Clinical trials
Local Anesthetic clinical trials
Below are recruiting local anesthetic clinical trials, each written for real people, not researchers. We’re tracking 43 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07409688RecruitingPhase 4
Pain relief after gallbladder surgery: comparing two ways to give local anesthetic
This trial compares two methods of giving local anesthetic during laparoscopic gallbladder removal to see which provides better pain relief. It may help patients recover with less pain after surgery.
Rawalpindi, Punjab ProvinceAges 15–60 - NCT07450781Enrolling by invitation
How saline temperature and local anesthetics affect shoulder pain after gallbladder surgery
This trial tests whether warming the saline used during surgery or adding a numbing medicine can reduce shoulder pain after laparoscopic gallbladder removal. It also checks how these affect inflammation markers in the blood.
AlexandriaAges 18–65 - NCT04990713Recruiting
Compare two pain-blocking methods during lung surgery
This study tests two different ways of numbing the chest to reduce pain during video-assisted lung surgery (VATS). It may help some people have less pain after surgery while still allowing the surgeon to do the operation safely.
London, OntairoAges 18 years+ - NCT05271331Recruiting
Numbing injection options for back surgery pain
This trial compares two ways of numbing tissue during a planned back surgery called a laminectomy: an “ESPB block” versus numbing the wound directly. It aims to see which method works better for pain control and comfort after surgery.
Padova, VenetoAges 18 years+ - NCT06075004Recruiting
Hip pain relief study comparing two injection methods
This trial tests two ways to give pain medicine around the hip joint during surgery to see which provides better pain relief. It may help patients experience less pain after hip replacement.
Santiago, Santiago MetropolitanAges 18–80 - NCT04849455RecruitingPhase 4
Nerve-block catheters plus spinal morphine for liver surgery pain
This trial tests whether placing pain-relief catheters near the back muscle plus giving morphine into the spinal fluid can improve comfort during and after liver surgery. It may help reduce the need for stronger opioid pain medicines afterward.
San Diego, CaliforniaAges 18 years+ - NCT06945263Enrolling by invitation
Comparing two freezing methods for pain after appendix removal
This study compares two ways of numbing the belly during laparoscopic appendix removal in children. It aims to find which method gives better pain relief after surgery.
Vancouver, British ColumbiaAges 4–18 - NCT06714279RecruitingPhase 1
Pain relief methods for gallbladder surgery
This trial compares two ways to reduce pain after laparoscopic gallbladder removal: one uses a nerve block during surgery and the other uses local anesthetic inside the abdomen. The goal is to find which approach provides better pain relief.
DublinAges 18 years+ - NCT06642649Recruiting
Comparing anesthesia types to reduce opioids in hysterectomy
This study compares general anesthesia alone to two types of combined anesthesia (general plus spinal) to see which reduces the amount of opioid painkillers needed during and after a laparoscopic hysterectomy. It may help patients recover with less reliance on strong pain medications.
Bellinzona, SwitzerlandAges 18 years+ - NCT07074730Recruiting
Anesthesia types for urethral surgery
This trial compares general anesthesia versus spinal anesthesia with local numbing medicine for penis skin graft surgery. It aims to see which method works better for pain control and recovery.
Tanta, El-GharbiaAges 21 years+ - NCT07381621Recruiting
Comparing sugar water vs. numbing shots for knee arthritis
This study compares two different types of knee injections for people with knee osteoarthritis. One injection uses a simple sugar solution (dextrose), and the other uses a standard numbing medication (local anesthetic). The goal is to see which works better for reducing pain and improving knee function.
Ankara, AltindagAges 40–65 - NCT06488183Recruiting
Pain relief study for laparoscopic weight loss surgery
This study compares two ways to manage pain after laparoscopic bariatric surgery: one method involves numbing medicine placed near the surgery site, and the other uses an ultrasound-guided injection near the back. It aims to find which option works better for recovery in people with moderate to severe obesity.
