Clinical trials
Local Infiltration clinical trials
Below are recruiting local infiltration clinical trials, each written for real people, not researchers. We’re tracking 40 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06946368Recruiting
Exparel for pain after knee replacement
This study tests if a long-lasting numbing medicine called Exparel, given by the surgeon during knee replacement, helps control pain after surgery. It is for people having their first total knee replacement on one knee due to arthritis.
Cleveland, OhioAges Any age - NCT06075004Recruiting
Hip pain relief study comparing two injection methods
This trial tests two ways to give pain medicine around the hip joint during surgery to see which provides better pain relief. It may help patients experience less pain after hip replacement.
Santiago, Santiago MetropolitanAges 18–80 - NCT05271331Recruiting
Numbing injection options for back surgery pain
This trial compares two ways of numbing tissue during a planned back surgery called a laminectomy: an “ESPB block” versus numbing the wound directly. It aims to see which method works better for pain control and comfort after surgery.
Padova, VenetoAges 18 years+ - NCT07239817Recruiting
Nerve block and local anesthetic for hip replacement surgery
This study tests whether a nerve block plus local anesthetic can improve pain control during and after hip replacement surgery for a broken hip. It may help reduce the need for stronger pain medications and improve recovery.
MilanAges 18 years+ - NCT05372393Recruiting
Carpal tunnel surgery with local anesthesia, with or without nerve block
This study compares two ways of giving pain control during carpal tunnel release surgery: local anesthesia alone versus local anesthesia plus a targeted nerve block. It may help find the safest and most comfortable option for people having carpal tunnel surgery.
Kuopio, Northern SavoniaAges 18 years+ - NCT07409688RecruitingPhase 4
Pain relief after gallbladder surgery: comparing two ways to give local anesthetic
This trial compares two methods of giving local anesthetic during laparoscopic gallbladder removal to see which provides better pain relief. It may help patients recover with less pain after surgery.
Rawalpindi, Punjab ProvinceAges 15–60 - NCT07477730Recruiting
Pain Relief Options for Knee Replacement Surgery
This study compares two ways to manage pain after knee replacement surgery: local numbing medicine injected into the knee versus numbing several nerves in the leg. The goal is to find which method provides better pain control and recovery.
Toulouse, Haute-GaronneAges 18 years+ - NCT07584915Enrolling by invitationPhase 4
Pain Relief Method Comparison for Knee Replacement Surgery
This study tests a new way to deliver pain medication during and after knee replacement surgery. Researchers compare injecting a long-acting numbing medicine (EXPAREL) directly into the knee joint versus spreading it through the surgical area, to see which method works better for pain control.
Los Angeles, CaliforniaAges 18 years+ - NCT07074730Recruiting
Anesthesia types for urethral surgery
This trial compares general anesthesia versus spinal anesthesia with local numbing medicine for penis skin graft surgery. It aims to see which method works better for pain control and recovery.
Tanta, El-GharbiaAges 21 years+ - NCT06488183Recruiting
Pain relief study for laparoscopic weight loss surgery
This study compares two ways to manage pain after laparoscopic bariatric surgery: one method involves numbing medicine placed near the surgery site, and the other uses an ultrasound-guided injection near the back. It aims to find which option works better for recovery in people with moderate to severe obesity.
AlexandriaAges 20–50 - NCT06968065Recruiting
Pain control after minimally invasive heart surgery: nerve block vs wound injection
This study compares two ways to manage pain after minimally invasive heart surgery: a nerve block injection near the ribs or injecting numbing medicine into the wound. The goal is to find which method works better for reducing pain and your need for painkillers.
IstanbulAges 18–75 - NCT06123117Recruiting
Nerve block vs local painkiller for gallbladder surgery recovery
This study compares two ways of giving pain relief after gallbladder removal surgery. It tests if a nerve block (STALL) works better than injecting numbing medicine directly into the surgery site. The goal is to find which method reduces pain and the need for painkillers.
