Clinical trials
Local Anesthetic clinical trials
Below are recruiting local anesthetic clinical trials, each written for real people, not researchers. We’re tracking 38 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06376058Recruiting
Comparing two numbing medicines for planned C-sections
This study compares two different numbing medicines (chloroprocaine and ropivacaine) given as a spinal injection during planned C-sections. The goal is to see which one works faster and better for pain relief during surgery.
AthensAges 18–48 - NCT06789029RecruitingPhase 4
Dexamethasone and numbing medicine for children's spine surgery
This study tests whether giving a common anti-inflammatory medicine (dexamethasone) in a different way or using a different strength of numbing medicine can reduce pain and swelling during and after spine surgery in children. It's for kids aged 11–17 who are having surgery for a curved spine that started without a known cause.
PoznanAges 10–18 - NCT05233462Recruiting
Compare two spinal anesthesia bupivacaine dose methods for C-sections
This trial looks at whether adjusting the dose of bupivacaine by height works better than using a standard dose for spinal anesthesia during planned C-sections. It may help improve safety and comfort by aiming for the right level of numbing effect.
CaenAges 18–45 - NCT06617949RecruitingEarly Phase 1
Pain Control Study for New Mothers on Opioid Medication
This study looks at better ways to manage pain after childbirth for mothers who are taking medication for opioid use disorder. It aims to find which pain control method works best and is safest for you and your baby.
Milwaukee, WisconsinAges 18–40 - NCT06559969RecruitingPhase 2/Phase 3
IV vs Epidural Pain Medicine for Open Abdominal Surgery
This trial compares two ways to manage pain after major open abdominal surgery: giving pain medicine through an IV or through an epidural combined with numbing medicine. It aims to find which method works better for patients.
Iowa City, IowaAges 18–85 - NCT06452147Recruiting
Anesthesia types for preventing confusion after hip surgery in older adults
This study looks at different ways to give anesthesia during hip surgery to help older patients think and remember better afterward. It may help prevent confusion or memory problems that sometimes happen after surgery.
Dongyang, ZhejiangAges 65 years+ - NCT06420336Recruiting
Pain relief after cleft palate surgery
This study compares two ways to manage pain after cleft palate repair surgery that uses a bone graft from the hip. The goal is to see which method provides better pain control for children and teens.
Charleston, South CarolinaAges 6–18 - NCT04979338RecruitingPhase 3
Opioid-sparing pain control for gender-affirming surgery
This Phase 3 study tests ways to manage pain during and after gender-affirming surgery while using less opioid medicine. It may help improve comfort after surgery and reduce opioid-related side effects.
Los Angeles, CaliforniaAges 18 years+ - NCT05898581Recruiting
Compare two pain block methods for hip replacement surgery
This trial studies whether one type of numbing injection (a PENG block) works better than another method (local anesthetic injected into the surgical area) to control pain during and after total hip replacement. It may help choose the best pain plan for people having a specific surgical approach.
London, OntarioAges 19 years+ - NCT06223659RecruitingPhase 2
EMLA cream for pain during lymphoscintigraphy for skin cancer
This trial tests whether EMLA cream can reduce pain from injections needed to map lymph nodes for certain skin cancers. If you are scheduled for lymphoscintigraphy and sentinel lymph node biopsy, you may be eligible.
Columbus, OhioAges 18–99 - NCT06069154Enrolling by invitation
Freezing nerves for rib fracture pain
This study tests a procedure called cryoneurolysis, which uses cold to temporarily freeze nerves near broken ribs to relieve pain. It is for adults who have 1 to 6 recently broken ribs with at least moderate pain and are already getting a nerve block injection.
La Jolla, CaliforniaAges 18 years+ - NCT05969457RecruitingPhase 3
Local pain-numbing injection before surgery for hysterectomy
This Phase 3 study tests whether a preventive numbing medicine injection before a vaginal hysterectomy (using the vNOTES approach) can reduce pain afterward. It may help with comfort and recovery after surgery for non-cancer reasons.
Le HavreAges 18–70 - NCT03904888Recruiting
Robot vs standard keyhole surgery for double groin hernia
This study compares two ways of doing keyhole surgery for hernias in the groin: the usual laparoscopic approach versus a robot-assisted approach. It may help show which method is safer or more effective for people with hernias on both sides.
GhentAges 18 years+ - NCT06946368Recruiting
Exparel for pain after knee replacement
This study tests if a long-lasting numbing medicine called Exparel, given by the surgeon during knee replacement, helps control pain after surgery. It is for people having their first total knee replacement on one knee due to arthritis.
Cleveland, OhioAges Any age
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Common questions
- Are there clinical trials for local anesthetic?
- Yes. Clin2 currently lists 38 recruiting local anesthetic studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a local anesthetic trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a local anesthetic trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.