Clinical trials
Medications for Opioid Use Disorder clinical trials
Below are recruiting medications for opioid use disorder clinical trials, each written for real people, not researchers. We’re tracking 223 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07214467Recruiting
Adaptive brain stimulation for opioid use disorder
This study tests a new type of brain stimulation that adapts to your brain activity, aiming to reduce cravings and help you control opioid use. It is for people with long-standing opioid use disorder who have not gotten lasting relief from at least 3 treatment attempts, including medication.
San Francisco, CaliforniaAges 22–75 - NCT07197801Recruiting
Peer support program for opioid use disorder treatment
This study tests if a peer recovery support program helps people stay in treatment for opioid use disorder. Participants who recently started medication for opioid use disorder may get extra support from a peer who has been through recovery themselves.
Danville, PennsylvaniaAges 18–89 - NCT07169409RecruitingPhase 1
Telehealth for opioid use disorder in vulnerable settings
This trial tests whether a telehealth program can help people with opioid use disorder get and stay on buprenorphine treatment. It aims to make care more accessible for those in vulnerable situations.
Portland, OregonAges 18 years+ - NCT07171359Recruiting
TMS therapy for opioid and alcohol use recovery
This trial tests whether TMS (a non-invasive brain stimulation) can improve recovery for people with both opioid and alcohol use disorders. You must be in a specific outpatient program in Portland, Oregon.
Portland, OregonAges 18 years+ - NCT07158853RecruitingPhase 1
Brain stimulation and training for opioid use disorder
This trial combines a gentle brain stimulation technique called tDCS with thinking exercises to see if it helps people with opioid use disorder who are already on medication. It aims to improve treatment outcomes
Minneapolis, MinnesotaAges 18 years+ - NCT07128524RecruitingPhase 2
Ketones for opioid craving study
This trial tests if a ketone supplement can help reduce cravings during opioid withdrawal treatment. Participants take the supplement daily and are monitored for changes in craving and withdrawal symptoms.
Wernersville, PennsylvaniaAges 18–75 - NCT07129902Recruiting
Reward program to support opioid medication after ER
This study tests if a reward-based program (called contingency management) helps people stick with their medication for opioid use disorder (like buprenorphine or methadone) after an emergency department visit.
Burlington, VermontAges 18 years+ - NCT07115030Recruiting
Support program for women with opioid use disorder and past abuse
This trial tests a stepped care program for women who have experienced intimate partner violence and are in treatment for opioid use disorder. It aims to improve recovery by addressing post-traumatic stress symptoms and overall well-being.
Bridgeport, ConnecticutAges 18 years+ - NCT07079215Recruiting
Device trial for opioid withdrawal symptoms
This trial tests a physical device (ADTPM 1) to help manage withdrawal symptoms in people who are dependent on opioids. The goal is to see if the device can safely reduce withdrawal discomfort.
Daegu, DaeguAges 19–80 - NCT07079826Recruiting
Sparrow Link device for opioid withdrawal in hospital
This trial tests a device placed on the ear to help manage opioid withdrawal symptoms in hospitalized adults. It's for people still having withdrawal despite standard medications or those who've chosen not to take methadone or buprenorphine.
Pittsburgh, PennsylvaniaAges 18 years+ - NCT07044466Recruiting
Social functioning study for people in treatment for opioid use
This study looks at how people recovering from opioid use disorder get along with a close friend or family member (called a CSO). It may help improve social support during early treatment.
Charleston, South CarolinaAges 18 years+ - NCT06999811Recruiting
Technology vs. medication monitoring for buprenorphine in pregnancy
This study compares two approaches to help pregnant people stay on buprenorphine (a medication for opioid use disorder): one uses technology to support therapy, and the other uses standard medication monitoring. It aims to see which method works better for keeping you in treatment during pregnancy.
Charleston, South CarolinaAges 18–45 - NCT06981195RecruitingPhase 2
Testing lemborexant for insomnia in people on buprenorphine
This study tests if the sleep medication lemborexant can help people with opioid use disorder who also have chronic insomnia. Participants must already be taking buprenorphine (Suboxone) for at least 4 weeks. The goal is to see if better sleep improves mood and reduces opioid use.
