Clinical trials
Mastectomy clinical trials
Below are recruiting mastectomy clinical trials, each written for real people, not researchers. We’re tracking 123 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06711965Recruiting
Custom molds for breast reconstruction shaping
This trial tests custom 3D-printed molds to help shape breast tissue during reconstruction. It is for people who are already planning a DIEP or TRAM flap after mastectomy.
Houston, TexasAges 18 years+ - NCT07579650Recruiting
Nerve Block for Pain Relief After Breast Surgery
This trial tests a special numbing technique (called a serratus posterior superior intercostal plane block) to help reduce pain after mastectomy surgery. The goal is to see if this nerve block reduces the need for pain medications after your procedure.
Diyarbakır, Outside of the USAges 18–65 - NCT03730922Recruiting
Delayed vs immediate breast reconstruction after mastectomy and radiation
This study compares two timing options for rebuilding the breast after mastectomy followed by radiation: a reconstruction done later (delayed) versus one done sooner (delayed-immediate). The goal is to see which approach works better and is safer for recovery after treatment.
AabenraaAges 18 years+ - NCT04342546Recruiting
Radiation skin side-effect test after mastectomy with implant
This trial looks at a test meant to predict how likely you are to develop side effects from radiation to the chest wall after mastectomy. It is designed for people getting immediate breast reconstruction using an implant, so treatment planning may be safer and more personalized.
DijonAges 18 years+ - NCT04666961RecruitingPhase 2
Hormone therapy before surgery for extensive DCIS
This Phase 2 study tests whether taking hormone medicine before surgery can change the surgical plan and outcomes for people with extensive ductal carcinoma in situ (DCIS). It is for estrogen-receptor positive DCIS and aims to see how this “neoadjuvant” approach affects treatment decisions.
AngersAges 40 years+ - NCT04687956Recruiting
Preventing arm swelling after breast cancer lymph node surgery
This study looks at ways to prevent arm swelling (lymphedema) related to breast cancer after surgery to remove lymph nodes. It may help people who are getting axillary lymph node dissection lower the chance of long-term swelling.
SeoulAges 19 years+ - NCT04741737Recruiting
Repeat lymph node biopsy for recurrent breast cancer
This study tests whether repeating a specific lymph node biopsy (sentinel lymph node biopsy) is safe and useful in people whose breast cancer has come back in the same breast. It may help doctors better understand whether lymph nodes are involved and guide next steps after surgery.
SeoulAges 19 years+ - NCT04819542Recruiting
Compression bandages to prevent fluid pockets after breast surgery
This study tests whether compression bandages can reduce “lymphoceles,” which are fluid collections that can happen after mastectomy-type breast surgery. If you’re having this surgery, the trial may help prevent complications and improve recovery.
ToulouseAges 18 years+ - NCT04874038RecruitingPhase 3
Lidocaine infusions to prevent long-lasting pain after breast surgery
This Phase 3 study tests whether receiving lidocaine through an IV during breast surgery can lower the chance of ongoing pain afterward. If it works, it may help some people avoid chronic, surgery-related pain in the chest wall, shoulder, or arm.
Calgary, AlbertaAges 18–100 - NCT05245812Recruiting
Robotic nipple-sparing mastectomy safety and feasibility study
This trial looks at whether a robotic technique for nipple-sparing mastectomy is safe and practical to do. It may help your care team understand whether this approach works well for people who are candidates for nipple-sparing surgery.
Dallas, TexasAges 18–80 - NCT05494502Recruiting
Nerve block to reduce long-term pain after breast surgery
This trial tests whether a specific pain-numbing nerve block given during mastectomy can reduce chronic (long-lasting) pain after breast cancer surgery. It may help some people use less pain medicine later by lowering nerve-related pain after surgery.
Beijing, Beijing MunicipalityAges 18–85 - NCT05774678RecruitingPhase 3
Pre-surgery radiation options for invasive breast cancer
This trial compares two schedules of radiation given before mastectomy to see which works better for invasive breast cancer, followed by immediate breast reconstruction. It also studies tiny “biomarker” signals in tissue to learn why one radiation approach may help more.
