Clinical trials
Medications for Opioid Use Disorder clinical trials
Below are recruiting medications for opioid use disorder clinical trials, each written for real people, not researchers. We’re tracking 226 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06415994Enrolling by invitation
Placental imaging and outcomes in opioid use disorder in pregnancy
This study looks at how the placenta and baby's development may be affected when a mother takes buprenorphine or methadone for opioid use disorder during pregnancy. It aims to find better ways to monitor health and improve outcomes for both mothers and babies.
Indianapolis, IndianaAges 18–100 - NCT04173416Recruiting
Support program for young adults in opioid recovery
This study tests a structured recovery support program for adults age 18–28 who have opioid use disorder. It may help by adding extra involvement and support while you receive common long-acting opioid treatment from a medical clinic.
Baltimore, MarylandAges 18–28 - NCT04197921Recruiting
Brain-focused ultrasound for opioid addiction-related substance use
This trial studies Exablate, a non-surgical brain treatment that aims to change activity in a specific brain area involved in cravings and substance use. It is meant for people in structured opioid or substance use treatment who are currently abstaining from opioids and other illicit drugs.
Tampa, FloridaAges 18–60 - NCT04234191RecruitingPhase 2
Test faster buprenorphine/naloxone start versus usual start for opioid use disorder
This Phase 2 study compares a rapid way to start buprenorphine/naloxone versus the standard way, for people with opioid use disorder. It aims to see whether the faster start is safe and works well enough to help people begin treatment sooner.
Vancouver, British ColumbiaAges 19 years+ - NCT04354077Recruiting
Deep brain stimulation for opioid use disorder cravings
This trial studies whether deep brain stimulation (a device that delivers small electrical signals to the brain) can reduce cravings and improve symptoms in adults with opioid use disorder. You may be eligible if you have a long history of opioid dependence and have tried multiple treatment options without lasting success.
Pittsburgh, PennsylvaniaAges 22–65 - NCT04375033RecruitingPhase 4
Oral versus injection buprenorphine for opioid use disorder
This trial compares taking buprenorphine by mouth versus as an injection for opioid use disorder. It aims to see which option helps people stay on treatment and reduces opioid use over about a year.
Tuscaloosa, AlabamaAges 18 years+ - NCT04458545RecruitingPhase 1/Phase 2
Opioid vaccine study for adults with heroin or fentanyl use
This trial tests a vaccine made from parts designed to help the body respond to opioids (heroin or fentanyl). It is mainly for adults with moderate-to-severe opioid use disorder who are using opioids that match the study dosing needs and who are willing to do frequent visits over about a year.
Eatontown, New JerseyAges 18–59 - NCT04587791RecruitingEarly Phase 1
Cannabidiol (CBD) for opioid use disorder and chronic pain
This early study tests whether CBD can reduce symptoms of chronic pain in people receiving opioid maintenance treatment for opioid use disorder. It also looks at safety and whether CBD can be added without causing major problems.
West Haven, ConnecticutAges 18–70 - NCT04811014RecruitingPhase 4
Helping young adults stop opioids after an emergency visit
This study offers an engagement program for young people who tested positive for opioids and meet criteria for opioid dependence. The goal is to help participants stop opioid use safely and learn whether this approach works well in the real-world emergency setting.
Houston, TexasAges 13–17 - NCT04892251RecruitingPhase 1/Phase 2
Ketamine-assisted therapy for opioid use disorder
This trial tests whether ketamine-assisted therapy can help people with opioid use disorder, alongside standard treatment with buprenorphine. It also looks at whether you can safely take part in group mindfulness-style sessions during the study.
Salt Lake City, UtahAges 18 years+ - NCT04927143Recruiting
Using phone incentives to support substance abstinence
This study tests a smartphone app that gives changing rewards to help people avoid drug use. It targets adults in substance treatment and tries to see if incentives can improve abstinence during treatment.
Oconomowoc, WisconsinAges 18 years+ - NCT05011266RecruitingPhase 2/Phase 3
Buprenorphine plus naltrexone shot to prevent opioid relapse
This trial tests whether a combination of buprenorphine (through your care plan) and a monthly extended-release naltrexone (XR-NTX) shot can help prevent opioid relapse. It may help people who are ready to move toward a naltrexone-based relapse-prevention treatment after detox.
