Clinical trials
Melanoma clinical trials
A serious form of skin cancer that develops in pigment-producing cells. We’re tracking 458 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07407166Recruiting
Immunotherapy for first-line metastatic melanoma in Slovenia
This study follows people with melanoma that has spread to other organs who are receiving immunotherapy as their first treatment. Researchers want to see how well this therapy works and look for clues in the body that predict response.
LjubljanaAges 18 years+ - NCT06605417Recruiting
Understanding Birthmark to Melanoma Changes
This study looks at how certain birthmarks (nevi) change over time and might turn into melanoma. By studying tissue samples, researchers hope to better understand this process.
MarseilleAges Any age - NCT06605443Recruiting
Precision medicine for large/giant congenital nevus and melanoma
This trial uses a precision medicine approach for people with melanoma. It studies how volatile organic compounds (substances your body releases) might help guide treatment for stage II, III, or IV melanoma.
BarcelonaAges 18 years+ - NCT06608420Recruiting
Precision Medicine Study for Melanoma
This study looks at using precision medicine to better understand and treat melanoma. Patients with a confirmed melanoma diagnosis can join, helping doctors learn more about the disease and improve care.
Barcelona, CataloniaAges Any age - NCT05512481RecruitingPhase 2
Study combination treatment before surgery for high-risk acral melanoma
This Phase 2 trial tests three medicines given before surgery for people with high-risk acral melanoma (a skin cancer type). It aims to shrink or control the cancer earlier and see how well the treatment works and is tolerated.
Beijing, Beijing MunicipalityAges 18–75 - NCT06488365Recruiting
Melanoma blood test using a new device (Cytophone)
This trial tests a new, non-invasive device called a liquid biopsy that looks for melanoma cells in your blood. It may help find cancer earlier without needing a needle biopsy.
Madison, WisconsinAges 18–80 - NCT07251335Recruiting
Melanoma and work sun exposure study
This study looks at whether men and women who get melanoma (a type of skin cancer) have had more sun exposure at work compared to those who don't have melanoma. It aims to help find and prevent work-related skin cancers.
Modena, MoAges 18 years+ - NCT07237100RecruitingPhase 2
Mirdametinib for advanced NF1-mutant melanoma
This trial tests an experimental oral drug called mirdametinib for people with advanced melanoma that has a specific gene change (NF1 mutation). To join, you must have already had immunotherapy, but not a MEK/ERK/RAF targeted drug before.
San Francisco, CaliforniaAges 18 years+ - NCT07230613RecruitingPhase 2
Immunotherapy before surgery for localized melanoma
This trial tests if giving two immunotherapy drugs (nivolumab and ipilimumab) before surgery can improve outcomes for patients with stage III melanoma that can be removed. It is for people who have not had certain treatments recently or whose melanoma is not in the eye.
BordeauxAges 18 years+ - NCT07130032RecruitingPhase 2
Immunotherapy combo for advanced lung cancer or melanoma
This trial tests a combination of immunotherapy drugs (anti-PD-1/PD-L1 antibodies) plus bevacizumab and a low-dose chemotherapy called cyclophosphamide for people with advanced lung cancer or melanoma who have already been on immunotherapy and their cancer has progressed.
Saint Petersburg, Sankt-PeterburgAges 18 years+ - NCT07092670Recruiting
Melanoma treatment after surgery and its effect on fertility
This study looks at how adjuvant therapy (treatment after surgery) affects fertility in women under 40 who have had their melanoma completely removed. It will help doctors understand and manage the impact on future childbearing.
BariAges Up to 40 years - NCT05970497RecruitingPhase 1/Phase 2
KB707 trial for advanced solid tumors after other treatments
This early-stage trial tests KB707 in people with locally advanced or metastatic solid tumors that have not responded well to standard treatments. If you qualify, you may receive KB707 to see how well it can shrink tumors or control the disease.
Los Angeles, CaliforniaAges 18 years+ - NCT07063875RecruitingPhase 1/Phase 2
Adding IL-2 to tebentafusp for advanced eye cancer
This trial tests if adding another drug called IL-2 to tebentafusp can help stop cancer from growing in people with advanced melanoma that started in the eye (uveal melanoma). It is for those whose cancer got worse while on tebentafusp alone.
