronger opioid pain medicines afterward.
San Diego, CaliforniaAges 18 years+ - NCT06945263Enrolling by invitation
Comparing two freezing methods for pain after appendix removal
This study compares two ways of numbing the belly during laparoscopic appendix removal in children. It aims to find which method gives better pain relief after surgery.
Vancouver, British ColumbiaAges 4–18 - NCT06714279RecruitingPhase 1
Pain relief methods for gallbladder surgery
This trial compares two ways to reduce pain after laparoscopic gallbladder removal: one uses a nerve block during surgery and the other uses local anesthetic inside the abdomen. The goal is to find which approach provides better pain relief.
DublinAges 18 years+ - NCT06642649Recruiting
Comparing anesthesia types to reduce opioids in hysterectomy
This study compares general anesthesia alone to two types of combined anesthesia (general plus spinal) to see which reduces the amount of opioid painkillers needed during and after a laparoscopic hysterectomy. It may help patients recover with less reliance on strong pain medications.
Bellinzona, SwitzerlandAges 18 years+ - NCT07381621Recruiting
Comparing sugar water vs. numbing shots for knee arthritis
This study compares two different types of knee injections for people with knee osteoarthritis. One injection uses a simple sugar solution (dextrose), and the other uses a standard numbing medication (local anesthetic). The goal is to see which works better for reducing pain and improving knee function.
Ankara, AltindagAges 40–65 - NCT07074730Recruiting
Anesthesia types for urethral surgery
This trial compares general anesthesia versus spinal anesthesia with local numbing medicine for penis skin graft surgery. It aims to see which method works better for pain control and recovery.
Tanta, El-GharbiaAges 21 years+ - NCT06488183Recruiting
Pain relief study for laparoscopic weight loss surgery
This study compares two ways to manage pain after laparoscopic bariatric surgery: one method involves numbing medicine placed near the surgery site, and the other uses an ultrasound-guided injection near the back. It aims to find which option works better for recovery in people with moderate to severe obesity.
AlexandriaAges 20–50 - NCT04454203RecruitingPhase 4
Local anesthetic catheter to reduce tourniquet-related blood pressure spikes
This Phase 4 trial tests whether a local anesthetic catheter placed near a nerve and artery can prevent high blood pressure caused by a tourniquet during total ankle replacement surgery. If it works, it may make recovery safer and more comfortable for some patients.
Durham, North CarolinaAges 18–75 - NCT06682416Recruiting
Does the temperature of pain relief medicine affect fever during labor?
This study tests whether using a warmer or cooler numbing medicine during an epidural changes the chance of a mother developing a fever during labor. If you are planning an epidural for vaginal delivery, this trial may help improve pain relief and reduce fever risk.
Suzhou, JiangsuAges 18 years+ - NCT06694714RecruitingPhase 4
Testing how long numbing medicine lasts on the nose
This study tests two different numbing medicines on the sides of the nose to see how long each lasts and which works better.
New York, New YorkAges 18 years+ - NCT07601750Enrolling by invitationPhase 4
Local Anesthetic Study for Skin Cancer Surgery
This study tests local anesthetics (numbing medicines) used during Mohs micrographic surgery, a specialized procedure for skin cancer. Researchers want to understand how well these numbing agents work and improve patient comfort during the procedure.
Dallas, TexasAges 18–89 - NCT04880707RecruitingPhase 2
Pain medication options for lower wisdom tooth removal
This study compares pain-medication approaches during and after removing at least one lower impacted wisdom tooth (a tooth that’s stuck). It may help find a safer or more effective way to control dental pain after surgery.
Newark, New JerseyAges 18 years+ - NCT07582029Recruiting
Comparing two pain relief methods for gallbladder surgery
This study compares two ways of giving pain relief after gallbladder removal surgery: an injection of numbing medicine around the belly muscles (guided by ultrasound) versus a simple injection into the skin near the surgery cuts. The goal is to see which method provides better pain control and comfort after surgery.
IstanbulAges 18 years+ - NCT06746168Recruiting
Better pain control after knee replacement surgery
This study tests a new way to manage pain after total knee replacement. It aims to see if a specific local pain block can reduce the need for strong opioids and improve recovery.
Hasselt, LimburgAges 18–85 - NCT06602349Recruiting
Lidocaine injection for chronic anal/perineal pain
This trial tests whether injecting a numbing medicine (lidocaine) into the painful area helps people with chronic, unexplained pain in the anal or perineal region. It is for patients who have not gotten relief from standard treatments and whose MRI shows no other cause.
Paris, Île-de-France RegionAges 18 years+ - NCT07463274Enrolling by invitation
Simulation training for managing numbing medicine toxicity in surgical residents
This trial tests a simulation training program to help surgical residents (non-anesthesiologists) recognize and manage a rare but serious reaction to numbing medicine called local anesthetic systemic toxicity. Participation involves a team practice session to improve emergency readiness.
KonyaAges 18–40 - NCT07331129Recruiting
Nerve block for pain relief in groin lymph node surgery
This trial tests a special ultrasound-guided nerve block to reduce pain during and after groin lymph node removal. It may help patients undergoing this type of cancer surgery have less pain and use fewer painkillers.
CairoAges 18–65 - NCT07301476Recruiting
Testing numbing medicine spread in a knee block
This trial checks how a numbing medicine moves during a common knee block for surgery. It may help doctors improve pain control after knee operations.
Boulogne-BillancourtAges 18 years+ - NCT07146685RecruitingPhase 4
Testing different strengths of numbing medicine for shoulder replacement
This study compares two different strengths of local anesthetic used in a nerve block for shoulder replacement surgery. The goal is to see if one strength helps reduce pain that can come back as the block wears off.
Charlottesville, VirginiaAges 18 years+ - NCT07113080RecruitingPhase 4
Do Lemongrass and Lavender Help Kids With Dental Shots?
This study tests whether smelling lemongrass and lavender scents can help reduce fear and pain when a child gets a numbing shot at the dentist. It is for children ages 7 to 11 who are healthy and have never been to the dentist before.
Cairo, Cairo GovernorateAges 7–11
Hear when a new Local Anesthetic trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.
Common questions
- Are there clinical trials for local anesthetic?
- Yes. Clin2 currently lists 39 recruiting local anesthetic studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a local anesthetic trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a local anesthetic trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.