Houston, TexasAges 18 years+ - NCT05833659Recruiting
Comparing two breast reconstruction positions after mastectomy
This trial compares two surgical techniques for breast reconstruction: placing the implant under the chest muscle versus in front of it. It may help people understand which approach works better for comfort and healing after mastectomy.
Beijing, Beijing MunicipalityAges 18–70 - NCT05899387Recruiting
Study fluid after breast surgery
This study looks at a problem called seroma, which is fluid buildup, after certain breast surgeries. It compares different situations where implants or tissue expanders are used, to better understand what to expect and how to manage it.
Augsburg, BavariaAges 18 years+ - NCT05912569Recruiting
Test a delayed sentinel lymph node biopsy during mastectomy for DCIS
This trial tests whether doing a “sentinel lymph node biopsy” later (a delayed biopsy) can help assess whether cancer has spread to lymph nodes in people having a mastectomy for DCIS. It may help avoid unnecessary aggressive treatment if lymph nodes look normal.
SeoulAges 20–75 - NCT06024187Recruiting
Cold vs. heat cutting in nipple-sparing mastectomy
This study compares two ways of cutting tissue during nipple-sparing mastectomy (breast removal with nipple preservation) followed by immediate implant reconstruction. One method uses a cold instrument, the other uses heat (electrocautery). The goal is to see which leads to better nipple survival and healing.
Guangzhou, GuangdongAges 18–75 - NCT06094257Recruiting
Study on sensation and satisfaction after mastectomy
This study looks at how people feel after mastectomy, including transgender patients and those having nipple-sparing surgery. It aims to understand sensation and satisfaction to improve future care.
Boston, MassachusettsAges 18 years+ - NCT06166953Recruiting
Smartphone education for breast reconstruction recovery
This study tests if a smartphone-based education program helps women who are recovering from breast reconstruction surgery after a mastectomy. If you are a Turkish speaker with a compatible smartphone, you may be able to join.
Ankara, ÇankayaAges 18–75 - NCT06252662RecruitingPhase 4
Comparing two numbing medicines for mastectomy nerve blocks
This study compares two types of numbing medicine given through a nerve block before a mastectomy. One is a long-acting version (liposomal bupivacaine) and the other is a standard numbing medicine combined with a sedative (bupivacaine with dexmedetomidine). The goal is to see which provides better pain relief after surgery.
Portsmouth, VirginiaAges 18 years+ - NCT06276257Recruiting
Pain block for mastectomy with immediate reconstruction
This trial tests a nerve block to reduce pain after breast removal surgery with immediate reconstruction. It may help you recover with less discomfort.
Québec, QuebecAges 18–70 - NCT06452615Recruiting
Shock wave therapy for nerve pain after mastectomy
This study tests if a treatment called extracorporeal shock wave therapy (using sound waves from outside the body) can help relieve nerve pain that some women have after a mastectomy. It may be an option if you have burning, tingling, or numbness in your chest, armpit, or upper arm that started after your surgery.
CairoAges 40–65 - NCT06505577Recruiting
Comparing Tumor Size Before and After Breast Cancer Surgery
This study compares the size of a breast tumor measured before surgery (using imaging tests like mammogram or ultrasound) with the actual size found after the tumor is removed. It helps understand how accurate preoperative measurements are for patients having breast cancer surgery.
IncheonAges 19 years+ - NCT06649890Recruiting
Testing a new irrigation solution in breast reconstruction after mastectomy
This study tests a new surgical irrigation solution (Xperience) used during breast reconstruction after double mastectomy. It aims to see if it can reduce complications and improve outcomes for people receiving implants or tissue expanders.
Chapel Hill, North CarolinaAges 18 years+ - NCT06704659Recruiting
Repeated radiation for recurrent breast cancer
This study tests giving a second round of radiation therapy to women whose breast cancer has come back in the same breast, at least 3 years after their first radiation. It may be an option for women 55 and older who have a small, local recurrence that can be removed with surgery.
HelsinkiAges 55 years+
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Common questions
- Are there clinical trials for mastectomy?
- Yes. Clin2 currently lists 123 recruiting mastectomy studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a mastectomy trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a mastectomy trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.