Clinical trials
Local Anesthetic clinical trials
Below are recruiting local anesthetic clinical trials, each written for real people, not researchers. We’re tracking 43 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07338916Recruiting
Finding the Best Dose of MEV90 for Shoulder Surgery Pain Relief
This study is testing different doses of a local anesthetic called MEV90 to find the best one for numbing the nerves during shoulder surgery. It aims to improve pain control after the operation.
ProvidenciaAges 18 years+ - NCT07301476Recruiting
Testing numbing medicine spread in a knee block
This trial checks how a numbing medicine moves during a common knee block for surgery. It may help doctors improve pain control after knee operations.
Boulogne-BillancourtAges 18 years+ - NCT07017400Recruiting
Nerve block for knee replacement pain relief
This trial tests a nerve block called the sacral erector spinae plane block to see if it improves pain control after total knee replacement surgery. If you're having a knee replacement and staying in the hospital overnight, you may be able to join.
CrotoneAges 18 years+ - NCT06602349Recruiting
Lidocaine injection for chronic anal/perineal pain
This trial tests whether injecting a numbing medicine (lidocaine) into the painful area helps people with chronic, unexplained pain in the anal or perineal region. It is for patients who have not gotten relief from standard treatments and whose MRI shows no other cause.
Paris, Île-de-France RegionAges 18 years+ - NCT07331129Recruiting
Nerve block for pain relief in groin lymph node surgery
This trial tests a special ultrasound-guided nerve block to reduce pain during and after groin lymph node removal. It may help patients undergoing this type of cancer surgery have less pain and use fewer painkillers.
CairoAges 18–65 - NCT04941664Recruiting
Finding the lowest safe anesthetic dose for shoulder surgery
This trial studies how much numbing medicine is needed for an ultrasound-guided nerve block used during elective shoulder rotator cuff surgery. It may help reduce side effects while still providing good pain control.
Shatin, New TerritoriesAges 18–75 - NCT04979338RecruitingPhase 3
Opioid-sparing pain control for gender-affirming surgery
This Phase 3 study tests ways to manage pain during and after gender-affirming surgery while using less opioid medicine. It may help improve comfort after surgery and reduce opioid-related side effects.
Los Angeles, CaliforniaAges 18 years+ - NCT06223659RecruitingPhase 2
EMLA cream for pain during lymphoscintigraphy for skin cancer
This trial tests whether EMLA cream can reduce pain from injections needed to map lymph nodes for certain skin cancers. If you are scheduled for lymphoscintigraphy and sentinel lymph node biopsy, you may be eligible.
Columbus, OhioAges 18–99 - NCT06463899Recruiting
Numbing medicine tubes during bypass surgery
This study tests whether numbing medicine given through two thin tubes placed during heart surgery can help you recover faster and breathe better. It is for adults having on-pump coronary bypass who also have a lung condition or other risk factor.
ReimsAges 75 years+ - NCT06420336Recruiting
Pain relief after cleft palate surgery
This study compares two ways to manage pain after cleft palate repair surgery that uses a bone graft from the hip. The goal is to see which method provides better pain control for children and teens.
Charleston, South CarolinaAges 6–18 - NCT06559969RecruitingPhase 2/Phase 3
IV vs Epidural Pain Medicine for Open Abdominal Surgery
This trial compares two ways to manage pain after major open abdominal surgery: giving pain medicine through an IV or through an epidural combined with numbing medicine. It aims to find which method works better for patients.
Iowa City, IowaAges 18–85 - NCT06617949RecruitingEarly Phase 1
Pain Control Study for New Mothers on Opioid Medication
This study looks at better ways to manage pain after childbirth for mothers who are taking medication for opioid use disorder. It aims to find which pain control method works best and is safest for you and your baby.
Milwaukee, WisconsinAges 18–40 - NCT06789029RecruitingPhase 4
Dexamethasone and numbing medicine for children's spine surgery
This study tests whether giving a common anti-inflammatory medicine (dexamethasone) in a different way or using a different strength of numbing medicine can reduce pain and swelling during and after spine surgery in children. It's for kids aged 11–17 who are having surgery for a curved spine that started without a known cause.
PoznanAges 10–18 - NCT07113080RecruitingPhase 4
Do Lemongrass and Lavender Help Kids With Dental Shots?
This study tests whether smelling lemongrass and lavender scents can help reduce fear and pain when a child gets a numbing shot at the dentist. It is for children ages 7 to 11 who are healthy and have never been to the dentist before.
Cairo, Cairo GovernorateAges 7–11 - NCT07463274Enrolling by invitation
Simulation training for managing numbing medicine toxicity in surgical residents
This trial tests a simulation training program to help surgical residents (non-anesthesiologists) recognize and manage a rare but serious reaction to numbing medicine called local anesthetic systemic toxicity. Participation involves a team practice session to improve emergency readiness.
KonyaAges 18–40 - NCT06601413Enrolling by invitation
Nerve block for pain after laparoscopic hysterectomy
This study tests a special type of nerve block (called M-TAPA) to manage pain after a laparoscopic hysterectomy. It aims to see if this block provides better pain relief than standard care.
AnkaraAges 18–65 - NCT06069154Enrolling by invitation
Freezing nerves for rib fracture pain
This study tests a procedure called cryoneurolysis, which uses cold to temporarily freeze nerves near broken ribs to relieve pain. It is for adults who have 1 to 6 recently broken ribs with at least moderate pain and are already getting a nerve block injection.
La Jolla, CaliforniaAges 18 years+ - NCT05091905Enrolling by invitationPhase 4
Tested nerve-block pain pumps after arm or leg surgery
This trial studies whether a timed, stop-and-go pain medicine delivery works better than a steady drip after surgery. It’s done using a small catheter placed near a nerve to help control pain.
San Diego, CaliforniaAges 18 years+ - NCT06946368Recruiting
Exparel for pain after knee replacement
This study tests if a long-lasting numbing medicine called Exparel, given by the surgeon during knee replacement, helps control pain after surgery. It is for people having their first total knee replacement on one knee due to arthritis.
Cleveland, OhioAges Any age
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Common questions
- Are there clinical trials for local anesthetic?
- Yes. Clin2 currently lists 43 recruiting local anesthetic studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a local anesthetic trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a local anesthetic trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.