Richmond, VirginiaAges 18 years+ - NCT06943859RecruitingPhase 2
Ketamine for opioid use disorder
This study tests whether ketamine, when added to methadone treatment, helps reduce opioid use and cravings. It is for adults with opioid use disorder who are already in a methadone program and have had recent cravings or illicit use. The trial involves multiple visits and follow-up assessments.
Baltimore, MarylandAges 18–65 - NCT06949826RecruitingPhase 4
Buprenorphine for pain after ankle fracture surgery
This trial tests if buprenorphine, a non-opioid pain medicine, works well for people who have not used opioids before. After ankle fracture surgery, you would get buprenorphine instead of stronger opioids to see if it controls pain just as well with fewer side effects.
St Louis, MissouriAges 18 years+ - NCT06940674RecruitingPhase 3
CBD plus opioid treatment for recovery
This study tests whether adding cannabidiol (CBD) to your usual methadone or buprenorphine treatment helps you recover from opioid use disorder. If you're already in stable treatment with those medications, the trial aims to see if CBD can improve your outcomes.
New York, New YorkAges 18–65 - NCT06880718RecruitingPhase 4
Injectable buprenorphine for opioid use disorder in prison
This study tests whether a once-monthly injection of buprenorphine (called extended-release buprenorphine, or XR-B) works well for people in prison who are already in a medication program for opioid use disorder. It looks at preferences and outcomes in the last months before release.
Cranston, Rhode IslandAges 18 years+ - NCT06872190Recruiting
CDS tool for opioid use disorder in the ED
This trial tests a clinical decision support tool for emergency department providers at UCSF. It helps doctors give better care that considers social needs alongside opioid use treatment. The study will ask providers and patients about how well this tool works.
San Francisco, CaliforniaAges 18 years+ - NCT06857968Enrolling by invitation
Mobile mindfulness training for opioid use disorder treatment
This study tests if a mobile mindfulness training app can help people who are receiving medication treatment for opioid use disorder. It is for people with a history of childhood trauma who are stable on their medication.
Lexington, KentuckyAges 18–65 - NCT06837662Recruiting
Counseling and peer support for opioid use disorder in primary care
This study tests whether adding counseling and peer support helps people with opioid use disorder and other medical problems stay in treatment. It is for patients seen at Central City Concern in Portland who are starting or restarting medication for opioid use disorder, or who are not yet on medication but want help.
Portland, OregonAges 18 years+ - NCT06832007Recruiting
Light therapy for recovery from opioid use disorder
This study tests whether a special light device used at home can improve recovery in people being treated for opioid use disorder. It looks at how light might help with sleep, mood, and overall well-being.
Birmingham, AlabamaAges 18–60 - NCT06796062RecruitingPhase 2
Psilocybin for opioid use disorder
This study tests whether psilocybin can help people who want to stop using opioids and are already in treatment. Eligible participants receive a single dose of psilocybin in a supervised setting and are followed to see if it reduces opioid use.
Albuquerque, New MexicoAges 18–65 - NCT06800703Recruiting
Opioid use, pain, and the brain
This study uses brain scans (MRI) to understand how pain affects people with opioid use disorder or regular opioid use, compared to healthy volunteers. It aims to find better ways to treat both pain and opioid addiction.
New Haven, ConnecticutAges 21–60 - NCT06774248Recruiting
Teen opioid recovery support program with medication
This study tests a program called YORS that helps teens with opioid use disorder stick with their medication. It involves you and a support person (like a parent) working together with the study team to stay on track.
Baltimore, MarylandAges 13–21
Hear when a new Medications for Opioid Use Disorder trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.
Common questions
- Are there clinical trials for medications for opioid use disorder?
- Yes. Clin2 currently lists 223 recruiting medications for opioid use disorder studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a medications for opioid use disorder trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a medications for opioid use disorder trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.