Metabolic Disease clinical trials

Liver metabolism study in non-alcoholic fatty liver disease

This trial studies how the liver processes fat in people with non-alcoholic fatty liver disease (NAFLD). It uses MRI scans to look at liver metabolism, which may help doctors understand the disease better and find new treatments.

How bariatric surgery changes liver metabolism in fatty liver disease

This study looks at how bariatric (weight-loss) surgery affects how your liver processes nutrients in people with non-alcoholic fatty liver disease. It may help researchers understand what changes in the body after surgery and whether that could guide better future care.

Biopsy-based study for alcohol and metabolic liver disease

This trial studies people with liver disease linked to alcohol use or metabolic syndrome (a cluster of conditions like weight gain and insulin resistance). It uses recent standard-of-care liver biopsy results to better understand these chronic liver problems and how they relate to cancer risk.

Cardiometabolic risk registry for adults

This study is a health registry that collects information about risk factors for heart and metabolic problems in adults. It may help doctors better understand who is at higher risk and guide future prevention strategies.

Personalized diet testing using ZOE app and blood samples

This trial studies how different food compositions affect your body, using the ZOE testing program plus meals you eat and blood samples you collect. It may help you learn more about what foods work best for you, especially if you have a long-term health condition.

Study of metabolism and plaque changes in heart disease

This trial looks at how treating or managing conditions like diabetes, prediabetes, obesity, kidney disease, or high cholesterol affects artery plaque over time. It may help researchers find ways to slow plaque buildup and related heart risks.

Brain scan study of amyloid and brain sugar use

This study uses brain imaging to measure two things in the brain—amyloid protein and how the brain uses sugar. It may help researchers better understand early brain changes in people in the ALFA project.

Oxygen-based blood flow management after heart surgery

This study is testing a new way to manage blood flow after heart surgery in children with congenital heart disease. The goal is to make sure the body gets the right amount of oxygen to help recovery.

Blood and urine tests to study heart risk in kidney disease

This study looks for new markers in blood or urine that may help explain heart (cardiovascular) risk in people with chronic kidney disease. It may help doctors better predict risk, especially in those not yet on dialysis.

Saliva test for gum disease in pregnancy

This study looks at how pregnancy and gum disease might change the chemicals in your saliva. By comparing pregnant women and non-pregnant women, researchers hope to find a simple way to screen for gum problems during pregnancy.

Lifestyle medicine for rural patients with chronic disease

This trial tests whether exercise therapy can help people with two or more chronic conditions like obesity, diabetes, or heart disease. It's designed for rural patients and requires a referral from your doctor.

Heart and metabolic scan study of weight and rehabilitation

This study uses detailed heart scans and information about metabolism (how your body uses energy) to understand how metabolic treatments and heart rehabilitation may affect your health. You may qualify either as someone undergoing bariatric (weight-loss) care or as part of a heart rehabilitation group—or as a healthy comparison group.

Time-restricted eating for metabolic health

This study tests whether eating only during a specific time window each day can improve metabolic health in people with obesity and insulin resistance. If you have a high BMI and early signs of diabetes, this trial might help you understand a simple dietary change.

How PDE3B affects metabolism in healthy adults

This study looks at how a protein called PDE3B affects your body's metabolism (how it uses energy). It may help researchers understand weight and insulin resistance better, which could lead to new treatments.

Step counting for fatty liver disease management

This trial tests if using a pedometer to track daily steps can help people with a type of fatty liver disease (called MASLD) become more active and improve their health. It may be a good fit if you are not already very active and want to try a simple way to manage your condition.

Study how immune-related conditions affect metabolism

This study collects blood and other samples to see how the immune system changes “metabolism” (how your body uses energy) in people with immune-related conditions. Your samples may also be stored for future research and could help researchers better understand immune health.

Study drug for mitochondrial depletion disorder due to gene changes

This Phase 2 trial tests a treatment made from deoxynucleosides to help people with mitochondrial depletion disorder caused by certain gene changes. If you match the genetic diagnosis, the study may see whether the treatment improves symptoms or disease markers.

Study how aging and health affect body function and metabolism

This trial studies how the body changes with aging in both healthy people and people with health conditions. It may help researchers better understand what affects physical function and metabolism over time.

Nutrition study for metabolic syndrome

This study tests whether a personalized nutrition plan can improve health and lower the risk of chronic diseases like diabetes and heart disease in middle-aged adults with metabolic syndrome.

Biobank study of genetic and metabolic data in brain blood vessel disease

This study collects genetic and other health information from people with brain blood vessel (cerebrovascular) problems. It aims to help researchers understand causes and patterns that could lead to better care in the future.

MRI study of heart and brain reserve in children

This study uses MRI scans to compare how the body’s blood-flow “reserves” work in children with sickle cell anemia versus healthy children. It may help doctors understand why some children are at higher risk for blood vessel problems.

Assessment of the Impact of Repeated Ischemic Preconditioning Episodes on Hemodynamic and Metabolic Parameters in Patients at Various Stages of Chronic Kidney Disease

Fat Cell Function in Obesity and Metabolism Study

This study looks at how a type of immune cell (macrophage) in fat tissue processes lipids, and how that affects metabolism in people with different body weights. It may help us understand why some people with obesity develop diabetes and fatty liver while others do not.

Study of a new drug for cirrhosis from fatty liver disease

This trial tests a new medication (efimosfermin alfa) for people with cirrhosis (liver scarring) caused by MASH, a type of fatty liver disease. It aims to see if the drug can help improve liver health.