Clinical trials
Migraine clinical trials
A neurological condition causing recurring, often disabling headaches. We’re tracking 200 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07754266Recruiting
Headache, ear, and dizziness registry
This study collects information from people who have headaches, ear problems, dizziness, or sinus issues to better understand these symptoms and how they relate to migraine. Your participation may help improve future treatments and diagnosis.
North Kingstown, Rhode IslandAges 18 years+ - NCT04628429Recruiting
Study CGRP blocker effects on migraine and body nerve function
This study tests a CGRP-blocking antibody to see how it affects migraine symptoms and the body’s automatic (involuntary) nerve functions. It may help people with migraine who have already tried several preventive medicines.
ViennaAges 18–64 - NCT06625060RecruitingPhase 2
Study of IPN10200 for preventing migraine in adults
This trial tests a new medicine called IPN10200 to see if it can prevent episodic or chronic migraine. It is for adults who have had migraine for at least a year and have tried at least one preventive treatment before.
Birmingham, AlabamaAges 18–80 - NCT07297901Enrolling by invitation
Breathing app study for migraine relief
This trial tests a smartphone-based breathing program to help reduce migraines. It uses heart rate data to guide breathing exercises tailored to you.
Phoenix, ArizonaAges 18 years+ - NCT04063540RecruitingPhase 2
Amiloride to prevent migraine aura episodes
This study tests whether amiloride can reduce how often migraine aura happens. It’s a proof-of-concept early study, meaning the main goal is to see if the approach seems to work and is safe for people with frequent aura.
BronAges 18–80 - NCT05484349RecruitingPhase 3
Tizanidine to prevent frequent migraine attacks
This Phase 3 trial tests tizanidine to help prevent migraine attacks. If you have frequent migraine with or without aura, it compares tizanidine against placebo while tracking your headaches in diaries.
Luzhou, SichuanAges 18–65 - NCT05654012Recruiting
Study of migraine risk in teens and kids
This study looks at how migraine may start or affect children by comparing young people who either have migraine symptoms or are at higher risk. It may help researchers understand migraine patterns and who could benefit from early prevention.
St Louis, MissouriAges 10–13 - NCT05334927Recruiting
Headache disorder registry for teens and adults with primary headaches
This study is a headache disorder registry that enrolls people with common, “primary” headache types such as migraine or tension headache, including some with medication-overuse headaches. It collects information to better understand these conditions and who they affect.
Anqing, AnhuiAges 12 years+ - NCT06507150Recruiting
AI-assisted migraine education for newly diagnosed patients
This study tests a new AI-powered learning tool to help people who were just diagnosed with migraine understand their condition better. You'll use the tool on your own device, and researchers will see if it's helpful and easy to use.
LuganoAges 18–65 - NCT06684249Recruiting
Comparing nerve block and Botox for chronic migraine
This study compares two treatments for chronic migraine: a nerve block (injection near the nerves in the head) and Botox injections. It aims to see which one works better to reduce headache days and improve quality of life.
Zagazig, Sharqia ProvinceAges 18–65 - NCT06882122Recruiting
Atogepant for episodic migraine: brain and body effects
This study tests a daily pill called atogepant to see how it affects the brain and body in people with episodic migraine. It may help if you have 8 to 14 migraine days a month and haven't tried CGRP treatments before.
Pavia, PAVIAAges 18–70 - NCT06893874Recruiting
Comparing migraine preventives chosen by a computer
This trial tests whether a computer algorithm can help pick the best migraine prevention medicine for you. You'll try one of several common preventives and track your headaches.
TrondheimAges 18–99 - NCT07021859Recruiting
Migraine with aura study using CGRP to trigger attacks
This study tests whether a substance called CGRP (a protein linked to migraines) can safely trigger a migraine with aura in people who already have this condition. You'll receive an infusion and be monitored to see how your body responds.
Glostrup MunicipalityAges 18–65 - NCT07040813RecruitingPhase 3
Two migraine medicines together for chronic migraine
This trial tests whether using both a CGRP antibody and Botox together works better than the CGRP antibody alone for chronic migraine. It may help if you have not tried these treatments before.
GrålumAges 18–70 - NCT07103694Recruiting
Migraine drug database study
This study is building a database to learn more about migraine drugs. It may help researchers find better treatments for people with episodic or chronic migraine.
Milan, ItalyAges 18 years+ - NCT07233941Recruiting
Cognitive and psychological study in migraine patients
This study looks at thinking abilities and psychological factors in people with migraines. It aims to understand how migraine affects memory, attention, and emotions.
MilanAges 18–65 - NCT07301008RecruitingPhase 4
Rimegepant to prevent predictable trigger-induced migraines
This trial tests whether a medication called rimegepant can prevent migraines when you take it before a known trigger (like exercise or stress). It is for people who get migraines often and can predict when one might happen.
McLean, VirginiaAges 18 years+ - NCT07419607Recruiting
Group therapy with exercise for teens with migraine
This study tests a group therapy program for teens with migraine. The program combines physical activity, muscle relaxation, and education about migraines. It aims to help teens manage their headaches better.
Innsbruck, TyrolAges 13–17 - NCT07567300Recruiting
Understanding Pain Patterns in Migraine and Neck or Back Pain
This study explores how migraine headaches, neck pain, and lower back pain may share similar pain mechanisms in the body. Researchers will ask you questions to understand your pain patterns and help identify connections between these conditions.
Gaziantep, MerkezAges 18–65 - NCT07573488Recruiting
Sleep, Stress, and Migraine: Observation and Training Study
This study explores how sleep and stress affect migraine headaches and tests whether improving sleep habits can help reduce migraines. You'll be observed and taught strategies over several months while researchers track your headaches and sleep patterns.
ZurichAges 18–65 - NCT06212661Enrolling by invitation
Study on migraine drugs and bladder symptoms
This study looks at how certain migraine treatments affect bladder symptoms like frequent or urgent urination. If you have hard-to-treat migraines and are starting a CGRP inhibitor or Botox injections, you may be able to join.
Cleveland, OhioAges 18 years+ - NCT07645924RecruitingPhase 3
Elismetrep for fast relief of migraine attacks
This trial tests a new oral medication called elismetrep (K-304) for quickly stopping migraine pain and other symptoms. If you have regular migraines, this could offer a new option that works fast when a migraine starts.
Birmingham, AlabamaAges 18–75 - NCT07018700RecruitingPhase 3
Study on Xeomin shots to prevent migraines
This trial tests if Xeomin injections can help prevent episodic migraines in people who have 6 to 14 migraine days per month. It's for those under 50 when their migraines started and who can tell migraine from other headaches.
Chandler, ArizonaAges 18 years+ - NCT07018713RecruitingPhase 3
Testing Xeomin injections to prevent chronic migraine
This trial tests if Xeomin (a botulinum toxin injection) can help prevent chronic migraine. If you have frequent migraine headaches, you may be able to join.
Chandler, ArizonaAges 18 years+
Hear when a new Migraine trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.
Common questions
- Are there clinical trials for migraine?
- Yes. Clin2 currently lists 200 recruiting migraine studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a migraine trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a migraine trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.