Clinical trials
Mesothelioma clinical trials
Below are recruiting mesothelioma clinical trials, each written for real people, not researchers. We’re tracking 91 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06057935RecruitingPhase 2
Extra chemotherapy after surgery for peritoneal mesothelioma
This trial tests whether more chemotherapy after surgery can help people with a specific type of abdominal cancer (malignant peritoneal mesothelioma). It is for those who have had all visible tumor removed and have not had chemotherapy before.
Chicago, IllinoisAges 18 years+ - NCT07126509Recruiting
Surgery for pleural mesothelioma that cannot be fully removed
This trial tests if a partial surgery called pleurectomy can help people with a specific type of mesothelioma that cannot be fully removed. You must have already completed at least 6 weeks of chemotherapy or immunotherapy without the cancer growing.
Chicago, IllinoisAges 18 years+ - NCT05188859RecruitingPhase 2
Testing sintilimab, anlotinib, and chemo for pleural mesothelioma
This Phase 2 study tests whether adding three medicines—sintilimab, anlotinib, and standard platinum chemo—can control malignant pleural mesothelioma that cannot be removed by surgery. It may help shrink tumors and slow disease progression, but you must meet specific health and prior-treatment requirements.
Taiyuan, ShanxiAges 18 years+ - NCT06477419RecruitingPhase 2
Sacituzumab govitecan for mesothelioma after prior treatment
This study tests a drug called sacituzumab govitecan (a targeted therapy that delivers chemotherapy directly to cancer cells) for people with mesothelioma that has already been treated with other therapies. The goal is to see if the drug can shrink tumors and help control the disease.
Basking Ridge, New JerseyAges 18 years+ - NCT06581549Recruiting
Immune and gene study in mesothelioma
This study is looking at the immune system and genes in mesothelioma tumors. It aims to learn more about how the body reacts to the cancer, which may help in finding better treatments in the future.
Rozzano, MilanoAges 18 years+ - NCT05647265RecruitingPhase 2
Immunotherapy before surgery for sarcomatoid pleural mesothelioma
This trial tests adding immunotherapy before surgery to help patients with sarcomatoid pleural mesothelioma. The goal is to shrink or control the cancer and make surgery possible, while checking safety.
Anchorage, AlaskaAges 18 years+ - NCT07277413RecruitingPhase 1
Study of IDE892 for advanced solid tumors with MTAP deletion
This study tests a new drug called IDE892, alone or in combination, for people with advanced solid tumors that have a specific genetic change (MTAP deletion). The goal is to see if the drug is safe and whether it can shrink tumors.
Santa Rosa, CaliforniaAges 18 years+ - NCT04981119Recruiting
Test apheresis for CAR T manufacturing in HLA-A2 solid tumors
This trial studies how a process called apheresis is used to make CAR T cells for people with certain solid tumors. It is designed for tumors that have lost a specific immune marker (HLA-A*02), which may affect how well CAR T therapies work.
Gilbert, ArizonaAges 18 years+ - NCT07121374RecruitingPhase 1/Phase 2
Chemotherapy and immunotherapy before possible surgery for mesothelioma
This trial tests whether giving chemotherapy and immunotherapy before planned surgery can make inoperable pleural mesothelioma operable. It is for people with a specific type of mesothelioma (epithelioid) that cannot be removed right away, to see if the treatment shrinks the tumor enough for surgery later.
Edegem, AntwerpAges 18 years+ - NCT03830229Recruiting
Long-term follow-up for people with BAP1 mutations
This study follows people with a harmful (deleterious) BAP1 gene change to learn how it affects health over time. It may help researchers better understand mesothelioma risk and the long-term outcomes for families with this genetic mutation.
Bethesda, MarylandAges 2–120 - NCT06885697RecruitingPhase 1
CAR T cells targeting mesothelin for solid tumors
This study tests a new treatment called CAR T cells that target a protein called mesothelin found on certain cancer cells. The CAR T cells are made from your own immune cells and may help shrink tumors that have not responded to other therapies.
Bethesda, MarylandAges 18–120 - NCT05001880RecruitingPhase 2
Chemo with or without immunotherapy for peritoneal mesothelioma
This study tests whether adding immunotherapy to standard chemotherapy helps people with peritoneal mesothelioma, a cancer in the lining of the abdomen. You may receive chemotherapy alone or with immunotherapy, and the goal is to improve cancer control.
Phoenix, ArizonaAges 18 years+ - NCT07234058RecruitingPhase 2
Testing new drug combinations for pleural mesothelioma
This trial tests adding a drug called fianlimab to another drug (cemiplimab) plus chemotherapy for people with a type of lung cancer called pleural mesothelioma. It aims to see if the combination is more effective than cemiplimab plus chemo alone.