Sydney, New South WalesAges 18 years+ - NCT07057596RecruitingPhase 2
Tebentafusp before surgery for uveal melanoma in the liver
This trial tests a drug called tebentafusp before surgery for uveal melanoma that has spread to the liver. The goal is to see if giving the drug first can shrink the tumors and make surgery more effective.
Berlin, State of BerlinAges 18 years+ - NCT06999980RecruitingPhase 2
NEOadjuvant Ipi Nivo Rela for Melanoma
This trial tests a combination of three immunotherapy drugs (ipilimumab, relatlimab, and nivolumab) given before surgery to people with melanoma that can be completely removed. The goal is to see if this treatment shrinks the tumor and improves outcomes.
Wollstonecraft, New South WalesAges 18 years+ - NCT06889766RecruitingPhase 1
NY-ESO-1 T cells for advanced melanoma and sarcoma
This trial tests a personalized cell therapy using your own immune cells (T cells) that have been modified to recognize a protein called NY-ESO-1, which is found on some melanoma and sarcoma tumors. It may help people whose cancer has progressed after standard treatments.
Lausanne, Canton of VaudAges 18 years+ - NCT06767306RecruitingPhase 2
SBRT radiation plus immunotherapy for limited spread melanoma
This trial tests if combining targeted radiation (SBRT) with standard immunotherapy works better for melanoma that has spread to a few spots in the body (but not the brain). It is for people who have not yet had treatment for their current spread.
Westmead, New South WalesAges 18 years+ - NCT06673095Recruiting
Narrow vs wide surgery for invasive skin melanoma
This trial compares two surgeries for invasive melanoma: a narrow removal versus a wider one. It aims to see if a smaller surgery works as well, which could mean less scarring and recovery time.
Davis, CaliforniaAges 18 years+ - NCT06660420RecruitingPhase 1
PRAME-targeted NK cells for advanced melanoma
This trial tests a new type of cell therapy using your own immune cells (NK cells) modified to target a protein called PRAME found on melanoma cells. It is for people whose melanoma has not responded to or has returned after standard immunotherapies.
Houston, TexasAges 18 years+ - NCT06627244RecruitingPhase 2
Study of tebentafusp and radioembolization for uveal melanoma that spread to the liver
This trial tests whether combining a drug called tebentafusp with a procedure called radioembolization can help control uveal melanoma that has spread mainly to the liver. Radioembolization delivers tiny radioactive beads to the liver, and tebentafusp helps your immune system attack the cancer.
Miami, FloridaAges 18 years+ - NCT06298734Recruiting
Exercise and diet study for melanoma patients on immunotherapy
This study tests whether adding high-intensity exercise and a high-fiber diet can improve how well immunotherapy works for people with melanoma. It might help you if you are already on immunotherapy and are not currently very active or eating a lot of fiber.
Boston, MassachusettsAges 18 years+ - NCT06284590RecruitingPhase 2
Study of immune therapy injections for advanced melanoma
This trial tests whether injecting immune-boosting drugs directly into melanoma tumors, alongside the immunotherapy pembrolizumab, can help people whose cancer has not responded to previous immunotherapy. It aims to shrink tumors and improve treatment outcomes.
Hartford, ConnecticutAges 18 years+ - NCT01898039RecruitingPhase 1/Phase 2
Vaccine study for certain melanoma patients with specific blood markers
This trial tests a modified vaccine to help the immune system recognize melanoma. It is mainly for people with melanoma at higher risk or certain stages, and who have specific inherited tissue markers on blood testing.
JerusalemAges Any age - NCT06163820RecruitingPhase 1/Phase 2
Bevacizumab and immunotherapy with radiation for melanoma brain metastases
This trial tests a combination of a drug that stops blood vessel growth (bevacizumab), immunotherapy, and focused radiation to treat melanoma that has spread to the brain and is causing symptoms. The goal is to see if this approach shrinks tumors and improves outcomes.
Melbourne, VictoriaAges 18 years+
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Common questions
- Are there clinical trials for melanoma?
- Yes. Clin2 currently lists 458 recruiting melanoma studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a melanoma trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a melanoma trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.