AlexandriaAges 20–50 - NCT04454203RecruitingPhase 4
Local anesthetic catheter to reduce tourniquet-related blood pressure spikes
This Phase 4 trial tests whether a local anesthetic catheter placed near a nerve and artery can prevent high blood pressure caused by a tourniquet during total ankle replacement surgery. If it works, it may make recovery safer and more comfortable for some patients.
Durham, North CarolinaAges 18–75 - NCT06682416Recruiting
Does the temperature of pain relief medicine affect fever during labor?
This study tests whether using a warmer or cooler numbing medicine during an epidural changes the chance of a mother developing a fever during labor. If you are planning an epidural for vaginal delivery, this trial may help improve pain relief and reduce fever risk.
Suzhou, JiangsuAges 18 years+ - NCT06694714RecruitingPhase 4
Testing how long numbing medicine lasts on the nose
This study tests two different numbing medicines on the sides of the nose to see how long each lasts and which works better.
New York, New YorkAges 18 years+ - NCT07601750Enrolling by invitationPhase 4
Local Anesthetic Study for Skin Cancer Surgery
This study tests local anesthetics (numbing medicines) used during Mohs micrographic surgery, a specialized procedure for skin cancer. Researchers want to understand how well these numbing agents work and improve patient comfort during the procedure.
Dallas, TexasAges 18–89 - NCT04880707RecruitingPhase 2
Pain medication options for lower wisdom tooth removal
This study compares pain-medication approaches during and after removing at least one lower impacted wisdom tooth (a tooth that’s stuck). It may help find a safer or more effective way to control dental pain after surgery.
Newark, New JerseyAges 18 years+ - NCT06746168Recruiting
Better pain control after knee replacement surgery
This study tests a new way to manage pain after total knee replacement. It aims to see if a specific local pain block can reduce the need for strong opioids and improve recovery.
Hasselt, LimburgAges 18–85 - NCT05898581Recruiting
Compare two pain block methods for hip replacement surgery
This trial studies whether one type of numbing injection (a PENG block) works better than another method (local anesthetic injected into the surgical area) to control pain during and after total hip replacement. It may help choose the best pain plan for people having a specific surgical approach.
London, OntarioAges 19 years+ - NCT06600945Recruiting
Comparing two muscle relaxants for cataract surgery
This trial tests if adding magnesium sulfate to a standard muscle relaxant (atracurium) improves local anesthesia for cataract surgery. It may help patients stay comfortable during the procedure.
MinyaAges 20–80 - NCT05969457RecruitingPhase 3
Local pain-numbing injection before surgery for hysterectomy
This Phase 3 study tests whether a preventive numbing medicine injection before a vaginal hysterectomy (using the vNOTES approach) can reduce pain afterward. It may help with comfort and recovery after surgery for non-cancer reasons.
Le HavreAges 18–70 - NCT05233462Recruiting
Compare two spinal anesthesia bupivacaine dose methods for C-sections
This trial looks at whether adjusting the dose of bupivacaine by height works better than using a standard dose for spinal anesthesia during planned C-sections. It may help improve safety and comfort by aiming for the right level of numbing effect.
CaenAges 18–45 - NCT03904888Recruiting
Robot vs standard keyhole surgery for double groin hernia
This study compares two ways of doing keyhole surgery for hernias in the groin: the usual laparoscopic approach versus a robot-assisted approach. It may help show which method is safer or more effective for people with hernias on both sides.
GhentAges 18 years+ - NCT06376058Recruiting
Comparing two numbing medicines for planned C-sections
This study compares two different numbing medicines (chloroprocaine and ropivacaine) given as a spinal injection during planned C-sections. The goal is to see which one works faster and better for pain relief during surgery.
AthensAges 18–48
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Common questions
- Are there clinical trials for local anesthetic?
- Yes. Clin2 currently lists 43 recruiting local anesthetic studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a local anesthetic trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a local anesthetic trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.