Aix-en-ProvenceAges 18–75 - NCT06840834RecruitingPhase 2
New drug for mesothelioma that has returned after prior treatment
This trial tests a drug called ivonescimab for people with pleural mesothelioma (a cancer of the lung lining) that has grown back after earlier immunotherapy and chemotherapy. The drug may help by blocking a protein that tumors use to hide from the immune system, possibly slowing or shrinking the cancer.
BesançonAges 18 years+ - NCT07330271Recruiting
Personalized drug testing for peritoneal mesothelioma treatment
This trial uses a test on your tumor tissue to find which chemotherapy drugs work best for you, after standard surgery and heated chemotherapy. It aims to make your treatment more effective by choosing drugs that match your cancer.
BeijingAges 18–85 - NCT06875076RecruitingPhase 2
Ivonescimab plus chemotherapy for pretreated mesothelioma
This trial is testing a new immunotherapy drug (ivonescimab) combined with chemotherapy for people with mesothelioma that has already been treated. It aims to see if this combination can shrink tumors or slow the disease.
Changchun, JilinAges 1.5 years–6.3 years - NCT03683680Recruiting
Collecting pleural tissue samples to study mesothelioma markers
This study collects tissue samples (from the lining around the lung) from adults with malignant pleural mesothelioma. Researchers will use these samples to check whether certain test markers can predict how the disease may behave, which could guide treatment decisions in the future.
Boston, MassachusettsAges 18 years+ - NCT03760575RecruitingPhase 1
Pembrolizumab plus chemo with surgery for pleural mesothelioma
This trial studies how well pembrolizumab (an immune therapy) works when added to chemotherapy before image-guided surgery for malignant pleural mesothelioma. It aims to shrink or control the cancer and improve surgical results by combining treatments.
Philadelphia, PennsylvaniaAges 18 years+ - NCT04400539RecruitingPhase 2
Nivolumab plus 5-ALA light treatment for pleural mesothelioma
This Phase 2 study tests whether adding nivolumab (an immunotherapy) to a one-time “light-based” treatment during a lung procedure can control malignant pleural mesothelioma that can’t be surgically removed. You may be eligible if your cancer has come back or progressed after prior platinum chemotherapy, and if your tumor is reachable for the light treatment during thoracoscopy.
LilleAges 18 years+ - NCT04431024Recruiting
Testing imaging and biopsy options for people with BAP1 risk
This study looks at how well advanced scans, liquid biopsy tests, and small follow-up procedures can find early mesothelioma in people with a high-risk BAP1 gene condition. It may help catch cancer earlier when treatment could work better.
Bethesda, MarylandAges 30–120 - NCT04515836RecruitingPhase 2
Olaparib for HRD malignant mesothelioma after platinum chemotherapy
This trial tests whether olaparib (a cancer medicine) can help control malignant mesothelioma that has specific DNA changes. You must have already had platinum chemotherapy and your cancer must be “platinum-sensitive,” plus your tumor (or family/genetic cells) must show certain gene problems.
Chicago, IllinoisAges 18 years+ - NCT04847063RecruitingPhase 1
Test drug heating inside the abdomen for peritoneal cancer
This Phase 1 trial tests a treatment that delivers heated chemotherapy directly into the abdomen (HIPEC) for certain cancers that have spread only within the abdominal lining. It aims to see how safely and effectively this approach works, especially when doctors can remove as much tumor as possible.
Bethesda, MarylandAges 18–120 - NCT04996017RecruitingPhase 3
Atezolizumab after surgery for malignant pleural mesothelioma
This study tests whether atezolizumab given after surgery and chemotherapy can lower the risk of mesothelioma coming back compared with a placebo. It may help by boosting the immune system to control remaining microscopic cancer cells.
Meldola, ITAòYAges 18 years+ - NCT05304208RecruitingPhase 1
Mesothelioma trial using immune cells plus surgery
This early-phase study tests a treatment that uses a patient’s immune cells (dendritic cell therapy) combined with surgery for epithelioid mesothelioma. It aims to help the immune system better recognize and attack the cancer after chemotherapy and before/around surgery.
Rotterdam, South HollandAges 18 years+
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Mesothelioma trials by city
Studies with a site in or near these metro areas.
Mesothelioma trials by state
Studies with a site anywhere in these states.
Common questions
- Are there clinical trials for mesothelioma?
- Yes. Clin2 currently lists 91 recruiting mesothelioma studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a mesothelioma trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a mesothelioma trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.