Clinical trials · New York
Major Depressive Disorder clinical trials in New York
We’re tracking 56 recruiting major depressive disorder studies with a site in New York — including Phase 1, Phase 1/Phase 2, Phase 2, Phase 3 and Phase 4 studies, each written for real people, not researchers.
Recruiting studies in New York
- NCT07834684Recruiting
Singula health survey for routine primary care visits
This study tests a new survey during a regular doctor's visit to see if it helps improve care. If you join, you'll answer questions on your own device.
Brentwood, New YorkAges 18 years+ - NCT07775300RecruitingPhase 3
Study of an injectable drug for major depressive disorder
This study tests an investigational drug called brenipatide for major depressive disorder. It is given as a self-injection and is being compared to a placebo to see if it helps improve depression symptoms in people who are already on standard treatment.
The Bronx, New YorkAges 18–75 - NCT07680140RecruitingPhase 4
Using biomarkers to choose depression treatment
This study uses a blood test (biomarker) to help pick the antidepressant that might work best for you. It compares two treatments—standard antidepressants and ketamine—in people with major depression who haven't gotten enough relief from one prior treatment.
New York, New YorkAges 18–70 - NCT07639606Recruiting
Mobile therapy app for mood after recent stroke
This study tests whether using a smartphone or tablet app for cognitive behavioral therapy (a type of talk therapy you do on your device) can help with anxiety and depression in the first month after a stroke. The goal is to see if this convenient, at-home approach improves how you feel during early recovery.
New York, New YorkAges 18–79 - NCT07621237RecruitingPhase 2
TNX-102 SL for Major Depressive Disorder
This study tests whether a new medication called TNX-102 SL can reduce depression symptoms better than a placebo (inactive pill). You'll take the medication daily and have regular check-ins to see how you're doing.
New York, New YorkAges 18 years+ - NCT07610473RecruitingPhase 2
Testing DT-101 as an add-on for depression
This trial tests if a new medication, DT-101, can help when added to your current depression treatment. It's for adults with recurrent depression who may need extra support.
New York, New YorkAges 18–75 - NCT07592689RecruitingPhase 3
DT120 Treatment for Major Depression
This study tests whether a new medication called DT120 can help people with moderate-to-severe depression feel better. You'd take the medication for several weeks while doctors track your mood and symptoms.
New York, New YorkAges 18–74 - NCT07573176RecruitingPhase 3
Seltorexant for Depression in Adults and Older Adults
This study tests a new medication called seltorexant as a standalone treatment for major depression. The trial is for adults and older adults who have depression that hasn't improved with other antidepressants or who haven't tried them yet.
Brooklyn, New YorkAges 18–74 - NCT07572526Recruiting
Brain Stimulation to Improve Sleep and Mood in Depression
This study tests a non-invasive brain stimulation technique called tDCS (transcranial direct current stimulation) to see if improving sleep can help reduce depression symptoms. You'll do short stimulation sessions at home and track your sleep and mood.
New York, New YorkAges 18–65 - NCT06223880RecruitingPhase 4
AXS-05 vs Bupropion to prevent depression relapse
This study tests whether a new drug called AXS-05 can prevent depression from coming back, compared to an older drug called bupropion. If you have major depression and are at risk of relapse, this trial may help you stay well.
Brooklyn, New YorkAges 18–65 - NCT07412756RecruitingPhase 3
Brenipatide for major depressive disorder
This trial tests a new medication, Brenipatide, to see if it helps people with major depression who are already on a stable treatment. You would need to inject the study drug yourself and complete questionnaires.
New York, New YorkAges 18–75 - NCT07300969RecruitingPhase 2
Testing DT-101 for adults with depression
This trial tests a new medicine called DT-101 to see if it helps people with depression. It is for adults who have had more than one depressive episode in their life.
New York, New YorkAges 18–75 - NCT07284667RecruitingPhase 2
A new medicine for depression that hasn't improved with other treatments
This trial tests a new medicine called ACP-211 in adults with major depression who have not gotten enough relief from at least two previous antidepressants. The goal is to see if it can help when other treatments have not worked well.
Brooklyn, New YorkAges 18–65 - NCT07276997RecruitingPhase 2
Study of Icalcaprant for major depressive disorder
This trial tests an oral medication called icalcaprant for adults with major depressive disorder (MDD). It aims to see if the drug can reduce depression symptoms and what side effects may occur.
New York, New YorkAges 18–65 - NCT07251491RecruitingPhase 1/Phase 2
Psilocybin for depression after spinal cord injury
This trial tests whether psilocybin (a substance found in certain mushrooms) can help treat depression in people with a spinal cord injury. You would receive the study drug in a controlled setting, and your progress would be monitored closely.