Rockville, MarylandAges 18–65 - NCT05027919RecruitingPhase 2
Testing ways to predict opioid withdrawal during a taper
This Phase 2 study looks at what opioid withdrawal looks like in the body and whether they can measure it in a meaningful way. You may join if you have an opioid use disorder, can show physical dependence, and are interested in tapering (gradually reducing) opioids under study care.
Baltimore, MarylandAges 18–65 - NCT05138614Recruiting
Help for people with opioid use disorder and mental health needs
This trial studies a program meant to improve treatment access and support recovery for people with opioid use disorder who also have mental health symptoms. It may help if you are new to the program or recently relapsed, or if mental health symptoms have worsened—even without a relapse.
Holyoke, MassachusettsAges 18 years+ - NCT05142267Recruiting
Study stress and opioid-risk factors in chronic low back pain
This study looks at how stress and the body’s natural opioid/cannabinoid systems may relate to risk of opioid misuse. It tests people with long-lasting low back pain to see what biological or psychological factors might increase or lower that risk.
Nashville, TennesseeAges 18 years+ - NCT05219175RecruitingPhase 2
MDMA therapy for PTSD and opioid addiction after childbirth
This Phase 2 study tests whether MDMA-assisted therapy can reduce symptoms of PTSD and help with opioid use disorder in people after childbirth. You must be on a stable, low enough dose of methadone or buprenorphine and be able to follow study rules, including therapy sessions and safety monitoring.
Albuquerque, New MexicoAges 18 years+ - NCT05450718RecruitingPhase 4
Low-dose buprenorphine start for opioid use disorder
This trial tests whether starting buprenorphine using a low-dose plan is a safe and workable way to treat opioid use disorder. You may be able to join if you are 18+, have opioid use disorder, and can follow the study medication and visits.
The Bronx, New YorkAges 18 years+ - NCT05579470Recruiting
Study opioid treatment access with staff, patients, and local leaders
This study looks at how to expand opioid addiction treatment in Central Asia by gathering survey and discussion input from people with opioid dependence, people delivering treatment, and local health leadership. It may help improve how treatment programs are set up and delivered in the future.
New Haven, ConnecticutAges 18 years+ - NCT05614661Recruiting
Postpartum support for mothers using opioid treatment
This study tests a postpartum intervention for mothers diagnosed with opioid use disorder (or receiving opioid addiction treatment) to help during the period after having a baby. You may be eligible if you have a young child and can complete the study tasks, including possible questionnaires and an MRI if needed.
Ann Arbor, MichiganAges 18–50 - NCT05729932RecruitingPhase 1
Cannabis and opioid use disorder study
This Phase 1 trial studies cannabis in people with opioid use disorder. The goal is to better understand how it may affect opioid use disorder, while monitoring safety.
Lexington, KentuckyAges 18–55 - NCT05769218Recruiting
Rapid HIV prevention and opioid treatment access for people who inject
This study helps people who inject drugs start HIV prevention (PrEP) and medication for opioid use disorder (MOUD) faster. It may reduce HIV risk and improve access to treatment, while the study checks whether the “rapid access” approach works.
Boston, MassachusettsAges 18 years+ - NCT05829655RecruitingEarly Phase 1
Measuring drug cravings in people with opioid use disorder
This study tests whether the medication suvorexant can reduce drug cravings in people with opioid use disorder. You will take either suvorexant or a placebo and have your cravings measured in a safe setting.
Baltimore, MarylandAges 18–65 - NCT05834478RecruitingPhase 3
Noninvasive vagus nerve stimulation for opioid use disorder
This trial tests whether noninvasive vagus nerve stimulation can help people with opioid use disorder during supervised withdrawal and treatment afterward. It may be considered if you can safely move to medication or behavioral care after withdrawal.
Atlanta, GeorgiaAges 18–75 - NCT05942313Recruiting
Predicting and preventing problems from opioid use during pregnancy
This study looks at ways to predict and reduce harmful outcomes for pregnant people with opioid use disorder (OUD) and their babies. It focuses on people who are already receiving ongoing medication treatment during pregnancy and will follow them around delivery at a specific hospital.
Pittsburgh, PennsylvaniaAges 18 years+
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Common questions
- Are there clinical trials for medications for opioid use disorder?
- Yes. Clin2 currently lists 226 recruiting medications for opioid use disorder studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a medications for opioid use disorder trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a medications for opioid use disorder trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.