Clinical trials
Metabolic Disease clinical trials
Below are recruiting metabolic disease clinical trials, each written for real people, not researchers. We’re tracking 365 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07683065Recruiting
Secukinumab treatment in psoriasis patients with liver condition
This study looks at how well secukinumab works for psoriasis patients who also have a type of fatty liver disease called MASLD. It may help doctors understand if this treatment is a good option for people with both conditions.
Badalona, BarcelonaAges 18–100 - NCT07091539Recruiting
Fruit and vegetable vouchers for kids with fatty liver disease
This trial tests whether providing fruit and vegetable vouchers can help children with fatty liver disease (MASLD) improve their liver health. Families living in California with a child who has elevated BMI and liver enzymes may be eligible.
San Francisco, CaliforniaAges 6–17 - NCT07381257RecruitingEarly Phase 1
Rifaximin for fatty liver disease
This trial tests if rifaximin, a gut medication, can help reduce liver fat in people with metabolic fatty liver disease. It may be an option if you have at least one metabolic risk factor and a certain amount of liver fat.
ShanghaiAges 18–75 - NCT07488975RecruitingPhase 1
Microbial therapy for MASLD trial
This trial tests a new microbial therapy for MASLD, a type of fatty liver disease. It aims to improve liver health by targeting gut microbes.
TaipeiAges 18–70 - NCT07592013Enrolling by invitation
Ancestry Supplements for Fatty Liver Disease
This study tests whether a special supplement (made from cacao, nopal, and crickets) can help improve fatty liver disease in people with excess body fat. Fatty liver disease happens when fat builds up in the liver, and this trial investigates whether these natural ingredients can reduce that buildup.
Guadalajara, GuadalajaraAges 18–60 - NCT06768216Recruiting
Mediterranean vs. low-fat diet for fatty liver in overweight kids
This trial compares two diets—a Mediterranean-style diet and a low-fat diet—to see which better reduces liver fat in overweight children and teens with fatty liver disease (MASLD). It aims to find a safe, effective eating plan for young people.
New Delhi, National Capital Territory of DelhiAges 8–18 - NCT06632457RecruitingPhase 3
Survodutide for NASH/MASH cirrhosis: a phase 3 trial
This study tests an investigational drug called survodutide for people with a type of fatty liver disease (NASH or MASH) that has progressed to cirrhosis. The goal is to see if it can improve liver health.
Peoria, ArizonaAges 18 years+ - NCT06703450Enrolling by invitation
Liver fibrosis study with MRI for MASLD patients
This study is testing whether an MRI can help doctors see liver scarring (fibrosis) in people with MASLD, a type of fatty liver disease. It is for patients who already need a liver biopsy as part of their care, to compare the MRI results with the biopsy.
New York, New YorkAges 18–89 - NCT07530809Recruiting
Time-Restricted Eating for Fatty Liver Disease
This study tests whether eating within a limited time window each day can improve fatty liver disease (a buildup of fat in the liver). If you have moderate-to-advanced fatty liver disease and are overweight, this trial might help you learn if changing when you eat—rather than what you eat—can reduce liver fat and improve your health.
Homburg, SaarlandAges 18–75 - NCT06318169RecruitingPhase 3
Testing pegozafermin for MASH and liver fibrosis
This trial tests an experimental drug called pegozafermin to see if it can help people with MASH (a fatty liver disease) and liver scarring (fibrosis). It's for people who have moderate-to-advanced scarring but not cirrhosis, and who have not had other serious liver conditions or poorly controlled diabetes.
Birmingham, AlabamaAges 18–80 - NCT03372733RecruitingPhase 2
Omega-7 oil effects on blood fats and fullness
This study tests whether an omega-7 (palmitoleic acid–rich) oil changes your blood fat levels and how full you feel. It includes healthy adults and may help explain nutrition-based ways to support heart health.
Bethesda, MarylandAges 18–99 - NCT05000996Recruiting
Gut microbiome study for people having metabolic surgery
This study looks at your gut bacteria (your “microbiome”) around the time of metabolic surgery. It may help researchers understand how surgery affects gut health and related conditions like diabetes, blood pressure, and cholesterol.