The Bronx, New YorkAges 22 years+ - NCT07196501RecruitingPhase 3
Study of a new add-on treatment for depression maintenance
This trial tests a new medication (NBI-1065845) added to your current antidepressant to see if it helps maintain improvement in depression. It is for people whose depression hasn't fully responded to their current oral antidepressant.
Glen Oaks, New YorkAges 18 years+ - NCT07161700Enrolling by invitationPhase 2
Long-term safety study of SPT-300 for major depression
This study is for people who finished the earlier BUOY-1 study of SPT-300 and want to continue treatment. It tests the long-term safety and tolerability of SPT-300 for major depressive disorder, with or without anxious distress.
Brooklyn, New YorkAges 18–66 - NCT07139834RecruitingPhase 1
Memory and mood study for depression
This study tests how a medication called memantine affects memory and mood in people with major depression who are not currently taking antidepressants. It involves MRI scans and may help find new ways to treat depression.
New York, New YorkAges 18–50 - NCT07115329RecruitingPhase 2
Testing Zelquistinel for major depression
This study tests a new oral medication called Zelquistinel (taken as a tablet) against a placebo for treating major depressive disorder. Researchers want to see if it can reduce depression symptoms, especially when other antidepressants haven't been tried or haven't worked.
Cedarhurst, New YorkAges 18–64 - NCT07111390Recruiting
Home-based light therapy for major depression
This trial tests whether a special light you can use at home can help treat major depression. It's a 60Hz light that you turn on and off repeatedly. If you're 24–65, have depression, and take a stable antidepressant, you may be able to participate.
New York, New YorkAges 24–65 - NCT06592833RecruitingPhase 2
Psilocybin with or without pimavanserin for depression
This study tests whether combining psilocybin (a psychedelic substance) with pimavanserin (a medication that may help reduce side effects) works better than psilocybin alone for treating major depressive disorder. It may help people who have not responded well to other treatments.
New York, New YorkAges 21–80 - NCT07065240RecruitingPhase 2
Study of SPT-300 for major depression with or without anxiety
This trial tests an experimental oral medication, SPT-300, for people with major depressive disorder, even if they also have mild anxiety. The goal is to see if it helps improve mood safely.
Brooklyn, New YorkAges 18–65 - NCT06966401RecruitingPhase 3
Long-term safety study of a new depression treatment
This study tests a new oral medication (NBI-1065845) added to your current antidepressant to see if it's safe and tolerable over a long period for people with depression that hasn't fully responded to treatment.
Cedarhurst, New YorkAges 18 years+ - NCT06963021RecruitingPhase 3
Study of NBI-1065845 for depression that hasn't fully responded to treatment
This trial tests an investigational drug called NBI-1065845 added to your current antidepressant. It is for people with moderate to severe depression or persistent depressive disorder who have not improved enough with oral antidepressants alone.
New York, New YorkAges 18 years+
Major Depressive Disorder trials by city in New York
Where these studies are running in New York
Institutions with a site for the recruiting major depressive disorder studies listed above.
- Adams Clinical Harlem · 3 studies
- Neurocrine Clinical Site · 3 studies
- Draig Clinical Site · 2 studies
- Integrative Clinical Trials LLC · 2 studies
- Investigator Site · 2 studies
- NYU Langone Health · 2 studies
- Seaport Investigator Site · 2 studies
- Weill Cornell Medicine · 2 studies
What taking part in a major depressive disorder study involves
A screening visit first
Before anything else, the study team checks whether you fit — usually a visit with some tests. You can stop at any point, and screening is typically free.
Care at a nearby site
Study visits happen at a clinic or hospital taking part. Many studies cover the cost of the study treatment and related visits, and some reimburse travel.
You stay in control
Taking part is voluntary and you can leave a study at any time, for any reason, without affecting your regular care.
The team decides eligibility
Our fit check is a helpful first read, not a decision. The study team makes the final call after reviewing your health history.
Major Depressive Disorder trials in other states
Common questions
- Are there major depressive disorder clinical trials in New York?
- Yes. We're currently tracking 56 recruiting major depressive disorder studies with a site in New York, each rewritten in plain language so you can see what it's testing and who it's for.
- How do I find out if I qualify for a major depressive disorder study in New York?
- Each study lists its eligibility rules — age, diagnosis, prior treatments. On every trial page we explain these in plain language and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Do I have to live in New York to take part?
- Not necessarily. These studies have a site in New York, but eligibility is about your health, not your address — some people travel to take part, and a few studies reimburse travel. The study team can tell you what's required.
- Does it cost anything to join a major depressive disorder trial?
- Using Clin2 is always free. Many trials cover the study treatment and related visits; some reimburse travel. The study team explains exactly what's covered before you decide.
Not the right time?
New major depressive disorder studies open in New York regularly. Set up a health profile and we’ll quietly watch for studies that fit you and email you when one opens.
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.