Clinical trials
Mental Health clinical trials
Below are recruiting mental health clinical trials, each written for real people, not researchers. We’re tracking 701 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT04356274Enrolling by invitation
Improving access to addiction and mental health care at VA clinics
This study tests an approach to help VA clinics reach more Veterans with proven treatments for addiction and mental health conditions. It focuses on clinic-level processes (not individual medications) to increase how widely evidence-based care is delivered.
Palo Alto, CaliforniaAges 18 years+ - NCT04159662Recruiting
Brain scans to study thinking in schizophrenia and depression
This study uses brain imaging to better understand how thinking works in people with schizophrenia or major depression. Your results may help researchers learn what brain patterns match different thinking and symptoms.
Ottawa, OntarioAges 18–60 - NCT04106713Recruiting
Understanding change across different psychotherapies for anxiety and depression
This study looks at how people change during different types of psychotherapy for anxiety and depression. It aims to understand which treatments work best for different people.
Singapore, SingaporeAges 18–99 - NCT03973268RecruitingPhase 1
Ketamine study to understand treatment response in hard-to-treat depression
This early-stage study tests ketamine and looks at what brain changes may explain why it helps people with major depression that hasn’t improved with usual treatments. You may be asked to stay in the hospital and complete detailed interviews, mood rating scales, and brain imaging.
Bethesda, MarylandAges 18–70 - NCT03911726Recruiting
Brain imaging study of antipsychotic effects in schizophrenia
This study uses PET and MRI scans to see how antipsychotic medications affect the brain's dopamine system in people with schizophrenia, compared to healthy individuals. It may help understand if these medications cause changes that lead to worsening symptoms over time.
Mannheim, Baden-WurttembergAges 18–65 - NCT03906435Recruiting
Cognitive therapy to prevent problems for very premature NICU babies
This study offers a counseling approach to help prevent “Vulnerable Child Syndrome” in babies born very early and cared for in the NICU. It focuses on support during the early months after birth and compares outcomes for families getting the therapy versus usual support.
Dallas, TexasAges Any age - NCT03388606Recruiting
Studying adolescent depression and how to treat it
This study looks closely at how depression shows up in teens and tests approaches to treatment. It may help teens and families better understand depression and get access to structured care as part of research.
Los Angeles, CaliforniaAges 11–25 - NCT03304665Recruiting
Healthy volunteers needed for brain and behavior research studies
This study recruits healthy adults to help researchers run mental health and brain-related experiments. It may help future studies by improving how they measure brain function and behavior.
Bethesda, MarylandAges 18–70 - NCT03380078Enrolling by invitation
Training programs to better support kids with autism
This study tests an organized training plan meant to help mental health programs and schools support children with autism. It involves leaders, therapists/providers, and parents who complete brief surveys and assessments to see what improves care and services.
Sacramento, CaliforniaAges 18 years+ - NCT03065335RecruitingPhase 1
Ketamine plus brain imaging to study response in depression
This early-stage study tests how ketamine given once and then repeatedly may change brain signals and related biomarkers in people with major depression. If you’re eligible, the team will use brain imaging and assessments to see who responds and why.
Bethesda, MarylandAges 18–65 - NCT02543983RecruitingPhase 2
Brain scan and ketamine study for suicidal thoughts
This trial studies how ketamine affects the brain in people dealing with suicidal thoughts or an active suicide crisis. It uses questionnaires, consent testing, and brain imaging to look for biological changes that may relate to symptom improvement.
Bethesda, MarylandAges 18–70 - NCT02531893Recruiting
Therapy for youth with severe, frequent irritability
This study tests whether two structured therapies can reduce severe irritability and angry reactions in children and teens. It focuses on youth who have had long-lasting, frequent outbursts and trouble responding to negative emotions.
Bethesda, MarylandAges 8–17 - NCT02639702RecruitingPhase 4
Switching from twice-daily to once-daily clozapine for schizophrenia
This trial tests whether taking clozapine once a day (instead of twice a day) works safely for people with schizophrenia. It may help by simplifying your dosing schedule while closely monitoring your wellbeing.
Toronto, OntarioAges 18 years+ - NCT01617408Recruiting
Brain stimulation and vision testing in healthy adults
This study uses brain stimulation and brain imaging (MRI) along with vision tests to understand how the brain supports seeing. You might be eligible if you are a healthy adult and can safely complete MRI and stimulation tasks.
Bethesda, MarylandAges 18–50 - NCT01434368Recruiting
Understanding brain and hormone changes during puberty
This study follows children and young adults through puberty to understand how hormones and brain development change together using MRI scans and other tests. If you or your child are healthy and fall into one of the study's age ranges, this research could help explain how puberty affects the brain.
Bethesda, MarylandAges 7–35 - NCT01327690RecruitingEarly Phase 1
Group therapy for mental health in veterans and families
This early-stage study looks at mental health outcomes for active-duty service members, veterans, and their family members after participating in group therapy sessions. If you can follow instructions and complete consent forms, this trial may help researchers understand how group therapy affects well-being in these communities.
Santa Rosa, CaliforniaAges 18–80 - NCT01132885Recruiting
Brain scans in children with Williams syndrome
This study uses brain testing—often MRI scans—to learn how the brains of children with Williams syndrome are different from typical development. It may help researchers better describe brain patterns and improve future care for people with Williams syndrome.
Bethesda, MarylandAges 5–99 - NCT00397111Recruiting
MRI brain-scanning study of mood and anxiety in adults
This study uses brain MRI scans and mental tasks to better understand mood and anxiety problems. It may help researchers develop improved MRI methods for studying depression and healthy brain function.
Bethesda, MarylandAges 18–65 - NCT00024635Recruiting
Understanding Mood and Anxiety Disorders Study
This research study evaluates people with mood disorders (like depression or bipolar disorder), anxiety disorders, or people without these conditions to better understand how these conditions develop and affect the brain. Researchers will ask questions and may do other assessments to learn more.
Bethesda, MarylandAges 3–99 - NCT01087281Recruiting
Testing how brain “top-down” attention helps visual processing
This study looks at how signals from the brain’s thinking/attention systems affect how we process what we see. It may help researchers understand brain attention after stroke or other focal brain injuries, and compare with healthy volunteers.
Bethesda, MarylandAges 18–100 - NCT00025935Recruiting
Brain function study in children with mood problems
This study looks at how the brain works and how mood disorders change over time in children and teens with severe irritability, anger, and temper outbursts. It includes brain scans and regular check-ins to understand the illness better.
Bethesda, MarylandAges 7–85 - NCT00018057RecruitingPhase 2
Brain study of pediatric anxiety disorders
This study looks at how the brain works in children and adults with anxiety disorders. It uses brain scans (fMRI) and other safe tests to understand anxiety better.
Bethesda, MarylandAges 8–65 - NCT00271622Recruiting
Screening test for child or adult brain and behavior patterns
This study uses a structured check-up to learn about how someone’s thinking, behavior, and development may differ from typical patterns. It involves an interview and possibly medical, nervous-system, and blood or urine tests to understand what kinds of issues might be present.
Bethesda, MarylandAges 1 month+ - NCT00001360Recruiting
Studying brain blood flow during thinking
This study looks at how blood flow in the brain changes while you are thinking. You will do tasks while having brain scans to help researchers understand normal brain activity.
Bethesda, MarylandAges 18–65
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Common questions
- Are there clinical trials for mental health?
- Yes. Clin2 currently lists 701 recruiting mental health studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a mental health trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a mental health trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.