Espoo, UusimaaAges 18 years+ - NCT07824908Recruiting
Numbing medicine and pain after keyhole appendix removal
This study looks at whether the place where the appendix is taken out during keyhole surgery and the use of numbing medicine can help reduce pain after the operation. If you're having this emergency surgery, you may have less pain afterward.
Diyarbakır, KayapınarAges 18 years+ - NCT07337772Recruiting
Comparing corticosteroid doses in knee replacement pain relief injection
This study compares different doses of a corticosteroid (an anti-inflammatory medicine) injected into the knee during total knee replacement surgery. The goal is to see which dose provides the best pain relief after surgery. It is for people having their first knee replacement due to osteoarthritis.
Fuzhou, FujianAges 18–100 - NCT06737237Enrolling by invitation
Nerve block vs. local numbing for collarbone surgery
This trial compares two ways to numb the area during collarbone surgery: a nerve block (cervical plexus block) or local anesthetic injections. The goal is to see which provides better pain relief and recovery.
Marine Corps Base Camp Lejeune, North CarolinaAges 18–64 - NCT07872826Enrolling by invitationPhase 3
Study of pain relief injection after hip replacement surgery
This study tests a new pain-relief injection given during hip replacement surgery to reduce pain after the operation. The goal is to help patients recover with less discomfort and possibly reduce the need for other pain medications.
ChangshaAges 18–80 - NCT07767383RecruitingPhase 4
Improving sleep quality after knee surgery with added sedation and nerve blocks
This trial tests whether adding a calming medicine called dexmedetomidine to a nerve block around the knee can help you sleep better after arthroscopic knee surgery. It aims to find if this combination reduces sleep problems during recovery.
Nantong, JiangsuAges 18–85 - NCT07704970Recruiting
Nerve block for pain relief in robotic kidney surgery
This trial tests a special nerve block called QLESP to control pain after robotic partial kidney removal. It may reduce the need for strong pain medicines and improve recovery.
Wuhan, HubeiAges 18–80 - NCT07695987Recruiting
Nerve block for pain relief after back surgery
This trial tests a nerve block called Quadro-Iliac Plane Block to reduce pain after a single-level lumbar microdiscectomy (back surgery). The block is given before surgery and may help you need less pain medicine and recover more comfortably.
Istanbul, IstanbulAges 18–75 - NCT07458256Recruiting
Liposomal bupivacaine for pain after laparoscopic surgery
This trial tests a long-acting painkiller injected during surgery to see if it reduces pain after keyhole (laparoscopic) procedures like gallbladder removal, hernia repair, or appendix removal. It may help you need fewer opioids and recover more comfortably.
Beijing, Beijing MunicipalityAges 18–64 - NCT07442539Recruiting
Numbing medicine for pain after hemorrhoid surgery
This trial tests a long-acting numbing medicine called liposomal bupivacaine to see if it reduces pain after hemorrhoid surgery better than standard care. It may be an option for people who are otherwise healthy and scheduled for this surgery.
Beijing, Beijing MunicipalityAges 18–64 - NCT06819748Recruiting
Numbing medicine mix for less pain after gallbladder surgery
This trial tests a mixture of numbing medicines (ropivacaine cocktail) injected into the surgery area to reduce pain after gallbladder removal. It's for people having same-day laparoscopic surgery and aims to help you recover with less pain.
Chengdu, SichuanAges 18–70 - NCT07350252RecruitingPhase 4
Nerve blocks with local pain relief for knee replacement
This study tests if adding a nerve block to standard local pain relief medicine helps control pain better after knee replacement surgery. It may lead to less pain and faster recovery.
TrelleborgAges 18 years+ - NCT06911463Enrolling by invitation
Pain relief for TAVI valve procedure
This study tests two numbing injections for people having a new aortic valve placed through a leg artery (TAVI). One injection is near the hip bone, the other in the groin area. The goal is to see which one provides better pain control while keeping you awake and comfortable.
CairoAges 20 years+
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Common questions
- Are there clinical trials for local infiltration?
- Yes. Clin2 currently lists 40 recruiting local infiltration studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a local infiltration trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a local infiltration trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.