Clinical trials
Migraine Headache, With or Without Aura clinical trials
Below are recruiting migraine headache, with or without aura clinical trials, each written for real people, not researchers. We’re tracking 188 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07349004Recruiting
Migraine with aura and PFO study
This study looks at the link between migraine with aura and a small hole in the heart called PFO. It may help researchers understand what causes migraines in some people.
Bologna, BOAges 18 years+ - NCT07295587Enrolling by invitation
Headache impact study for Libbs employees
This trial looks at how headaches affect employees at Libbs Pharmaceutical. It uses health data from the Dr. Cefaleia app to understand the burden of headaches at work.
São Paulo, São PauloAges Any age - NCT07779486Recruiting
Intravenous magnesium for acute headache pain relief
This study compares two doses of intravenous (IV) magnesium to see which is more effective at relieving acute headache pain in the emergency department. It aims to provide a fast and effective treatment option for migraine, tension-type, or cluster headaches.
MonastirAges 18 years+ - NCT07652034Recruiting
Tracking migraine relief after a minimally invasive artery procedure
This study follows adults who undergo a procedure called middle meningeal artery embolization—a minimally invasive treatment that blocks blood flow to a specific artery thought to trigger migraines. The trial simply tracks your symptoms and quality of life before and after the procedure to understand how well it works.
Tacoma, WashingtonAges 18–64 - NCT07514208Enrolling by invitation
Headache Sensitivity and Pain Testing Study
This study examines how sensitive the skin and tissues around the head are in people with migraines or tension headaches. Researchers will perform gentle touch and pressure tests to understand pain patterns, which may help improve headache treatment in the future.
Barcelona, BarcelonaAges 18 years+ - NCT07223008Recruiting
Bilateral artery embolization for chronic migraine
This trial tests a procedure called bilateral middle meningeal artery embolization to see if it reduces chronic migraine symptoms in people who haven't found relief from other treatments. It's for those with frequent, disabling migraines that affect both sides of the head.
Baltimore, MarylandAges 18–80 - NCT07159750Recruiting
Study on new migraine drugs in real life
This study tracks how well new migraine medications (like Aimovig, Emgality, Ajovy, Vyepti, Qulipta, and Nurtec) work in everyday use. It may help you and your doctor understand if these treatments are a good option for your migraines.
Miami, FloridaAges 18 years+ - NCT07015411Recruiting
Neuro supplements for migraine prevention
This trial tests whether a combination of vitamins and supplements can help prevent migraines. It's for adults who have migraines often (at least 6 days per month) and want to try a non-drug option.
MechelenAges 18–75 - NCT06859463Enrolling by invitation
Muscle function and tenderness in headache patients
This study looks at how your neck and shoulder muscles work and feel tender if you have frequent headaches (at least 10 days per month). The researchers want to see if there are differences in muscle function and tenderness between people with migraine, tension-type headache, or posttraumatic headache.
Copenhagen, Region HAges 18–65 - NCT05780450Recruiting
Brain stimulation for long covid headaches and pain
This trial tests a safe, non-invasive brain stimulation technique (transcranial direct current stimulation, or tDCS) to see if it can reduce persistent headaches and chronic pain in people with long covid. If you have ongoing pain after a confirmed covid infection, this could offer a new way to find relief.
Paiporta, ValenciaAges 16 years+ - NCT06684249Recruiting
Comparing nerve block and Botox for chronic migraine
This study compares two treatments for chronic migraine: a nerve block (injection near the nerves in the head) and Botox injections. It aims to see which one works better to reduce headache days and improve quality of life.
Zagazig, Sharqia ProvinceAges 18–65 - NCT07103694Recruiting
Migraine drug database study
This study is building a database to learn more about migraine drugs. It may help researchers find better treatments for people with episodic or chronic migraine.
Milan, ItalyAges 18 years+ - NCT07040813RecruitingPhase 3
Two migraine medicines together for chronic migraine
This trial tests whether using both a CGRP antibody and Botox together works better than the CGRP antibody alone for chronic migraine. It may help if you have not tried these treatments before.
GrålumAges 18–70 - NCT06398353Recruiting
Acupuncture for frequent primary headaches
This study tests whether acupuncture can improve quality of life for people with frequent primary headaches (like migraines or tension headaches). If you have headaches more than twice a week, this trial may help you find relief.
Taoyuan, Select A StateAges 18 years+ - NCT06652724Recruiting
Psychological help for chronic pain in fibromyalgia and migraine
This study looks at how psychological factors and treatments might help with chronic pain in people with fibromyalgia and/or chronic migraine. It compares different groups to understand what works best.
Rome, RMAges 18–50 - NCT07629635RecruitingPhase 3
Closing a heart hole to treat migraines
This trial tests whether closing a small hole in the heart (called a PFO) can help eliminate migraines. If you have frequent migraines and no other major health issues, this procedure might reduce or stop your headaches.
New York, New YorkAges 18–55 - NCT07617441Recruiting
Brain and Psychology Study of Hard-to-Treat Migraines
This research study compares brain structure and psychological traits in people with chronic migraines that don't respond well to standard treatments versus healthy volunteers without migraines. Understanding these differences may help doctors develop better treatment options for difficult-to-treat migraines.
Catanzaro, CatanzaroAges 18–75 - NCT07500558Recruiting
Ultrasound-guided nerve block for chronic migraine pain relief
This study tests two power levels of a pulsed radiofrequency treatment aimed at a nerve cluster behind your cheekbone to reduce chronic migraine pain. If you have frequent migraines that haven't responded well to two or more preventive medications, this could be an option for you.
MinyaAges 20–70 - NCT07476053Recruiting
How light exposure affects migraine and sleep
This study looks at how office lighting and sleep quality affect migraine. You'll track your headaches and light exposure. The goal is to find ways to improve sleep and reduce migraine attacks.
Tempe, ArizonaAges 18 years+ - NCT07454798Recruiting
Virtual reality neurofeedback for teens with migraine
This study tests whether using virtual reality neurofeedback can help teens with migraine. You would wear a VR headset and learn to control your brain's activity to reduce headache frequency.
Kansas City, MissouriAges 10–16 - NCT07451769Recruiting
Testing a new drug target for migraine relief
This trial tests a substance that activates adrenomedullin receptors, which may be a new way to treat migraines. It may help people who have migraines without aura and aren't on preventive migraine medications.
Glostrup MunicipalityAges 18–65 - NCT07373275Enrolling by invitation
Lifestyle Medicine for Teen Migraine
This study tests whether a lifestyle medicine program (like healthy habits and stress management) can help reduce migraine headaches in teenagers. It's for teens who get frequent migraines and are patients at certain MaineHealth clinics.
Scarborough, MaineAges 14–18 - NCT07361549RecruitingPhase 2
Lidocaine injection for chronic migraine pain
This study tests if injecting lidocaine (a numbing medicine) into an artery in the head can reduce chronic migraine pain. It may help people who have frequent migraines and are already getting a brain imaging test.
Camden, New JerseyAges 18 years+ - NCT07347067Recruiting
Trigger point injections for chronic migraine
This study tests if injecting medication into specific painful spots in your muscles (called trigger points) can help reduce chronic migraine pain. It may be an option if you've tried other treatments but still have significant pain.
Beijing, Beijing MunicipalityAges 18–65
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Common questions
- Are there clinical trials for migraine headache, with or without aura?
- Yes. Clin2 currently lists 188 recruiting migraine headache, with or without aura studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a migraine headache, with or without aura trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a migraine headache, with or without aura trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.