Clinical trials
Mastectomy clinical trials
Below are recruiting mastectomy clinical trials, each written for real people, not researchers. We’re tracking 117 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT05494502Recruiting
Nerve block to reduce long-term pain after breast surgery
This trial tests whether a specific pain-numbing nerve block given during mastectomy can reduce chronic (long-lasting) pain after breast cancer surgery. It may help some people use less pain medicine later by lowering nerve-related pain after surgery.
Beijing, Beijing MunicipalityAges 18–85 - NCT06711965Recruiting
Custom molds for breast reconstruction shaping
This trial tests custom 3D-printed molds to help shape breast tissue during reconstruction. It is for people who are already planning a DIEP or TRAM flap after mastectomy.
Houston, TexasAges 18 years+ - NCT06649890Recruiting
Testing a new irrigation solution in breast reconstruction after mastectomy
This study tests a new surgical irrigation solution (Xperience) used during breast reconstruction after double mastectomy. It aims to see if it can reduce complications and improve outcomes for people receiving implants or tissue expanders.
Chapel Hill, North CarolinaAges 18 years+ - NCT06704659Recruiting
Repeated radiation for recurrent breast cancer
This study tests giving a second round of radiation therapy to women whose breast cancer has come back in the same breast, at least 3 years after their first radiation. It may be an option for women 55 and older who have a small, local recurrence that can be removed with surgery.
HelsinkiAges 55 years+ - NCT06512259Recruiting
AlloMend tissue support in breast reconstruction after mastectomy
This study tests a special tissue support called AlloMend used during breast reconstruction after mastectomy. It helps see how well the tissue works and how patients heal.
Joliet, IllinoisAges 18 years+ - NCT06502353Recruiting
Plexaa before gender-affirming mastectomy
This trial tests a product called Plexaa, which is applied before surgery to help prepare the skin and improve healing. It is for transgender or non-binary people having a specific type of mastectomy (breast removal) for gender affirmation.
Palo Alto, CaliforniaAges 18 years+ - NCT06447532Enrolling by invitation
Machine learning to track inflammation in breast cancer
This study uses a computer program to look at blood test results from women treated for breast cancer. The goal is to see if patterns in inflammation markers can help predict outcomes.
Buenos Aires, Buenos AiresAges 18–75 - NCT06276257Recruiting
Pain block for mastectomy with immediate reconstruction
This trial tests a nerve block to reduce pain after breast removal surgery with immediate reconstruction. It may help you recover with less discomfort.
Québec, QuebecAges 18–70 - NCT06094257Recruiting
Study on sensation and satisfaction after mastectomy
This study looks at how people feel after mastectomy, including transgender patients and those having nipple-sparing surgery. It aims to understand sensation and satisfaction to improve future care.
Boston, MassachusettsAges 18 years+ - NCT06082206Recruiting
Nerve blocks to prevent long-term pain after breast cancer surgery
This study compares two types of nerve blocks (pectoral nerve block vs. paravertebral block) to see which one better prevents long-term pain after breast cancer surgery.
AsyutAges 20–65 - NCT05794321RecruitingPhase 2
IV tranexamic acid during gender-affirming chest surgery
This Phase 2 study tests whether giving tranexamic acid through a vein during gender-affirming mastectomy can safely reduce bleeding. It may help lower blood loss and related complications during surgery.
San Francisco, CaliforniaAges 18 years+ - NCT05774678RecruitingPhase 3
Pre-surgery radiation options for invasive breast cancer
This trial compares two schedules of radiation given before mastectomy to see which works better for invasive breast cancer, followed by immediate breast reconstruction. It also studies tiny “biomarker” signals in tissue to learn why one radiation approach may help more.
Houston, TexasAges 18 years+ - NCT05585710Recruiting
Study pulsed rinse during breast implant reconstruction
This trial tests whether a special “pulsed rinse” technique during implant-based breast reconstruction improves care during surgery. If you’re having immediate expander placement at the time of mastectomy, you may be eligible to try this approach under research oversight.
Birmingham, AlabamaAges 18–75 - NCT05213962Enrolling by invitation
Radiation after nipple-sparing mastectomy with implant
This study tests local and regional radiation treatment after nipple-sparing mastectomy done with an implant. It may help reduce cancer returning in the breast/nearby tissues for people whose cancer hasn’t spread to distant sites.
Goyang-si, Gyeonggi-doAges 20 years+ - NCT05245812Recruiting
Robotic nipple-sparing mastectomy safety and feasibility study
This trial looks at whether a robotic technique for nipple-sparing mastectomy is safe and practical to do. It may help your care team understand whether this approach works well for people who are candidates for nipple-sparing surgery.
Dallas, TexasAges 18–80 - NCT05072314RecruitingPhase 3
Lidocaine drip after breast surgery to improve long-term pain
This Phase 3 study tests whether a long-running lidocaine (a numbing medicine) drip given around the time of breast surgery can improve long-term post-surgery pain and recovery. It may help people who have pain after mastectomy or breast-conserving surgery.
Kingswood, New South WalesAges 18 years+ - NCT04992650Enrolling by invitation
Ultrasound imaging during breast reconstruction after mastectomy and radiation
This study uses ultrasound pictures to better understand blood flow in breast reconstruction sites after a mastectomy, when you also need radiation therapy. It may help improve how clinicians monitor and manage healing and treatment effects in this situation.
Rochester, MinnesotaAges 18 years+ - NCT04891510Recruiting
Compare fat grafting products in breast surgery
This trial compares three methods for moving your own fat into the breast during breast surgery. It may help improve how well fat grafting works and how surgeons choose the best method for you.
New York, New YorkAges 18 years+ - NCT04819542Recruiting
Compression bandages to prevent fluid pockets after breast surgery
This study tests whether compression bandages can reduce “lymphoceles,” which are fluid collections that can happen after mastectomy-type breast surgery. If you’re having this surgery, the trial may help prevent complications and improve recovery.
ToulouseAges 18 years+ - NCT04342546Recruiting
Radiation skin side-effect test after mastectomy with implant
This trial looks at a test meant to predict how likely you are to develop side effects from radiation to the chest wall after mastectomy. It is designed for people getting immediate breast reconstruction using an implant, so treatment planning may be safer and more personalized.
DijonAges 18 years+ - NCT02918474Recruiting
Decision tool for mastectomy choices in new breast cancer
This study tests a decision-making tool to help people with newly diagnosed breast cancer make choices about removing the other (opposite) breast as a preventive step. It may help you think through risks and options in a clearer, more structured way.
Houston, TexasAges 18 years+
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Common questions
- Are there clinical trials for mastectomy?
- Yes. Clin2 currently lists 117 recruiting mastectomy studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a mastectomy trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a mastectomy trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.