Nashville, TennesseeAges 21–65 - NCT05005793RecruitingPhase 4
Alkali treatment to improve kidney graft blood vessel function
This trial tests whether adding an “alkali” treatment (to raise low blood bicarbonate) can improve blood vessel and kidney graft function in people whose kidney transplant is about 1 year old. It may help if you have lower-than-normal bicarbonate levels while on stable transplant and blood pressure medicines.
Aurora, ColoradoAges 18–80 - NCT05974904Recruiting
Study links a liver-related cell marker to fatty liver damage
This study looks at existing health survey data to see whether a specific immune-cell marker (called HsCAR) is related to fatty liver disease and liver scarring. It may help researchers better understand which people are at higher risk for worsening liver damage.
Chongqing, Chongqing MunicipalityAges 18–90 - NCT06359444Recruiting
Exercise therapy for fatty liver disease
This study tests whether a high-intensity exercise program can improve liver function and insulin sensitivity in people with MASLD (a type of fatty liver disease). It may help you if you are looking for a non-drug way to manage your condition.
GhentAges 18–75 - NCT06412536Recruiting
Heart, weight, and hormone trial screening survey
This trial is a quick survey to find out if you may be eligible for future studies on heart health, weight, or hormone-related conditions. It helps researchers match you with the right treatment options.
Brooklyn, New YorkAges 18 years+ - NCT06495333Recruiting
Gene and gut bacteria in Hispanic fatty liver patients
This study looks at how a gene variant (PNPLA3) relates to gut bacteria in Hispanic patients with fatty liver disease (MASLD) in Puerto Rico. It aims to understand the connection between your genes, your gut health, and your liver condition.
San JuanAges 21–75 - NCT06984510Recruiting
Early aging and diabetes risk with fatty liver
This study looks at how early biological aging might increase the chance of developing type 2 diabetes in people with a fatty liver (a condition called MASLD). It uses routine health check-up data to understand the link.
Ningbo, ZhejiangAges 20–90 - NCT07143968RecruitingPhase 2
Resmetirom for people with MASLD and HIV
This study tests if resmetirom can help people who have both HIV and a liver condition called MASLD (fat buildup in the liver not caused by alcohol). You may qualify if your liver has a certain amount of fat and stiffness, and your HIV is well controlled with stable medication.
Birmingham, AlabamaAges 18 years+ - NCT07159386Recruiting
Detecting advanced liver scarring in fatty liver disease
This study tests a new screening tool to find advanced liver scarring in people with liver disease linked to diabetes. It helps doctors decide who needs more tests or specialist care.
Charleston, South CarolinaAges 18 years+ - NCT06843148Recruiting
Does niacin help move fat from liver to fat tissue?
This study tests if niacin (a B vitamin) can help the body store fat safely in fat tissue instead of letting it build up in the liver. It may be an option for people with fatty liver linked to belly fat, without serious liver damage or other health issues.
Sherbrooke, QuebecAges 20–80 - NCT07378072Recruiting
12-week daytime eating study for fatty liver in obesity
This study tests if restricting eating to daytime hours for 12 weeks can reduce liver fat in people with obesity. It aims to help those with fatty liver disease improve their health without medication.
AngersAges 18–65 - NCT07527910RecruitingPhase 2
Study of ALN-PNP with or without tirzepatide for fatty liver disease
This trial tests a new drug, ALN-PNP, alone or with tirzepatide in people with a specific genetic type of fatty liver disease. It aims to see if the combination reduces liver fat.
Coronado, CaliforniaAges 18–75 - NCT06826807Enrolling by invitation
Lifestyle change study for fatty liver disease
This study tests whether adding a liver stiffness measurement to a lifestyle program helps people with MASLD (a type of fatty liver disease) improve their liver health. It is designed for people who have fatty liver and at least one sign of metabolic syndrome, like high blood pressure or diabetes.
Bangkoknoi, BangkokAges 18–80
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Common questions
- Are there clinical trials for metabolic disease?
- Yes. Clin2 currently lists 365 recruiting metabolic disease studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a metabolic disease trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a metabolic disease trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.